DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gli and Nlgn3

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_599163.2	Gene:	Nlgn3 / 171297	RGDID:	621119	Length:	848	Species:	Rattus norvegicus

Alignment Length:	840	Identity:	237/840 - (28%)
Similarity:	341/840 - (40%)	Gaps:	209/840 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |.|::|:::|.:|     |.|           ..::|....:||:|||.||..|.||.||.....
  Rat    44 VNTHFGKLRGARV-----PLP-----------SEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPS 92

  Fly   202 WQ-LLQAVDFGPACPQ-----------PVRYTG-----ATKGIMDMDEDCLYLNVYSP------- 242
            |. :..|..|.|.|||           ||.:|.     ||. |.:.:|||||||||.|
  Rat    93 WSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATY-IQEPNEDCLYLNVYVPTEDVKRI 156

  Fly   243 --------------KTGAGVAQK--------------------YPVMVYIHGGEFIRGASNLFQG 273
                          |.|:|..::                    .|||||||||.::.|..|:..|
  Rat   157 SKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDG 221

  Fly   274 HILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFG 338
            .:|||:.:|:|:|||||:|.||||||||:.:.||||:|||..|||||.:||.||.||...||:||
  Rat   222 SVLASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFG 286

  Fly   339 PGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKL 403
            .|.|.:...||.::..:..:.:|.|.||||||:.||:   .|:....:.:|...:||::..:..:
  Rat   287 SGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAV---NYQPVKYTSLLADKVGCNVLDTVDM 348

  Fly   404 VNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAG 468
            |:|||. :|..||...:..|......:|||:|.: .:|.|                 ||.|:..|
  Rat   349 VDCLRQ-KSAKELVEQDIQPARYHVAFGPVIDGD-VIPDD-----------------PEILMEQG 394

  Fly   469 KFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELDGRFFDQKIREHVFR-YNYTLNPNGVYEAIKY 532
            :| .|...|.||...|...||  ...:.|...:.|..||..:...|.. |.|....:.:.|.||:
  Rat   395 EF-LNYDIMLGVNQGEGLKFV--EGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKF 456

  Fly   533 IYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKY 597
            :||.|.|.:|....|...:.:.:|..:..|......|......|.|.|......::|..|.|...
  Rat   457 MYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDA 521

  Fly   598 PHDIERYFLTGAPFM-DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVL 658
            .|..|..::.|.|.: .|:.||..       ::.||..:|...|..:||||:.|:   |.||...
  Rat   522 AHGDEVPYVFGVPMVGPTDLFPCN-------FSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTK 579

  Fly   659 GMHFQRAYQGEIR----------YLNINTTYNSSILLNYRQTECAFWTQYLP-----------TV 702
            .:|.:.....|:.          ||:|.  ....:..:||.|:.|||...:|           |.
  Rat   580 FIHTKANRFEEVAWSKYNPRDQLYLHIG--LKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTS 642

  Fly   703 IGVLVPTYPPTTEY-----------WWEPKEP-LQIAF--------W------------------ 729
            ....||  ||.|.:           .|..|.| :..|:        |
  Rat   643 TTTKVP--PPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAPGSWNGDQDAGPLLVENPRDYS 705

  Fly   730 ---SMSVA----CFFLIVLVVICCIMWRNAKRQSDRFYDEDVFINGEGLEPEQDTRGVDNAHMVT 787
               |:::|    ..||.|| ....:.:|..||:.            |.|......||.....:.|
  Rat   706 TELSVTIAVGASLLFLNVL-AFAALYYRKDKRRQ------------EPLRQPSPQRGTGAPELGT 757

  Fly   788 NHH----ALRSRDNIYEYRDSPSTKTLASKAHTDTT----------SLRSPSSLAMTQKS 833
            ...    ||:.....:|....|...||...|..|.|          .|.:|:::.|...|
  Rat   758 APEEELAALQLGPTHHECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNS 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	196/630 (31%)
Nlgn3	NP_599163.2	COesterase	40..624	CDD:395084	196/630 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..195		3/25 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..691		10/47 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920