Protein Alignment Gli and nlg-1

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_001257226.1
• Gene: nlg-1 / 181484
• WormBaseID: WBGene00006412
• Length: 847
• Species: Caenorhabditis elegans
• Alignment Length: 914
• Identity: 219/914 - (23%)
• Similarity: 348/914 - (38%)
• Gaps: 262/914 - (28%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |||::|.|:| :|...:..|               :...:.:|||||.:.||.:.||........
 Worm    23 VTTSWGMVRG-EVVSPEGDD---------------LPPVAQYLGIPYGVAPTGQYRFNMAISAAK 71

  Fly   202 WQLL--QAVDFGPACPQ-------------PVRYTGATK---------GIMDMDEDCLYLNVYSP 242
            |..:  .|....|.|.|             ..::|.|.:         .:....|||||:|:|.|
 Worm    72 WTHMPKDARKVSPVCIQTDMPELSETKRFRAFKHTSAQRFDFNHRLLPHLKKQSEDCLYMNIYVP 136

  Fly   243 KTGAGVAQKY-PVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENS-P 305
            :........| ||||.:||.|:..|..|.|.|..||::..::|||||||||..|||...:.:| .
 Worm   137 ERLEISRDNYLPVMVIVHGEEYGWGTGNAFNGTTLAAYGHIIVVTLNYRLGVFGFLGRCESSSCS 201

  Fly   306 GNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQT---RNIVRRVIAQSG 367
            ||.||.|...||..:...:..|.||..|:||.|.|:|.:...|||.:|.|   |.:.||.|...|
 Worm   202 GNSGISDLVSALTMLNVILPSFGGDSKSVTLAGWGSGASLVSLLMASPLTQPGRRLFRRAILLDG 266

  Fly   368 SALADWALIQD--KYRAQNTSRVLGQLLGCSIE---SSWK-----LVNCLRTGRSFYELGNAEFS 422
            |||:.||:.|:  :|..|     |.:.|.|:.:   ||:.     :|.|::. .|...:..|...
 Worm   267 SALSPWAISQNPQQYFMQ-----LAEELACAPKNRTSSFNDNVDTIVRCMQV-HSSENITKAVLK 325

  Fly   423 PQVGSFPWG--PVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEA 485
            ..|.:|..|  |::|... :|        .:....|.||       .|...|.|..:.|:::..:
 Worm   326 IDVPTFLSGFAPIVDGQL-IP--------NKPQVSFSTQ-------YGSLFREIDLLVGISSNPS 374

  Fly   486 AFFVAQNESLSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNN-TIIRDQ 549
            ...:: ||.|......:.|   .:|...:.|..|..:...:..:|...||.|.:|.:: ..||:.
 Worm   375 HHMIS-NEDLKVGISKEKR---MRIFRSLVRNLYDFHREEILASIINEYTDWENPRDHPKSIRNG 435

  Fly   550 YINMLSDLYYRAPVDQMVKL----MLEQKVPVYMYVLNTTVEALNLPQW-RKYPHDIERYFLTG- 608
            .:|.|||:.|.||:.:.::.    .:.::...:|:..     |.....| ::.|:...|..|:|
 Worm   436 VLNALSDVLYTAPLIETLRSHSADEVRKEANTFMFAF-----AHETRSWSQEQPNSGIRGSLSGD 495

  Fly   609 -APFM--------DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQR 664
             .|::        |:|     |.|.....|| |:.:|...|...:||.:.|:|:....:..:|.
 Worm   496 IVPYIFGYPLAQGDSE-----ERLYSGFNTD-DKGISKVMMHYVSNFVKSGDPSKPNPMSKNFP- 553

  Fly   665 AYQGEI---------------RYLNINTTYNSSILLNYRQTECAFWTQYLPTV---------IG- 704
              .|::               .||.|  |....:...||..:..||..::|.:         :|
 Worm   554 --MGDVFHSTAWPQFDQPNREAYLEI--TDRPRVKNYYRNAQVGFWNNFIPQLHKNGKETEPVGE 614

  Fly   705 --------------------------------VLVPTYPPTTEYWWEPK------------EPLQ 725
                                            .:.|:.||  |...:||            |..:
 Worm   615 EHHLLSDHFRKDSYFGKTRHFSSYANLPFPPPPMPPSPPP--ELTTKPKPSESPTTLQTTTESEK 677

  Fly   726 IAFWSMS---------VACFFLIVLVVICCIM------WRNAKRQSDRF------YDEDVFINGE 769
            .|..|.:         :.|.|||:.|   |::      |...:|...:|      |:.:   :|.
 Worm   678 AAAGSFTGKALGGVIFIGCGFLIMNV---CLLIAVRREWGKKRRNEKKFQLQYQTYNSN---HGG 736

  Fly   770 GLE--------------PEQDTRGVDN---AHMV------TNHHALRSRDNIYEYRDSPSTKTLA 811
            |.|              |.....||.:   .|.|      :..|....|.:..|....|    |.
 Worm   737 GAEQYNSLNSPLSLMPPPPPPLNGVHDDIFDHRVPHLRNGSTVHGTLPRHSFQEQAREP----LL 797

  Fly   812 SKAHTDTTSLRSPSSLAMTQKSSSQASLKSGISLKETNGHLVKQSERAATPRSQQNGSTAKVASP 876
            |.:|.::||:| |:.::.|.....:|:|                    |...|:.|..||..| |
 Worm   798 SASHKNSTSMR-PAGISPTCPRHGRAAL--------------------ALQNSRGNSLTAAQA-P 840

  Fly   877 PVEE 880
            .:||
 Worm   841 TLEE 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	165/629 (26%)
nlg-1	NP_001257226.1	COesterase	22..595	CDD:365897	165/629 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28602
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030