DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gli and Ces1e

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_598421.1	Gene:	Ces1e / 13897	MGIID:	95432	Length:	562	Species:	Mus musculus

Alignment Length:	577	Identity:	172/577 - (29%)
Similarity:	263/577 - (45%)	Gaps:	98/577 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 VDRVMGE--------------CSVFLGIPYALPPTFEGRFKPPRVHRGWQLLQ-AVDFGPACPQ- 216
            ||.|.|:              .:||||:|:|.||....||.||:....|..:: |..:.|.|.|
Mouse    27 VDTVQGKVLGKYISLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSSVKNATSYPPMCFQD 91

  Fly   217 PVRYTG----------ATKGIMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIRGASNLF 271
            ||  ||          ..|..:...|||||||:|:| .....:.:.||||:||||..:.|.::.:
Mouse    92 PV--TGQIVNDLLTNRKEKIPLQFSEDCLYLNIYTP-ADLTKSDRLPVMVWIHGGGLVLGGASTY 153

  Fly   272 QGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITL 336
            .|.:|::..:||||.:.||||..||.|||||:|.||:|.|||..||.||.|||..|.||..|:|:
Mouse   154 DGLVLSTHENVVVVVIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIAKFGGDPGSVTI 218

  Fly   337 FGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSW 401
            ||..|||.|..:|:::|..:|:.:|.|::||.||....:   |...:..:..:..:.||...:|.
Mouse   219 FGESAGGESVSVLVLSPLAKNLFQRAISESGVALTAGLV---KKNTRPLAEKIAVISGCKNTTSA 280

  Fly   402 KLVNCLRTGR-----------SFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWR 455
            .:|:|||...           :.::|.....|.|  |.|:.|.:.....||
Mouse   281 AMVHCLRQKTEEELLGTTLKLNLFKLDLHGDSRQ--SHPFVPTVLDGVLLP-------------- 329

  Fly   456 FLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPY-YELDGRFFDQKIREHVFRYNY 519
               :.||.::....|| .:.|:.|:..||..:.:....:..|. .:||.......:::..|..|
Mouse   330 ---KMPEEILAEKNFN-TVPYIVGINKQEFGWILPTMMNYPPSDVKLDQMTAMSLLKKSSFLLN- 389

  Fly   520 TLNPNGVYEAI-KYI----YTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYM 579
             |..:.:..|| ||:    ||     ..|   :||.:.::.|:.:..|...:.:...:...|.||
Mouse   390 -LPEDAIAVAIEKYLRDKDYT-----GRN---KDQLLELIGDVVFGVPSVIVSRGHRDAGAPTYM 445

  Fly   580 YVL--NTTVEALNLPQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMWTDNDRNMSHFFMQT 642
            |..  :.:..:...|......|..|.|.:.|||.:            |...::.:.|:|...|:.
Mouse   446 YEFQYSPSFSSEMKPDTVVGDHGDEIYSVFGAPIL------------RGGTSEEEINLSKMMMKF 498

  Fly   643 YTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTECAFWTQYL 699
            :.||||.|||..|   |:.....|..:..||.|..|...:..|  ::.|.||||:.|
Mouse   499 WANFARNGNPNGQ---GLPHWPEYDQKEGYLQIGATTQQAQKL--KEKEVAFWTELL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	168/571 (29%)
Ces1e	NP_598421.1	COesterase	25..546	CDD:278561	168/571 (29%)
		Aes	44..>242	CDD:223730	85/200 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255	559..562
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832919
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740