Protein Alignment Gli and Ces1c

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_031980.2
• Gene: Ces1c / 13884
• MGIID: 95420
• Length: 554
• Species: Mus musculus
• Alignment Length: 603
• Identity: 171/603 - (28%)
• Similarity: 275/603 - (45%)
• Gaps: 106/603 - (17%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |.|..|:|.|..:.:      :.|.:|           .:||||:|:|.||....||.||:....
Mouse    26 VDTTQGKVLGKYISL------EGFEQP-----------VAVFLGVPFAKPPLGSLRFAPPQPAEP 73

  Fly   202 WQLLQ-AVDFGPACPQPVRYTGATKGIMDM------------DEDCLYLNVYSPKTGAGVAQKYP 253
            |..:: |..:.|.|.|.   .|..|.:.||            .|||||||:||| .....:.:.|
Mouse    74 WSFVKNATSYPPMCSQD---AGWAKILSDMFSTEKEILPLKISEDCLYLNIYSP-ADLTKSSQLP 134

  Fly   254 VMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALR 318
            |||:||||..:.|.::.:.|..|::..:|||||:.||||..|..|||||:||||:..|||..|||
Mouse   135 VMVWIHGGGLVIGGASPYNGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSPGNWAHLDQLAALR 199

  Fly   319 WVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQ 383
            ||.|||..|.|:.:|:|:||..:||.|..:|:::|..:::..|.|::||..:....   .|...|
Mouse   200 WVQDNIANFGGNPDSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVINTNV---GKKNIQ 261

  Fly   384 NTSRVLGQLLGCSIESSWKLVNCLR--TGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWY 446
            ..:.::..|..|:..||..:|.|||  |.....|:.             |.::.:|.:|.
Mouse   262 AVNEIIATLSQCNDTSSAAMVQCLRQKTESELLEIS-------------GKLVQYNISLS----- 308

  Fly   447 EGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQN-ESLSPYYELDGRFFDQKI 510
               ...|...|.:.||.::....|| .:.|:.|...||..:.:... ::|.|    :|:..::..
Mouse   309 ---TMIDGVVLPKAPEEILAEKSFN-TVPYIVGFNKQEFGWIIPMMLQNLLP----EGKMNEETA 365

  Fly   511 REHVFRYNYTLN------PNGVYEAIKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKL 569
            ...:.|::..||      |..:.:.::.:    .||...:   :..::|..|:::..|...:.:.
Mouse   366 SLLLRRFHSELNISESMIPAVIEQYLRGV----DDPAKKS---ELILDMFGDIFFGIPAVLLSRS 423

  Fly   570 MLEQKVPVYMYVLNTTVEALN--LPQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMWTDND 632
            :.:..|..|||........::  .||..:..|..|.:|:.|||.:       ||..     ::.:
Mouse   424 LRDAGVSTYMYEFRYRPSFVSDKRPQTVEGDHGDEIFFVFGAPLL-------KEGA-----SEEE 476

  Fly   633 RNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTECAFWTQ 697
            .|:|...|:.:.||||.|||..:   |:.....|..:..||.|..|...:..|  :..|.||||:
Mouse   477 TNLSKMVMKFWANFARNGNPNGE---GLPHWPEYDEQEGYLQIGATTQQAQRL--KAEEVAFWTE 536

  Fly   698 YLPTVIGVLVPTYPPTTE 715
                    |:...||.|:
Mouse   537 --------LLAKNPPETD 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	164/581 (28%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	161/570 (28%)
		Aes	<121..>234	CDD:223730	54/113 (48%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832556
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740