Protein Alignment Gli and cest-9.1

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_001359584.1
• Gene: cest-9.1 / 181383
• WormBaseID: WBGene00007692
• Length: 614
• Species: Caenorhabditis elegans
• Alignment Length: 696
• Identity: 149/696 - (21%)
• Similarity: 248/696 - (35%)
• Gaps: 182/696 - (26%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            :.|:||:::|..|:..|..             .|.|     |..:|:|.||....||..|:....
 Worm    21 IQTSYGKLRGITVWSNDKN-------------HRYM-----FKSVPFAKPPVGNLRFAKPQNPES 67

  Fly   202 WQ-LLQAVDFGPACPQPVRYTGATKGIMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIR 265
            |. :|.|..:.|||......|...:  ....|||||:|:::.:  ..:..|.||:||.|||.:..
 Worm    68 WSGILDASKYSPACMSNSSSTSTPQ--KHYSEDCLYINIFTSE--KCLNSKCPVIVYFHGGAYNL 128

  Fly   266 GASNLFQGHILASFY---DVVVVTLNYRLGALGFLSTGDEN-SPGNYGILDQAMALRWVYDNIEF 326
            .::.:|....:...|   |||.|....|||..|.|..|..: ...|..:.|...||.:|:..|.:
 Worm   129 DSAIMFNDTFILDRYAAEDVVFVIPAVRLGVFGQLYFGPSDLLSENLFLYDAVQALSFVHSEINY 193

  Fly   327 FNGDRNSITLFGPGAGGASAGLL----MVAPQTRNIVRRVIAQSGSALADWALIQD-------KY 380
            |.||...:|..|..:||.....|    ::.|..:...:.::..:......:.::.|       |:
 Worm   194 FGGDSKRVTAMGHSSGGTIVDALGFSKLIDPGVKLFQQMIVLSATGMFGFYDMVVDNSFAIVEKF 258

  Fly   381 RAQNTSR------VLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFPW----GPVLD 435
            ...|.::      .:.::|.|..:...:  ..|...|...|:.:.:|...:...|:    |.:.|
 Worm   259 GCYNGTKDDRPNANIAEMLDCMRQIDGR--EMLLMQRHMEEVDDRDFRSVLRGAPFLESNGKIAD 321

  Fly   436 HNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYE 500
                                 |.::|.        :||:.|  |.|..|    ....:.::||
 Worm   322 ---------------------LKKSPP--------SRNLLY--GTTEHE----FRNVDHMNPY-- 349

  Fly   501 LDGRFFDQKIREHVFRY-------NYTLNPNGVYEAI-----------------KYIYTFWPDPN 541
            :.|.|.|......|.||       |.....||...||                 .|::.....|.
 Worm   350 ISGIFLDFDNPVAVARYYDEQLMANLETMINGDAAAIFICASTFSTAMANTGADVYLFETRQKPY 414

  Fly   542 NNTIIRDQY-INMLSDLYYRAPVDQM----VKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDI 601
            :..:...|| :.:..::|:|..:|.:    .||:           :|.|...:..|:|.  |.|.
 Worm   415 SFHVSDMQYFVGIHREIYHRPDMDILDTFYSKLL-----------VNFTKMGVPSPEWA--PLDP 466

  Fly   602 ER--YF-------LTGAPFMDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQV 657
            ||  |.       :...|.|...|..|:..|......:.|||::..         |.....|.:.
 Worm   467 ERMNYLELKVDSDMKEGPVMLEGFHEKEMELWFGEMMEFDRNVTKI---------RQSQGLPPEH 522

  Fly   658 LGMHFQRAY-----QGEI------RYLNINTTYNSSILLNYRQTECAFWTQYLPTVIGVLVPTYP 711
            |.:..|..|     :.||      .:.:|:...||    |...|..:..:..|.....:|
 Worm   523 LDIETQLKYWETTNKPEILTKTTKGFTSIHQDNNS----NTVTTTASAQSSLLKNGSSIL----- 578

  Fly   712 PTTEYWWEPKEPLQIAFWSMSVACFFLIVLVVICCIMWRNAKRQSD 757
               :.||         |:.:......|:||:|||.   |..||:.:
 Worm   579 ---KQWW---------FYLIIFLMILLVVLIVICL---RKPKREEE 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	135/632 (21%)
cest-9.1	NP_001359584.1	Abhydrolase	19..498	CDD:389770	119/550 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900