DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gli and nlgn4xb

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_001159809.1	Gene:	nlgn4xb / 100147967	ZFINID:	ZDB-GENE-100309-1	Length:	795	Species:	Danio rerio

Alignment Length:	897	Identity:	239/897 - (26%)
Similarity:	369/897 - (41%)	Gaps:	231/897 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 VFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVH 199
            :.||||||:::|.:|                :....::|....|||:|||:.||.|.||:.|...
Zfish    23 ITVTTNYGKLRGLRV----------------ALPSEILGPVEQFLGVPYAMAPTGERRFQAPEPP 71

  Fly   200 RGWQ-LLQAVDFGPACPQ------------PVRYTG-----ATKGIMDMDEDCLYLNVYSP---- 242
            ..|. :..|..|.|.|||            ||.:|.     ||. :.|..|||||||:|.|
Zfish    72 LSWPGIRNATQFAPVCPQFLEDRLLLTDMLPVWFTANLDTVATY-VHDQSEDCLYLNIYVPTEEE 135

  Fly   243 -KTGAGVAQKYPVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDENSPG 306
             :..||:.   |||||||||.::.|..|:..|.:|||:.:|:|||:|||||.||||||||:.:.|
Zfish   136 TQDDAGLK---PVMVYIHGGSYVEGTGNMIDGSVLASYGNVIVVTVNYRLGVLGFLSTGDQAAKG 197

  Fly   307 NYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALA 371
            |||:|||..|||||.:||:.|:||...:|:||.|||.:...||.::..:.::.::.|..||:||:
Zfish   198 NYGLLDQIQALRWVKENIQSFSGDPERVTIFGSGAGASCVSLLTLSHYSEDLFQKAIIHSGTALS 262

  Fly   372 DWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFPWGPVLDH 436
            .||:   .|:....:|:|.:.:||:.:.:.:|:.||:: :::.||.....:|......:|||:|.
Zfish   263 SWAV---NYQPAKYTRLLAEKVGCNEDDTLELIECLQS-KNYKELIEQNITPAKYHIAFGPVIDG 323

  Fly   437 NFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFV-----AQNESLS 496
            : .:|.|                 |:.|:..|:| .|...|.||...|...||     :::...|
Zfish   324 D-VIPDD-----------------PQILMEQGEF-LNYDIMLGVNQGEGYKFVDGILDSEDRVTS 369

  Fly   497 PYYELDGRFFDQKIREHVFRYNYTLNPNG---VYEAIKYIYTFWPDPNNNTIIRDQYINMLSDLY 558
            ..:|    |...:..:|::.|     |.|   :.|.||::||.|.|..|..:.|...:.:.:|..
Zfish   370 NDFE----FAISEFVDHLYGY-----PEGKDTLRETIKFMYTDWADRENPEMRRKTLVALFTDHQ 425

  Fly   559 YRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPFM-DTEFFPKKEH 622
            :.||......|..:...|.|.|......::...|.|....|..|..::.|.|.: .|:.|
Zfish   426 WVAPAVATADLHAQYGSPTYFYAFYHHCQSDMKPAWADSSHGDELPYVFGIPMIGPTDLF----- 485

  Fly   623 LQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVLGMHFQRAYQGEIRYLNINTTYNSSIL 684
              ...::.||..:|...|..:||||:.|:   |.||....:|.:.....|:.:    :.||....
Zfish   486 --NCNFSKNDIMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAW----SKYNPKDQ 544

  Fly   685 L------------NYRQTECAFWTQYLPTV--IGVLVPTYPPTTEYWWEPKEPLQIAFWSMSVAC 735
            |            :||.|:.|||.:.:|.:  |..|......||:.  .|::....::
Zfish   545 LYLHIGLKPRVRDHYRATKIAFWLELVPHLHNINELFQYVSSTTKI--PPQDTTPFSY------- 600

  Fly   736 FFLIVLVVICCIMWRNAKRQSDRFYDEDVFINGEGLEPEQDTRGVDNAHMVTNHHALRSRDNIYE 800
                            .||.|::.:..                        |..|......|..:
Zfish   601 ----------------TKRLSNKLFPS------------------------TTRHPPAPPANTKQ 625

  Fly   801 YRDSPSTKTLASKAHTDTTSLRSPSSLAMTQKSSSQASLKSGISLKETN------------GHLV 853
            ..|...|     ..|.|.|.:..    |....:....::..|.||...|            .|.:
Zfish   626 MSDQQKT-----SEHADGTVIIE----ARDYSTELSVTIAVGASLLFLNILAFAALYYKKDKHRL 681

  Fly   854 KQSERAATPRSQQNGSTAKVASPPVEEKRLLQ--------------------------------- 885
            :.|.|.:.||:..|    .:...|.||...||
Zfish   682 ESSRRLSPPRNHAN----DIPRVPSEELMSLQMKQMDHDHDCDSLQGHDMIRLTCPPDYALTLRR 742

  Fly   886 -----PLSST------PVTQLQAEPAKRVPTAASVSGSSRSTTPVPSARSTT 926
                 ||.:|      |.:....:||...|..| ...|:.|:|.:|...|||
Zfish   743 SPDDVPLMTTNAISMIPTSFSGMQPAYHTPFNA-FGNSTPSSTGLPHGHSTT 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	189/606 (31%)
nlgn4xb	NP_001159809.1	COesterase	17..567	CDD:278561	189/606 (31%)
nlgn4xb	NP_001159809.1	Aes	70..>243	CDD:223730	81/176 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020