DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gli and nlgn1

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_017949302.2	Gene:	nlgn1 / 100329186	XenbaseID:	XB-GENE-6041753	Length:	859	Species:	Xenopus tropicalis

Alignment Length:	828	Identity:	233/828 - (28%)
Similarity:	351/828 - (42%)	Gaps:	178/828 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 QRRDSLTLERDVFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPT 188
            |:.|.:    |..|.|.||:|:|||..:.                :.::|....|||:|||.||.
Frog    46 QKLDDV----DPVVLTTYGKVRGFKKELN----------------NEILGPVVQFLGVPYAAPPI 90

  Fly   189 FEGRFKPPRVHRGW-QLLQAVDFGPACPQ------------PVRYTG----ATKGIMDMDEDCLY 236
            .|.||:||.....| .:..:..|.|.|||            ||.:|.    .:..:.|..|||||
Frog    91 GERRFQPPEPPTMWGDIKNSTQFAPVCPQNIVGGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLY 155

  Fly   237 LNVYSP-------------KTGAGVAQK-----------------------------YPVMVYIH 259
            ||:|.|             |.|..:.:|                             .|||||||
Frog   156 LNIYVPTEDVKRISKECARKPGKKICRKEGPLTKKQTDDLGDNEGAEDEDIRDSGGPKPVMVYIH 220

  Fly   260 GGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNI 324
            ||.::.|..|:|.|.:|||:.:|:|:|:|||||.||||||||:.|.||||:||...||||..:||
Frog   221 GGSYMEGTGNVFDGSVLASYGNVIVITVNYRLGVLGFLSTGDQASKGNYGLLDLIQALRWTSENI 285

  Fly   325 EFFNGDRNSITLFGPGAGGASAGLLMV---------APQTRNIVRRVIAQSGSALADWALIQDKY 380
            .||.||...||:||.|||.:...||.:         :..|:.:.:|.|||||:||:.||:   .:
Frog   286 GFFGGDPLRITVFGSGAGASCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAV---SF 347

  Fly   381 RAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDW 445
            :....:|:|...:||::..|.:||.||:. :.:.||.:.:..|......:|||:|.: .:|.|
Frog   348 QPAKYARILATKVGCNMSDSGELVECLQK-KPYRELVDQDIQPVRYHIAFGPVIDGD-VIPDD-- 408

  Fly   446 YEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYE-LDGRFFDQK 509
                           |:.|:..|:| .|...|.||...|...||   ||...:.: :....||..
Frog   409 ---------------PQVLMEQGEF-LNYDIMLGVNQGEGLKFV---ESTVDHEDGVSSSDFDFA 454

  Fly   510 IREHVFR-YNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQ 573
            :...|.. |.||...:.:.|.||::||.|.|.||....|...:.:.:|..:.||......|....
Frog   455 VSNFVDNLYGYTEGKDILRETIKFMYTDWADRNNPETRRKTLLALFTDHQWVAPAVATADLHSNF 519

  Fly   574 KVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPFM-DTEFFPKKEHLQRNMWTDNDRNMSH 637
            ..|.|.|......:...:|.|....|..|..::.|.|.: .||.||..       ::.||..:|.
Frog   520 GSPTYFYAFYHHCQTDQVPAWADASHGDEIPYVFGIPMIGPTELFPCN-------FSKNDVMLSA 577

  Fly   638 FFMQTYTNFARYGN---PTPQQVLGMH----------FQRAYQGEIRYLNINTTYNSSILLNYRQ 689
            ..|..:||||:.|:   |.||....:|          :.|..|.:..||:|.  ....:..:||.
Frog   578 VVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIG--LKPRVKEHYRA 640

  Fly   690 TECAFWTQYLPT--VIGVLVPTYPPTTEYWWEP----KEPLQIAFWSMS---------------- 732
            |:...|.:.:|.  |:..|..|..|:|:...:|    ..|:..||.::|
Frog   641 TKVNLWLELVPRLHVMNDLTTTKGPSTDITSKPTGSNTVPVTSAFPTVSEDNFKQKPSSISLERD 705

  Fly   733 ------------VACFFLIVLVVICCIMWRNAKRQSD---RFYDEDVFINGEGLEPEQDTRGVDN 782
                        .:..||.:| ....:.::..||:.|   |...:....|......|::...:..
Frog   706 YSTELSVTIAVGASLLFLNIL-AFAALYYKKDKRRHDVHRRCSPQRTTANDIAHAQEEEIMSLQM 769

  Fly   783 AHMVTNHHALRSRDNIYEYRDS-PSTKTLASKAHTDTTSLRSPSSLAM 829
            .|...:|.......:....|:: |...|||.:...|...|.:|:::.|
Frog   770 KHTDLDHECESIHPHEVVLRNACPPDYTLAMRRSPDDIPLMTPNTITM 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	199/644 (31%)
nlgn1	XP_017949302.2	COesterase	52..646	CDD:395084	199/644 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920