DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gli and Nlgn1

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_038957495.1	Gene:	Nlgn1 / 116647	RGDID:	621117	Length:	863	Species:	Rattus norvegicus

Alignment Length:	842	Identity:	229/842 - (27%)
Similarity:	349/842 - (41%)	Gaps:	200/842 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 QRRDSLTLERDVFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPT 188
            |:.|.:    |..||||:|:::|.|..:.                :.::|....|||:|||.|||
  Rat    46 QKLDDV----DPLVTTNFGKIRGIKKELN----------------NEILGPVIQFLGVPYAAPPT 90

  Fly   189 FEGRFKPPRVHRGW-QLLQAVDFGPACPQ------------PVRYTG----ATKGIMDMDEDCLY 236
            .|.||:||.....| .:..|..|.|.|||            ||.:|.    .:..:.|..|||||
  Rat    91 GEHRFQPPEPPSPWSDIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLY 155

  Fly   237 LNVYSP-------------KTGAGVAQK-----------------------------YPVMVYIH 259
            ||:|.|             |.|..:.:|                             .|||||||
  Rat   156 LNIYVPTEDVKRISKECARKPGKKICRKGGPLTKTQTDDLGDNDRAEDEDIRDSGGPKPVMVYIH 220

  Fly   260 GGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNI 324
            ||.::.|..||:.|.:|||:.:|:|:|:|||||.||||||||:.:.||||:||...||||..:||
  Rat   221 GGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENI 285

  Fly   325 EFFNGDRNSITLFGPGAGGASAGLLMV---------APQTRNIVRRVIAQSGSALADWALIQDKY 380
            .||.||...||:||.||||:...||.:         :..|:.:.:|.|||||:||:.||:   .:
  Rat   286 GFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAV---SF 347

  Fly   381 RAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDW 445
            :....:|:|...:||::..:.:||.||:. :.:.||.:.:..|......:|||:|.: .:|.|
  Rat   348 QPAKYARILATKVGCNVSDTVELVECLQK-KPYKELVDQDVQPARYHIAFGPVIDGD-VIPDD-- 408

  Fly   446 YEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVA------QNESLSPYYELDGR 504
                           |:.|:..|:| .|...|.||...|...||.      ...|.|.:......
  Rat   409 ---------------PQILMEQGEF-LNYDIMLGVNQGEGLKFVENIVDSDDGVSASDFDFAVSN 457

  Fly   505 FFDQKIREHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKL 569
            |.|.       .|.|....:.:.|.||::||.|.|.:|....|...:.:.:|..:.||......|
  Rat   458 FVDN-------LYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADL 515

  Fly   570 MLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPFM-DTEFFPKKEHLQRNMWTDNDR 633
            ......|.|.|......:...:|.|....|..|..::.|.|.: .||.||..       ::.||.
  Rat   516 HSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCN-------FSKNDV 573

  Fly   634 NMSHFFMQTYTNFARYGN---PTPQQVLGMH----------FQRAYQGEIRYLNINTTYNSSILL 685
            .:|...|..:||||:.|:   |.||....:|          :.|..|.:..||:|.  ....:..
  Rat   574 MLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIG--LKPRVKE 636

  Fly   686 NYRQTECAFWTQYLPTVIGV-------LVPTYPPTTEYWWEP----KEPLQIAF----------- 728
            :||..:...|.:.:|.:..:       ...|..|:|:....|    ..|:..||
  Rat   637 HYRANKVNLWLELVPHLHNLNDISQYTSTTTKVPSTDITLRPTRKNSTPVTSAFPTAKQDDPKQQ 701

  Fly   729 --------------WSMSVA----CFFLIVLVVICCIMWRNAKRQSD---RFYDEDVFINGEGLE 772
                          .|:::|    ..||.:| ....:.::..||:.|   |...:....|.....
  Rat   702 PSPFSVDQRDYSTELSVTIAVGASLLFLNIL-AFAALYYKKDKRRHDVHRRCSPQRTTTNDLTHA 765

  Fly   773 PEQDTRGVDNAHMVTNHHALRSRDNIYEYR-----DSPSTKTLASKAHTDTTSLRSPSSLAM 829
            ||::...:...|...:|..    ::|:.:.     ..|...|||.:...|...|.:|:::.|
  Rat   766 PEEEIMSLQMKHTDLDHEC----ESIHPHEVVLRTACPPDYTLAMRRSPDDVPLMTPNTITM 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	195/648 (30%)
Nlgn1	XP_038957495.1	COesterase	52..646	CDD:395084	195/648 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020