Protein Alignment Gli and cest-17

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_505114.1
• Gene: cest-17 / 179198
• WormBaseID: WBGene00019477
• Length: 571
• Species: Caenorhabditis elegans
• Alignment Length: 598
• Identity: 159/598 - (26%)
• Similarity: 252/598 - (42%)
• Gaps: 100/598 - (16%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |||.||.:.||:               :.|||  ...:..|||||.|..||....||:.|.....
 Worm    24 VTTPYGPIVGFE---------------HKSTV--TGSKYHVFLGIRYGNPPDHIYRFQKPEPVEK 71

  Fly   202 WQLL--QAVDFGPACPQPVRYTGATKGIMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFI 264
            |..:  .|..|..:|...:|  ...:..::..||||:||:.:|....  .:|.||:|:||||.|.
 Worm    72 WPHINHDATHFRASCIPSLR--SELEEQVNYSEDCLFLNIVTPPDAK--EKKLPVLVFIHGGGFQ 132

  Fly   265 RGASNLFQGHILASFY---DVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEF 326
            .|.:::......|..:   |::.|::.||||.|||.:|||...|||.|:.||.:||:::::.:..
 Worm   133 FGDTSMIGYQKAADNFVSKDIIFVSIQYRLGPLGFFTTGDSEIPGNMGLWDQTLALQFLHEVLPD 197

  Fly   327 FNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQ 391
            |.||.:.|||.|..||.||...|:.:|.:.::..:.|..|||..::..|.::   ..:.||.|.:
 Worm   198 FGGDPDRITLAGHSAGAASVSALLYSPHSDHLFSQAIQLSGSIFSESNLDRN---VVDDSRKLAK 259

  Fly   392 LLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPG--DDWYEGWREKDW 454
            ..||..|.|.:|.:|:.. |:..||.:|..|  :|..           |||  ...:..:.:||
 Worm   260 AAGCPQEDSKELRDCIEI-RTVDELLDAMES--IGEL-----------LPGPRTKKFHPYFDKD- 309

  Fly   455 RFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFV-----------AQNESLSPYYE--LDGRFF 506
             |.....|.:.|.....|.:|   |:.:.|:...|           ...||.|.|.:  |.....
 Worm   310 -FFPYDIEKMSRKAPKKRTMQ---GLVSLESGLSVLYPVKLAKLLGVPKESWSTYSKDNLVDFIR 370

  Fly   507 DQKIREHVFRYNYTLNPNGVYEA-----IKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQM 566
            .|...|..|         |...|     ::..|...|...|::...:.:.|:||||.|..|....
 Worm   371 SQVAVEQEF---------GTASARFSGLVEEFYLSGPMTGNSSFYLNAFANLLSDLQYNIPTLHE 426

  Fly   567 VKLMLEQKVPVYMYVLNTTVEALNLPQWRKYP-----HDIERYFLTGAPFMDTEFFPKKEHLQRN 626
            |:|.|:.....|:|:::...|....|   .:|     |..|..:|.....|||..|
 Worm   427 VELKLQHGWDTYLYIIDYDSETTKDP---THPIKGPFHASELRYLFNFNGMDTIPF--------- 479

  Fly   627 MWTDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTE 691
              .|.|:...::|:....||...|.|:.:.:|.....::..    :.|:......|:..::||..
 Worm   480 --NDKDKKFENYFVNAIVNFINTGTPSTKALLWPAVSKSQP----FANLLLNDKPSVQTSFRQEA 538

  Fly   692 CAFWTQYLPTVIG 704
            ...|...:...:|
 Worm   539 YELWQSDIAKTVG 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	157/587 (27%)
		PRK13335	818..>918	CDD:139494
cest-17	NP_505114.1	COesterase	22..542	CDD:395084	157/587 (27%)