Protein Alignment Gli and cest-2.3

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_506510.2
• Gene: cest-2.3 / 179918
• WormBaseID: WBGene00013873
• Length: 665
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 141/589 - (23%)
• Similarity: 222/589 - (37%)
• Gaps: 176/589 - (29%)

  Fly   161 YRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGWQ-LLQAVDFGPACPQPVRYTGAT 224
            |.|:.:..      .:|||||||..||..|.||:.||:.:.|: :|:..|:.|||....|.|...
 Worm    36 YSPFGNQT------ATVFLGIPYVEPPIGELRFRKPRLLKSWEGVLETKDYKPACMSYWRKTFKN 94

  Fly   225 KGIMDMDEDCLYLNVYSPKTGAGVAQKY-------PVMVYIHGGEFIRGASNLFQGHILASFY-- 280
            ..:.::.|||||.||::        .:|       .||:.:|||..:..:.:.|:..|..:.:
 Worm    95 GFVGEISEDCLYANVFT--------NQYCLQNKNCSVMIVVHGGRLVCESGSAFKPEIFINNFVG 151

  Fly   281 ---DVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAG 342
               ::||||.|||||..||.....|....|..:.|...|::||...|:.|.|:::.||:.|..||
 Worm   152 QDRNIVVVTFNYRLGVFGFGVFNGETGDTNVAMYDMLEAVKWVRKEIDQFGGNKDRITMAGHSAG 216

  Fly   343 GASAGLLM---VAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTS--RVLGQLLGCSIESSW- 401
               |||::   .:..::.::.:.|..|       |.:||..::.|..  .::.|.:|| |...:
 Worm   217 ---AGLIVDFTSSTLSKGLLHQQIVMS-------APLQDISKSANFKGMTIVAQNVGC-IPKEYG 270

  Fly   402 ----------KLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRF 456
                      |...||: .:|..:|.:|:.|.|..|                .:|.|....|..|
 Worm   271 FRKLSKTQINKTYLCLQ-NKSAQDLLHAQLSMQQNS----------------TFYFGSPRVDGDF 318

  Fly   457 LTQTPETLIRAGKFNRNIQY----MTGVTTQEA--AFFVA--QNESLSPY----------YEL-- 501
            :|..|:.|     ||.|..|    ..|.||.|.  :.::.  :|:.:...          |||
 Worm   319 ITDYPDNL-----FNFNTIYPINTFIGTTTGELRDSLYITDPKNDRIKEQLLKNMCEHVGYELFE 378

  Fly   502 -----------------DGRFFD----------------QKIREHVFRYNYTLNPNGV------- 526
                             |.:|..                ::....||.|:|.....|.
 Worm   379 KPEEFTKKCGNYYKNGTDAQFLSDDMEFYSGAIKVANAHKRANSKVFMYSYDYKGAGTAFHKYLE 443

  Fly   527 ----YEAIKYIYTF----WPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLN 583
                :.:...||||    .|....:.:|...|..||::.           :..|...|
 Worm   444 APSPHHSEDLIYTFGTSRGPFVAKDYVIERIYSGMLANF-----------INFEDPSP------- 490

  Fly   584 TTVEALNLPQWRKYPHDIERYFLTGAPFMDTEF-FP-KKEHLQR---NMW-TDNDRNMSHFFMQT 642
                 ....|||:|..:...|||..   .|..| .| .|:|...   :.| |...::.|..|..:
 Worm   491 -----SKTQQWRQYTQEKREYFLID---FDKNFTMPGMKDHYYTRALDFWSTAGKKSFSERFSPS 547

  Fly   643 YTNF 646
            ..||
 Worm   548 LDNF 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	141/589 (24%)
cest-2.3	NP_506510.2	Abhydrolase	20..532	CDD:389770	135/568 (24%)
		CemA	<550..>647	CDD:383495	2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860