Protein Alignment Gli and nlgn3

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: XP_012823589.1
• Gene: nlgn3 / 100329188
• XenbaseID: XB-GENE-977261
• Length: 843
• Species: Xenopus tropicalis
• Alignment Length: 844
• Identity: 234/844 - (27%)
• Similarity: 347/844 - (41%)
• Gaps: 216/844 - (25%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |.|:||:::|.:|     |.|           ..::|....:||:|||.||..|.||.||.....
 Frog    38 VNTHYGKLRGTRV-----PLP-----------SEILGPVDQYLGVPYAAPPVGEKRFLPPEPPPS 86

  Fly   202 WQ-LLQAVDFGPACPQ-----------PVRYTG----ATKGIMDMDEDCLYLNVYSP-------- 242
            |. :..|..|.|.|||           ||.:|.    .|..:.:..|||||||:|.|
 Frog    87 WSGIRNATHFSPVCPQNIQNAVPDIMMPVWFTSNLDTVTGYLQEQSEDCLYLNIYVPTEDVKRIS 151

  Fly   243 ------------KTGAGVAQKY---------------------PVMVYIHGGEFIRGASNLFQGH 274
                        :.|...|:|.                     |||||||||.::.|:.|:..|.
 Frog   152 KECVRKPNKKICRKGGPSAKKQGEELSDNDEDEEGDIRDTGAKPVMVYIHGGSYMEGSGNMIDGS 216

  Fly   275 ILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGP 339
            :|||:.:|||:|||||:|.||||||||:.:.||||:|||..|||||.:|:.||.||.:.||:||.
 Frog   217 VLASYGNVVVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENVAFFGGDPHRITVFGS 281

  Fly   340 GAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLV 404
            |.|.:...||.::..:..:.:|.|.||||||:.||:   .|:....:|:|.:.:||::..:..:|
 Frog   282 GIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAV---NYQPVKYTRLLAEKVGCNVLDTVDMV 343

  Fly   405 NCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGK 469
            :|||. :|..||...:..|......:|||:|.: .:|.|                 ||.|:..|:
 Frog   344 DCLRQ-KSAKELVEQDIQPARYHVAFGPVIDGD-VIPDD-----------------PEILMEQGE 389

  Fly   470 FNRNIQYMTGVTTQEAAFFVAQNESLSPYYE-LDGRFFDQKIREHVFR-YNYTLNPNGVYEAIKY 532
            | .|...|.||...|...||   |::....: :.|..||..:...|.. |.|....:.:.|.||:
 Frog   390 F-LNYDIMLGVNQGEGLKFV---ENVVDAEDGVSGSDFDYSVSNFVDNLYGYPEGKDTLRETIKF 450

  Fly   533 IYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKY 597
            :||.|.|.:|....|...:.:.:|..:..|......|......|.|.|......::|..|.|...
 Frog   451 MYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWADA 515

  Fly   598 PHDIERYFLTGAPFM-DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVL 658
            .|..|..::.|.|.: .|:.||..       ::.||..:|...|..:||||:.|:   |.||...
 Frog   516 AHGDEVPYVFGVPMVGPTDLFPCN-------FSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTK 573

  Fly   659 GMHFQRAYQGEIR----------YLNINTTYNSSILLNYRQTECAFWTQYLPTVIGV-------- 705
            .:|.:.....|:.          ||:|.  ....:..:||.|:.|||...:|.:..:
 Frog   574 FIHTKANRFEEVAWSKYNPRDQLYLHIG--LKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTS 636

  Fly   706 LVPTYPP--TTE--------YWWEPKEP-------LQIAFW----------------------SM 731
            .....||  ||:        ..|:.|.|       ..:|.|                      |:
 Frog   637 TTTKVPPSDTTQNSHITRRPKVWDTKRPGVSPTFNGPVAKWDPELDPVDPVVIQDPRDYSTELSV 701

  Fly   732 SVA----CFFLIVLVVICCIMWRNAKRQSDRFYDEDVFINGEGLEPEQDTRGVDNAHM------- 785
            ::|    ..||.|| ....:.:||.||:.|         ......|::.....|.||.
 Frog   702 TIAVGASLLFLNVL-AFAALYYRNDKRRQD---------TQRQPSPQRPAVTRDPAHSPVPPEEL 756

  Fly   786 ----------------VTNHHALRSRDNIYEYRDSPSTKTLASKAHTDTTSLRSPSSLAMTQKS 833
                            |:.|..|| ...:.:|       ||..:...|...|.:|:::.|...|
 Frog   757 NSLQINAGHPECEGGGVSGHDNLR-LPTLPDY-------TLTLRRSPDDIPLMTPNTITMIPNS 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	195/630 (31%)
		PRK13335	818..>918	CDD:139494	4/16 (25%)
nlgn3	XP_012823589.1	COesterase	35..618	CDD:395084	195/630 (31%)