Protein Alignment Gli and Ces2

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_001258232.1
• Gene: Ces2 / 100910144
• RGDID: 6504334
• Length: 561
• Species: Rattus norvegicus
• Alignment Length: 614
• Identity: 172/614 - (28%)
• Similarity: 262/614 - (42%)
• Gaps: 119/614 - (19%)

  Fly   120 LQGKQRRDSLTLERDVFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYA 184
            :||:...:|..:.     ||:.|||||...::.|                 .......|||||:|
  Rat    24 VQGQDSPESSPIR-----TTHTGQVQGKLDHVKD-----------------TKAGVHTFLGIPFA 66

  Fly   185 LPPTFEGRFKPPRVHRGWQLLQAVDFGPA-CPQPVRYTGATKGIMD---------MDEDCLYLNV 239
            .||....||.||.....|..::.....|| |.|.:...... |::|         |.||||||||
  Rat    67 KPPVGPLRFAPPEPPEPWSGVRDATSQPAMCLQNLDILDEV-GLLDMKMILSSISMSEDCLYLNV 130

  Fly   240 YSPKTGAGVAQKYPVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENS 304
            |:| ..|......||||:||||..:.|.::::.|.:|....|:||||:.||||.|||.|||||::
  Rat   131 YAP-AHAREGSNLPVMVWIHGGALVVGMASMYDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDEHA 194

  Fly   305 PGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSA 369
            .||:|.|||..|||||..||..|.|:.|.:|:||..|||.|....:::|.::.:....|.:||.|
  Rat   195 RGNWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGESAGGTSVSSHVISPMSQGLFHGAIMESGVA 259

  Fly   370 LADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLR--TGRSFYELGNAEFSPQVGSFPWGP 432
            |.. .||.:  .::..|..:.:|.||....|..||.|||  :|.....:...        |...|
  Rat   260 LLP-DLISE--TSETVSTTVAKLSGCEAMDSEALVRCLRAKSGAEILVINKV--------FKMIP 313

  Fly   433 VLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSP 497
            .:                 .|..||.:.|:.|:.:..|: .:..:.||.|.|....:......:
  Rat   314 AV-----------------VDGEFLPRHPKELLASEDFH-PVPSIIGVNTDEYCCTIPMVMGTA- 359

  Fly   498 YYELDGRFFDQKIREHVFRYNYTLNPNGVYEAIK---------------YIYTFWPDPNNNTIIR 547
                      |.|:|        |:...:...:|               .:..:..:.:::..::
  Rat   360 ----------QIIKE--------LSRENLQAVLKDTAAQMMLPPECGDLLMEEYMGNTDDSQTLQ 406

  Fly   548 DQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKY---PHDIERYFLTGA 609
            .||..|:.|..:..|..|:.... ....|||.|      |..:.|.:.|.   || ::.......
  Rat   407 IQYTEMMGDFLFVIPALQVAHFQ-RSHAPVYFY------EFQHAPSYFKNVRPPH-VKADHADEV 463

  Fly   610 PFMDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLN 674
            ||:...||..    .:..:|:.:|.:|...|:.:.||||.|||..:   |:.:..|...:.:||.
  Rat   464 PFVFGSFFSG----MKLDFTEEERLLSRRMMKYWANFARQGNPNSE---GLPYWPALDHDEQYLQ 521

  Fly   675 INTTYNSSILLNYRQTECAFWTQYLPTVI 703
            ::|.......|..|:.:  |||:.||..|
  Rat   522 LDTHPAVDRALKARRLQ--FWTKTLPQKI 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	163/590 (28%)
Ces2	NP_001258232.1	COesterase	31..540	CDD:278561	164/597 (27%)
		Aes	<130..>233	CDD:223730	52/103 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336211
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830