Protein Alignment Gli and cest-2.2

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_001256567.1
• Gene: cest-2.2 / 179917
• WormBaseID: WBGene00013874
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 740
• Identity: 153/740 - (20%)
• Similarity: 254/740 - (34%)
• Gaps: 227/740 - (30%)

  Fly   177 VFLGIPYALPPTFEGRFKPPRVHRGWQ-LLQAVDFGPAC--PQPVRYTGATKGIMDMDEDCLYLN 238
            ||.|:||..||....||:.||..:.|. :|:|.::..||  .|...|.....|  .:.|||||.|
 Worm    48 VFFGVPYVEPPVGNLRFRKPRPPKPWDGVLEAKEYKAACMSDQKKTYKNGVGG--PVSEDCLYAN 110

  Fly   239 VYSPKTGAGVAQKY-------PVMVYIHGGEFIRGASNLFQGHILASFY-----DVVVVTLNYRL 291
            |::        .:|       .||:.||||.|:..:::.:...|:.:.:     ::||||.||||
 Worm   111 VFT--------NQYCLEHKNCSVMLTIHGGRFVIESASAYDPEIIINNFVGQGRNIVVVTFNYRL 167

  Fly   292 GALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTR 356
            |..|......:|...|:|:.|....:||....|:.|.||::.||:.|..||.........:|.::
 Worm   168 GLFGLGMLNGDNQDTNFGLYDILEVVRWTRKEIKNFGGDKDRITMQGHSAGAVFTAAFSTSPLSK 232

  Fly   357 NIVRRVIAQSGSALADWALIQDKYRAQNTSR--VLGQLLGC-----------SIESSWKLVNCLR 408
            .::.:.|..|.|       :.:..:..|...  |:.:::||           ::|.. |...|||
 Worm   233 GLIHQQIIMSAS-------MSNLSKKSNVKELTVVARIVGCLPDEHGFPKLSNVEVE-KAYTCLR 289

  Fly   409 TGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRN 473
            : :|..::.:|:.                :.|....:|.|....|..:....|:.|...... ..
 Worm   290 S-KSAQQILDAQL----------------YMLRNTTYYIGQGHIDGIYQVDYPDNLYATNSI-YP 336

  Fly   474 IQYMTGVTTQEAAFFVAQNESLSPYYELDGRFFD------------QKIREHVFRYNYTLNPNGV 526
            |..|.|.||.|.               :|.|:..            |.:.||: .|.....|...
 Worm   337 INTMIGTTTAEL---------------MDSRYIVDPKNTGKKEILLQNLCEHI-GYELYKEPEEF 385

  Fly   527 YEAIKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNL 591
            .:..:..|....|..:   :.|.     .:.||.|  .|:..:...:...|::|..:.. ||.|
 Worm   386 SQKCRNFYKNGEDAKS---LGDD-----MEFYYGA--IQLANVHSSKDTNVFVYSFDYK-EAGN- 438

  Fly   592 PQWRKYPHDIERYFLTGAPFMDTEFFPKKEH-------LQRNMWTDNDRNMSHFFMQTYTNFARY 649
             .::||               |....||...       ..|..::..|..:.:.:...:.:|..:
 Worm   439 -AYKKY---------------DKSLSPKHGEDFAYAFGTNRGNFSTKDYVIEYIYSGMFADFVNF 487

  Fly   650 GNPTPQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTECAFWTQYLP-------------- 700
            |:|:|                                   .|...|.||.|
 Worm   488 GDPSP-----------------------------------LEDQEWAQYTPEKREYFLIDFDKNF 517

  Fly   701 TVIGVLVPTYPPTTEYWWEPKEPLQIAFWSMSVACFFLIVLVVICCIMWRNAKRQSDRFYDE-DV 764
            |:.|:....||...|:|               ..|               .:|...:.|... |:
 Worm   518 TMPGMKDHYYPKALEFW---------------STC---------------GSKSFKEHFSPSVDI 552

  Fly   765 FINGEGLEPEQDTRGVDNAHMVTNHHALRSRDNIYEYRDSPSTKTLASKAHTDTTSLRSPSSLAM 829
            ||.|..|.|..       :|:  ||:. ...|..:|..|.     |.::.......|::...|.:
 Worm   553 FIIGNLLNPIM-------SHL--NHNE-TGPDKTFEQFDK-----LYNEREEFLKLLKAVRKLEI 602

  Fly   830 TQK-----SSSQASLKSGISLKETN 849
            .:|     ||....||..:.|::.|
 Worm   603 QKKMWRGRSSKDLMLKELVDLEKIN 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	118/564 (21%)
cest-2.2	NP_001256567.1	Abhydrolase	25..534	CDD:389770	127/600 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.870