Protein Alignment Gli and Nlgn3

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_599163.2
• Gene: Nlgn3 / 171297
• RGDID: 621119
• Length: 848
• Species: Rattus norvegicus
• Alignment Length: 840
• Identity: 237/840 - (28%)
• Similarity: 341/840 - (40%)
• Gaps: 209/840 - (24%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |.|::|:::|.:|     |.|           ..::|....:||:|||.||..|.||.||.....
  Rat    44 VNTHFGKLRGARV-----PLP-----------SEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPS 92

  Fly   202 WQ-LLQAVDFGPACPQ-----------PVRYTG-----ATKGIMDMDEDCLYLNVYSP------- 242
            |. :..|..|.|.|||           ||.:|.     ||. |.:.:|||||||||.|
  Rat    93 WSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATY-IQEPNEDCLYLNVYVPTEDVKRI 156

  Fly   243 --------------KTGAGVAQK--------------------YPVMVYIHGGEFIRGASNLFQG 273
                          |.|:|..::                    .|||||||||.::.|..|:..|
  Rat   157 SKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDG 221

  Fly   274 HILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFG 338
            .:|||:.:|:|:|||||:|.||||||||:.:.||||:|||..|||||.:||.||.||...||:||
  Rat   222 SVLASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFG 286

  Fly   339 PGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKL 403
            .|.|.:...||.::..:..:.:|.|.||||||:.||:   .|:....:.:|...:||::..:..:
  Rat   287 SGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAV---NYQPVKYTSLLADKVGCNVLDTVDM 348

  Fly   404 VNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAG 468
            |:|||. :|..||...:..|......:|||:|.: .:|.|                 ||.|:..|
  Rat   349 VDCLRQ-KSAKELVEQDIQPARYHVAFGPVIDGD-VIPDD-----------------PEILMEQG 394

  Fly   469 KFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELDGRFFDQKIREHVFR-YNYTLNPNGVYEAIKY 532
            :| .|...|.||...|...||  ...:.|...:.|..||..:...|.. |.|....:.:.|.||:
  Rat   395 EF-LNYDIMLGVNQGEGLKFV--EGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKF 456

  Fly   533 IYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKY 597
            :||.|.|.:|....|...:.:.:|..:..|......|......|.|.|......::|..|.|...
  Rat   457 MYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDA 521

  Fly   598 PHDIERYFLTGAPFM-DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVL 658
            .|..|..::.|.|.: .|:.||..       ::.||..:|...|..:||||:.|:   |.||...
  Rat   522 AHGDEVPYVFGVPMVGPTDLFPCN-------FSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTK 579

  Fly   659 GMHFQRAYQGEIR----------YLNINTTYNSSILLNYRQTECAFWTQYLP-----------TV 702
            .:|.:.....|:.          ||:|.  ....:..:||.|:.|||...:|           |.
  Rat   580 FIHTKANRFEEVAWSKYNPRDQLYLHIG--LKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTS 642

  Fly   703 IGVLVPTYPPTTEY-----------WWEPKEP-LQIAF--------W------------------ 729
            ....||  ||.|.:           .|..|.| :..|:        |
  Rat   643 TTTKVP--PPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAPGSWNGDQDAGPLLVENPRDYS 705

  Fly   730 ---SMSVA----CFFLIVLVVICCIMWRNAKRQSDRFYDEDVFINGEGLEPEQDTRGVDNAHMVT 787
               |:::|    ..||.|| ....:.:|..||:.            |.|......||.....:.|
  Rat   706 TELSVTIAVGASLLFLNVL-AFAALYYRKDKRRQ------------EPLRQPSPQRGTGAPELGT 757

  Fly   788 NHH----ALRSRDNIYEYRDSPSTKTLASKAHTDTT----------SLRSPSSLAMTQKS 833
            ...    ||:.....:|....|...||...|..|.|          .|.:|:::.|...|
  Rat   758 APEEELAALQLGPTHHECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNS 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	196/630 (31%)
		PRK13335	818..>918	CDD:139494	5/26 (19%)
Nlgn3	NP_599163.2	COesterase	40..624	CDD:395084	196/630 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..195		3/25 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..691		10/47 (21%)