DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gli and Ces2e

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001093947.1	Gene:	Ces2e / 192257	RGDID:	621563	Length:	557	Species:	Rattus norvegicus

Alignment Length:	645	Identity:	177/645 - (27%)
Similarity:	273/645 - (42%)	Gaps:	136/645 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LAGWRE-----------DLQGKQRRDSLTLERDVFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHS 166
            |.||..           .:||   :||.:..|:    |:.|||:|..|::   .|.||   ..|:
  Rat     6 LPGWLNAVVWGLLLLFCQVQG---QDSASPIRN----THTGQVRGSFVHV---KDTKS---GVHT 57

  Fly   167 TVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGWQLLQAVDFGPA-CPQPVRYTG-------A 223
                       |||||:|.||....||.||.....|..::.....|| |.|.:....       .
  Rat    58 -----------FLGIPFAKPPIGPLRFAPPEPPEPWSGVRDGTSHPAMCLQNIDGLNLENLKIKM 111

  Fly   224 TKGIMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLN 288
            ::..:.|.||||||::|:| .........||||:||||....|.::.:.|.:||:..||||||:.
  Rat   112 SRSPVSMSEDCLYLSIYTP-AHTHKDSNLPVMVWIHGGGLCWGMASTYDGSMLAAIEDVVVVTIQ 175

  Fly   289 YRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAP 353
            ||||.|||.|||||::.||:|.|||..|||||..||..|.|:.:.:|:||..|||.|....:|:|
  Rat   176 YRLGILGFFSTGDEHARGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGISVSSHVVSP 240

  Fly   354 QTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVL----GQLLGCSIESSWKLVNCLRTGRSFY 414
            .::.:....|.:||.||....:       .|||.|:    ..|.||....|..|::|||
  Rat   241 MSQGLFHGAIMESGVALLPNLI-------SNTSEVIYTMVANLSGCEPVDSEALMSCLR------ 292

  Fly   415 ELGNAEFSPQVGSFPWGPVLDHNF--TLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYM 477
            |....|.           :..:|.  |:.|        ..|.:||.:.|..|:.:..|: .:..:
  Rat   293 EKSEEEM-----------LAINNIVRTISG--------VVDGKFLPRHPLELLASVDFH-PVPSI 337

  Fly   478 TGVTTQEAAFFVAQNESLSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYEAIK----------- 531
            .|:.:.|..:.:..   |.|         |..::|        :|...:...:|
  Rat   338 IGINSDEYGWIIPM---LHP---------DSTMKE--------INRETMRAVLKNTAVQMMLPPE 382

  Fly   532 ----YIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALN-- 590
                .:..:..|..::..::.|:..|:.|..:..|..|:.... ....|||.|........|.
  Rat   383 CSDLLMEEYMGDTEDSKTLQIQFNEMMGDFIFVIPALQVAHFQ-RSHAPVYFYEFQHQSNFLKDI 446

  Fly   591 LPQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQ 655
            .|...|..|..|..::.|..|.|.:|          ::|:.::.:|...::.:.||||:|||..:
  Rat   447 RPPHVKADHGDELPYVIGYLFWDMKF----------VFTEEEKLLSRKMIKYWANFARHGNPNSE 501

  Fly   656 QVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTECAFWTQYLPTVIGVLVPTYPPTTE 715
               |:.:..|...:.:||.::........|..|:.:  |||:.||..|..|..:....||
  Rat   502 ---GLPYWPALDHDEQYLQLDIQPVVGRALKARRLK--FWTKTLPQKIQELKGSQDNHTE 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	160/591 (27%)
Ces2e	NP_001093947.1	COesterase	30..536	CDD:278561	161/596 (27%)
Ces2e	NP_001093947.1	Aes	<127..>230	CDD:223730	51/103 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336208
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740