Protein Alignment Gli and cest-6

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_501070.1
• Gene: cest-6 / 177459
• WormBaseID: WBGene00020688
• Length: 583
• Species: Caenorhabditis elegans
• Alignment Length: 691
• Identity: 148/691 - (21%)
• Similarity: 262/691 - (37%)
• Gaps: 196/691 - (28%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            :||:.|.:.|.::                       |....|..||:|.||..:.||:.|.....
 Worm    26 ITTSLGSINGNQI-----------------------GSYQTFKKIPFAKPPIGKLRFQKPMAAEK 67

  Fly   202 WQ-LLQAVDFGPAC-------PQPVRYTGATKGIMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYI 258
            |: :|.|.::||||       ..|.::         :|||||::|:::..|... ::...|:.|:
 Worm    68 WEGILNATEYGPACMSNSSTSKSPQKW---------IDEDCLHINIFTTDTCLS-SKNCSVVFYV 122

  Fly   259 HGGEFIRGASNLFQGHILASFY---DVVVVTLNYRLGALGFLSTGDEN-SPGNYGILDQAMALRW 319
            ||||.:..::.:|:...|...:   ||::|...:|||........|:| :|.|..:.|..:||.:
 Worm   123 HGGELVYDSAVMFEDKYLFDTFSSRDVILVIPAFRLGLFSHFVVEDQNVAPNNLALYDILLALEF 187

  Fly   320 VYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTR---NIVRRVIAQSGSALADWALIQDKYR 381
            |...|..|.|..:.:|.||...||....::..:.:..   :..:|||..  |::..|..::  :.
 Worm   188 VKSEIHNFGGSSDRVTAFGHSYGGHVVSVMAFSTEINTDLSYFQRVICM--SSVNVWDSLE--FE 248

  Fly   382 AQNTSRVLGQLLGCSIESSWK-----------LVNC---------LRTGRSFYELGNAEFSPQVG 426
            .:.|.|.: |...||:....|           ::.|         ||..||..:.|:..:|..|.
 Worm   249 IEKTMRFI-QYANCSVPQDLKSRMTSFEQDSYMMECLQDIDSMELLRIQRSLEDEGHPIYSGLVL 312

  Fly   427 SFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQ 491
            ..|    |..|..:  .|:||            .|          :||..:||.|.:|...|.|.
 Worm   313 REP----LIQNVLV--QDFYE------------KP----------KNIPTLTGCTYKELDKFHAY 349

  Fly   492 N---ESL--SPYYELDGRFFDQKIREHVFRY-NYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQY 550
            :   |:|  ..|.|.|.::.|.:      :| .:.||.:.                      |:.
 Worm   350 HNIVETLGYENYKECDDKYRDDR------KYGRFDLNKHA----------------------DET 386

  Fly   551 INMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYP-HDIERYFLTGAPFMDT 614
            ..:|:..  :..||:    .|::.:|.|.|..:          :.|:| |..:..::.|     .
 Worm   387 FGILAQT--KLKVDK----QLDKGIPTYFYEYS----------YPKHPSHTDDLSYIMG-----V 430

  Fly   615 EFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNI---- 675
            ..|.|.|         |:.:::..:.:.:.||.::|.|      |..|:.:......|.|.
 Worm   431 HAFEKDE---------NEIHLAKSYQEMFMNFVKFGEP------GGGFEMSTFENSSYFNFYWNE 480

  Fly   676 NTTYNSSILLNYRQTECAFWT----QYLPTVIGVLVPTYPPTTEYWWEPKEPLQIAFWSMS---V 733
            .|...||:..|:.:....:|.    :|...:..........|....:...|. |:.:..:|   :
 Worm   481 TTGEKSSMKTNFEKEIIKYWLKDMFEYDQNITAAKQLKVAITRSAKFNVSED-QLPYLYISMLII 544

  Fly   734 ACFFLIVLVV--ICCIMWRNAKRQSDRFYDEDVFINGEGLE 772
            |..||...:|  |||:..|          |..::|..:||:
 Worm   545 ALIFLTGCLVGKICCVQPR----------DRHLYIQLDGLD 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	130/603 (22%)
		PRK13335	818..>918	CDD:139494
cest-6	NP_501070.1	alpha/beta hydrolases	25..500	CDD:473884	130/603 (22%)