DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gli and cest-16

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_741812.2	Gene:	cest-16 / 180905	WormBaseID:	WBGene00020330	Length:	697	Species:	Caenorhabditis elegans

Alignment Length:	748	Identity:	193/748 - (25%)
Similarity:	308/748 - (41%)	Gaps:	195/748 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 LERDVFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKP 195
            ||:...|....|.|:| .:|   |.|.|               ...:|.|:|||.||..|.||||
Worm    20 LEKSRSVWVEQGLVRG-NIY---NIDGK---------------HIQIFRGVPYAEPPIGELRFKP 65

  Fly   196 PRVHRGW-QLLQAVDFGPACPQPVRY---TGATKGIMD-MDEDCLYLNVYSPKTGAGVAQKYPVM 255
            |.....| |.|.||::||.|.|.:.:   ....|..|| ..||||||||:||......::.||::
Worm    66 PVKKTRWHQELPAVEYGPPCLQFMDFHKNDKFAKTNMDRQSEDCLYLNVFSPYDTDDESKTYPIL 130

  Fly   256 VYIHGGEFIRGASN------LFQGHILASFYDVVVVTLNYRLGALGFLS--TGDENSPGNYGILD 312
            |:||||.|:.|:::      :...:|::.  .:..|::|||||.|||::  .||: ..||:||.|
Worm   131 VWIHGGSFLAGSADTGIDMEVIAANIVSK--GIAFVSINYRLGPLGFMNYQNGDK-LEGNFGIWD 192

  Fly   313 QAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWAL-- 375
            ..|||:|:..||:.||||...:|:.|..||||::.||.::|:|..::.:.|..|||::|.||:
Worm   193 MVMALQWIQSNIKQFNGDPTKVTVMGESAGGAASSLLALSPKTSGLLHQAIIMSGSSMAGWAIHR 257

  Fly   376 -IQDKYRAQN---------------TSRVLGQ--------------------LLGCSIESSWKL- 403
             .|..|...|               |..|:|.                    .:.|..:...::
Worm   258 HSQPAYSVDNLVAYFRCEKWINEDDTKEVVGDEYQHLTHSVIRSALCNYQNVKINCLTDDMTQMD 322

  Fly   404 -VNCLRTGRSF----------YELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFL 457
             :||||...:|          .|||.::.           |:|      ||
Worm   323 KMNCLRKELNFSSPLFRKALAAELGVSKM-----------VVD------GD-------------- 356

  Fly   458 TQTPETLIRAGKFNRNIQYMTGVTTQE-----AAFF-VAQNESL------SPYYELDGRFFDQKI 510
             ..|.:.:...:.|..|..||||..:|     |.|: :.|.:.|      ...|.:....|.:..
Worm   357 -LVPSSGVSLVRNNARIPIMTGVARKEWGHKKAMFYNMHQRDGLKRSDVEEQVYRIIDNSFHETA 420

  Fly   511 REHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQYINML----SDLYYRAPVDQMVKLML 571
            .|.:......|..|..  .::|:.|    |||. .|.||.:..|    ||:.:.||.::.|...:
Worm   421 SEKLANSTVQLIANAT--IVRYLET----PNNE-FIADQVVGALQKLESDIEFVAPCEREVAAYV 478

  Fly   572 EQKVPVYMYVLNTTVEALNLPQWRKY-------PHDIER----YFLTGAPF--MDTEFFPKK--- 620
            ::.||||:|..:...::..|...||.       |.:::|    ..|..|.|  :|..|...|
Worm   479 DKGVPVYLYSFDYVPKSPILESERKIYSLFGTKPVEMKRTEKSEILEKAAFHGLDHAFIFSKGYS 543

  Fly   621 EHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQ-------------RAYQGEIRY 672
            .:.:.:.:|..:..||.......|||.:.|:|:..:.....|.             :..:|||.:
Worm   544 SNFEISPYTKREETMSKILCTMLTNFVKNGDPSTTRFSWPIFSGNSSQYVSLDVPLKLLEGEIHF 608

  Fly   673 LNINTTYNSSILLNYRQTECAFWTQYLPTVIGV-LVPTYPPTTEYWWEPKEPLQIAFWSMSVACF 736
            .:          ..:..||....|:|:...... |.|....|.|      |.:|::.:..|....
Worm   609 PD----------AQFWNTEAELITRYVSKDSETDLDPDADLTNE------ERVQLSAYRRSWYAL 657

  Fly   737 FLIVLVVICCIMWR--------NAKRQSDRFYD 761
            :::| :::..::|.        .:|...:|.||
Worm   658 WVLV-IILSLLIWAFVGYCAYYKSKSPRNRPYD 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	176/668 (26%)
cest-16	NP_741812.2	Abhydrolase	25..608	CDD:389770	174/643 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910