Protein Alignment Gli and cest-1.2

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_506504.2
• Gene: cest-1.2 / 179914
• WormBaseID: WBGene00011364
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 666
• Identity: 149/666 - (22%)
• Similarity: 245/666 - (36%)
• Gaps: 185/666 - (27%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |..:.|.::|.::        .|.|.|:.:.      ....||||||..||..:.||:.||..:.
 Worm    21 VQLSTGIIEGKQL--------NSTYSPFGNQ------SAIAFLGIPYVEPPIGDLRFRKPRPQKT 71

  Fly   202 WQ-LLQAVDFGPACPQPVRYTGATKGI-MDMDEDCLYLNVYSPKTGAGVAQKY-------PVMVY 257
            |. :|:...|.|||......|....|| ..:.||||||||        :..:|       .|::.
 Worm    72 WSGVLETKKFKPACMSNSTKTYKNGGIGGPISEDCLYLNV--------LTNQYCLENKNCSVVII 128

  Fly   258 IHGGEFIRGASNLFQGHILASFY-----DVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMAL 317
            :|||.::..::..|...||.:.:     ::||||:|||||..||..........|.||.|...|:
 Worm   129 VHGGGYLFESAATFNHEILVNNFVGQDRNIVVVTINYRLGIFGFGHLNGFEGDKNVGIFDTLEAV 193

  Fly   318 RWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRA 382
            :||...|:.|.|:::.|||.|..||........::|.|:.::.:.|..||.             .
 Worm   194 KWVRREIKQFGGNKDRITLAGHSAGAGVVAAFTISPLTKGLIHQQIVMSGP-------------M 245

  Fly   383 QNTSR--------VLGQLLGC-------------SIESSWKLVNCLRTGRSFYELGNAEFSPQVG 426
            .|.|:        .:.:.:||             .:|   ::.:|||. :...||.:|:.
 Worm   246 TNMSKKSNFKGMTAMAERVGCHSKKYGFNKLPEHEVE---QVYSCLRK-KPAQELLDAQL----- 301

  Fly   427 SFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTT---QEAAFF 488
               |        .|....:|.|....|..|:|..|:.|. :.|...:|..:.|.||   |:..:.
 Worm   302 ---W--------LLQNSTFYFGAPPVDGEFITDYPDNLY-SEKSIFSINTLLGTTTRELQDTGYI 354

  Fly   489 VAQNES-----------------LSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYEAIKYIYTF 536
            ...|.|                 :..|.|.:.  |..|.::.   |....:...:.:.::: ||
 Worm   355 SNSNYSKFETKETFLKNLCDQIGIEIYKESED--FSSKCQKW---YINGSDSKSLSDDMEF-YT- 412

  Fly   537 WPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKY---- 597
                        |.|| |:|.:.|.          .:||.:|.|..:...     |.::||
 Worm   413 ------------QAIN-LADAHARK----------GKKVYMYSYAYSGAG-----PAFKKYMKVK 449

  Fly   598 -PHDIERYFLTGAPFMDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMH 661
             ||..|....|..             ..|.::...|..:.:.:...:.:|..:.:|:|.
 Worm   450 SPHHSEDLIYTFG-------------THRGVFAPKDYVIEYIYSGMFADFINFEDPSPS------ 495

  Fly   662 FQRAYQGEIRYLNINTTYNSSILLNYRQTECAFWTQYLPTVIGVLVPTYPPTTEYWWEPKEPLQI 726
               ..|..::|...|..|   .|:::.|.         .|:.|:....|....|:|....:....
 Worm   496 ---TDQPWLQYTKENKEY---FLVDFDQN---------LTMPGMKKNYYAKAYEFWSTAGQKSFK 545

  Fly   727 AFWSMSVACFFLIVLV 742
            ..||.|:..|.:..||
 Worm   546 EEWSPSLDTFIITNLV 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	138/617 (22%)
cest-1.2	NP_506504.2	COesterase	21..536	CDD:278561	142/639 (22%)
		Aes	<125..>250	CDD:223730	40/137 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770