Protein Alignment Gli and CEL

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_001798.3
• Gene: CEL / 1056
• HGNCID: 1848
• Length: 753
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 167/602 - (27%)
• Similarity: 258/602 - (42%)
• Gaps: 110/602 - (18%)

  Fly   168 VDRVMG----ECSVFLGIPYALPPTFEGRFKPPRVHRGWQ-LLQAVDFGPACPQPVRYTGATKGI 227
            |::.:|    ...:|.|||:|.|..   ..:.|:.|.||| .|:|.:|...|.|......:|.|
Human    36 VNKKLGLLGDSVDIFKGIPFAAPTK---ALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYG- 96

  Fly   228 MDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIRGASN--------LFQGHILASFYDVVV 284
               ||||||||::.|:....|::..|||::|:||.|:.|:.:        |:.|..:|:..:|:|
Human    97 ---DEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIV 158

  Fly   285 VTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLL 349
            ||.|||:|.||||||||.|.|||||:.||.||:.||..||..|.||.|:|||||..|||||..|.
Human   159 VTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQ 223

  Fly   350 MVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNT---SRVLGQLLGCSIESSWKLVNCLR--- 408
            .::|..:.::||.|:|||.||:.|.:      .:|.   ::.:.:.:||.:..:.::..||:
Human   224 TLSPYNKGLIRRAISQSGVALSPWVI------QKNPLFWAKKVAEKVGCPVGDAARMAQCLKVTD 282

  Fly   409 ----TGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGD-----------DWYEGWREKDWRFLT 458
                |......|...|: |.:....:.||:|.:| :|.|           |:..|....|.....
Human   283 PRALTLAYKVPLAGLEY-PMLHYVGFVPVIDGDF-IPADPINLYANAADIDYIAGTNNMDGHIFA 345

  Fly   459 QTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELDGRFFDQKIREHVFRYNYTLNP 523
            ......|..|  |:.:       |:|            .:|:|            |..:..|...
Human   346 SIDMPAINKG--NKKV-------TEE------------DFYKL------------VSEFTITKGL 377

  Fly   524 NGVYEAIKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQ------KVPVYMYVL 582
            .|...........|....:....:...::..:|:.:..|.:    :.|.|      ....|.|:.
Human   378 RGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTE----IALAQHRANAKSAKTYAYLF 438

  Fly   583 NTTVEALNLPQWRKYPHDIERYFLTGAPF-MDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNF 646
            :........|:|....|..:..::.|.|| ..|.:.|:            ||.:|...:..:|||
Human   439 SHPSRMPVYPKWVGADHADDIQYVFGKPFATPTGYRPQ------------DRTVSKAMIAYWTNF 491

  Fly   647 ARYGNPT-PQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTE-CAFWT-QY--LPTVIGVL 706
            |:.|:|. ....:..|::........||.|.....||.:....:|. ..:|| .|  ||||....
Human   492 AKTGDPNMGDSAVPTHWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWTLTYLALPTVTDQE 556

  Fly   707 VPTYPPTTEYWWEPKEP 723
            ....|||.:....|..|
Human   557 ATPVPPTGDSEATPVPP 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	155/569 (27%)
CEL	NP_001798.3	Heparin-binding	21..121		31/91 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..753		5/19 (26%)
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745		5/15 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870