Protein Alignment Gli and cest-25

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_497609.1
• Gene: cest-25 / 175390
• WormBaseID: WBGene00022178
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 588
• Identity: 149/588 - (25%)
• Similarity: 228/588 - (38%)
• Gaps: 187/588 - (31%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSV--FLGIPYALPPTFEGRFKPPRVH 199
            |.|:||.::|              .|..|.      ||..|  |.|||||.||....||..|:.|
 Worm    19 VLTSYGPIEG--------------RRLIHE------GEKQVDAFQGIPYAAPPIGNLRFALPQPH 63

  Fly   200 RGW-QLLQAVDFGPACPQPVRYTGATKGIM----------DMDEDCLYLNVYSP------KTGAG 247
            ..| ::.:...||            .:||.          ...||.|.||:::|      :||
 Worm    64 EKWTEVRETKSFG------------ARGIQKDHVLSPKTSPQSEDNLTLNIFTPVWTPKNETG-- 114

  Fly   248 VAQKYPVMVYIHGGEFIRGASNLFQG-----HILASFYDVVVVTLNYRLGALGFLSTGDENSPGN 307
                :||::|||||.|:..:::.:..     |::..  ||||||:.||||.|||.:|||.:.|.|
 Worm   115 ----FPVILYIHGGGFVSDSAHKYGDMSICQHLVTK--DVVVVTIQYRLGFLGFWTTGDSSIPDN 173

  Fly   308 YGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALAD 372
            ..:.|...||:||.:||..||||.|:|||.|..|||||...|.::|.:|::.::||...|:|...
 Worm   174 VALHDMVFALKWVKENIGLFNGDPNNITLMGQSAGGASVDFLSISPVSRDLFQKVIPMGGNASCS 238

  Fly   373 WALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHN 437
            ||:   ..|..|..|...|.:|                                      |.|..
 Worm   239 WAI---HPRPLNACRNRAQEIG--------------------------------------VFDGM 262

  Fly   438 FTLPGDDWYEGWRE--KDWRFL---------TQTPETLIRAGKFN-----RNIQYMT-------- 478
            .||   ||.|..||  .| :|.         |:|...|:...|::     |.:..:.
 Worm   263 NTL---DWVEKLRELPAD-KFASALNMEAVDTKTDPELLIGPKYDNLFIPRPVMELRKEAPMKPR 323

  Fly   479 ---------------GVTTQEAAFFVAQNESLSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYE 528
                           |:.|:.....|.|:.|..    |..:.|..|.|::            ..:
 Worm   324 LLGCAKSEGLVFAFFGLNTKHPLHAVQQDVSAI----LSEKLFPLKARDY------------QEK 372

  Fly   529 AIKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQK--VPVYMYVLNTT------ 585
            |::.:.....|.:.....| ..:::..|.:....:.|.|..:||.:  .|:|||..:..
 Worm   373 ALEKLIEIGTDHSKEEWQR-AMVDLKGDSFLNVGIQQNVLDVLETQPSTPIYMYSFDYCNPKAYG 436

  Fly   586 VEALNLPQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNM-WTDNDRNMSHFFMQTYTNFARY 649
            :....|| ::...|..:..::.|            .|:..:. :.:.|..|.....:.:||||:|
 Worm   437 IMGFKLP-FKDATHCTDISYVVG------------NHIVNSFDFNEEDYKMIEITTRLWTNFAKY 488

  Fly   650 GNP 652
            |||
 Worm   489 GNP 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	149/588 (25%)
cest-25	NP_497609.1	COesterase	18..536	CDD:365897	149/588 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770