Protein Alignment Gli and Cel

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_034015.1
• Gene: Cel / 12613
• MGIID: 88374
• Length: 599
• Species: Mus musculus
• Alignment Length: 591
• Identity: 172/591 - (29%)
• Similarity: 260/591 - (43%)
• Gaps: 111/591 - (18%)

  Fly   177 VFLGIPYALPPTFEGRFKPPRVHRGWQ-LLQAVDFGPACPQPVRYTGATKGIMDMDEDCLYLNVY 240
            :|.|||:|...|.|.    |:.|.||| .|:|.:|...|.|.......|.|    .|||||||::
Mouse    50 IFKGIPFATAKTLEN----PQRHPGWQGTLKATNFKKRCLQATITQDNTYG----QEDCLYLNIW 106

  Fly   241 SPKTGAGVAQKYPVMVYIHGGEFIRGASN--------LFQGHILASFYDVVVVTLNYRLGALGFL 297
            .|:....|:...||||:|:||.|:.|:..        |:.|..:|:..:|:|||.|||:|.||||
Mouse   107 VPQGRKQVSHNLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFL 171

  Fly   298 STGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRV 362
            ||||.|.|||:|:.||.||:.||..||..|.||.::||:||..||.||..|..::|..:.::||.
Mouse   172 STGDANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRA 236

  Fly   363 IAQSGSALADWALIQDKYRAQNT---SRVLGQLLGCSIESSWKLVNCL-----RTGRSFYEL--G 417
            |:|||.||:.||:      .:|.   ::.:.:.:||..|.:.|:..||     |.....|:|  .
Mouse   237 ISQSGMALSPWAI------QKNPLFWAKTIAKKVGCPTEDTGKMAACLKITDPRALTLAYKLPVK 295

  Fly   418 NAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNR--NIQYMTGV 480
            ..|: |.|....:.||:|.:| :|.|                 |..|     :|.  :|.|:.|:
Mouse   296 KQEY-PVVHYLAFIPVIDGDF-IPDD-----------------PINL-----YNNTADIDYIAGI 336

  Fly   481 TTQEAAFFVAQNESLSPYYELDGRFFD---QKIREHVFRYNYTL-NPNGVYEAIK------YIYT 535
            ...:...|..          :|....|   |.:.|..|   |.| :.:.|.:.:|      .|||
Mouse   337 NNMDGHLFAT----------IDVPAVDKTKQTVTEEDF---YRLVSGHTVAKGLKGAQATFDIYT 388

  Fly   536 -FWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQ------KVPVYMYVLNTTVEALNLPQ 593
             .|....:...::...:...:|:.:..|.:    :.|.|      ....|.|:.:........|:
Mouse   389 ESWAQDPSQENMKKTVVAFETDVLFLIPTE----IALAQHKAHAKSAKTYSYLFSHPSRMPIYPK 449

  Fly   594 WRKYPHDIERYFLTGAPF-MDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPT-PQQ 656
            |....|..:..::.|.|| ....:.|:            ||.:|...:..:|||||.|:|. ...
Mouse   450 WMGADHADDLQYVFGKPFATPLGYRPQ------------DRAVSKAMIAYWTNFARSGDPNMGNS 502

  Fly   657 VLGMHFQRAYQGEIRYLNINTTYNSSILLNY-RQTECAFWT---QYLPTVIGVLVPTYPPTTEYW 717
            .:..|:.........||:|..|..|:.:..: |:....||.   :.||||.|......||..:..
Mouse   503 PVPTHWYPYTLENGNYLDITKTITSASMKEHLREKFLKFWAVTFEVLPTVTGDQDTLTPPEDDSE 567

  Fly   718 WEPKEP 723
            ..|..|
Mouse   568 VAPDPP 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	161/558 (29%)
		PRK13335	818..>918	CDD:139494
Cel	NP_034015.1	COesterase	26..542	CDD:395084	161/558 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	553..599		5/21 (24%)
		4 X 11 AA tandem repeats, O-glycosylated region	559..588		4/15 (27%)