Protein Alignment Gli and nlgn2b

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_001159808.1
• Gene: nlgn2b / 100002407
• ZFINID: ZDB-GENE-090918-3
• Length: 860
• Species: Danio rerio
• Alignment Length: 906
• Identity: 257/906 - (28%)
• Similarity: 379/906 - (41%)
• Gaps: 184/906 - (20%)

  Fly   120 LQGKQRRDSLTLERDVFVTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYA 184
            |...||.| ||..:...|||.||:::|.:..:.                :.::|....:||:|||
Zfish    38 LSSCQRAD-LTTAKHPMVTTGYGKLRGVRKELN----------------NEILGPVEQYLGVPYA 85

  Fly   185 LPPTFEGRFKPPRVHRGWQ-LLQAVDFGPACPQ-----------PVRYT----GATKGIMDMDED 233
            .||..|.||:||.....|| :..|..|.|.|||           ||.:|    .|...:.:..||
Zfish    86 TPPVGERRFQPPEAPGSWQEIRNATQFAPVCPQNIHGVLPEIMLPVWFTDNLDAAAAYVQNQSED 150

  Fly   234 CLYLNVYSPKTGAGVAQKY-------------------PVMVYIHGGEFIRGASNLFQGHILASF 279
            |||||||.|.....:.:|:                   |||::||||.|:.|..|:|...:||::
Zfish   151 CLYLNVYVPTEDGPLTKKHDESSMNRPRDEDIRDRRKKPVMLFIHGGSFMEGTGNMFDASVLAAY 215

  Fly   280 YDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGA 344
            .:|:|||:|||||.|||||:||:::.||||:|||..||||:.:||..|.||...||:||.|||.:
Zfish   216 GNVIVVTMNYRLGVLGFLSSGDQSAKGNYGLLDQIQALRWLNENIGHFGGDPERITIFGSGAGAS 280

  Fly   345 SAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRT 409
            ...||:::..:..:.:|.|||||||::.|::   .||....:::|.:.:|||...:..||:|||.
Zfish   281 CVNLLILSHHSEGLFQRAIAQSGSAISSWSV---NYRPLMYTKILAKKVGCSYSDTADLVDCLRR 342

  Fly   410 GRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNI 474
             :|:.||.:.:..|......:|||:|.: .:|.|                 ||.|::.|:| .|.
Zfish   343 -KSYRELVDQDVQPARYHIAFGPVVDGD-VVPDD-----------------PEILMQQGEF-LNY 387

  Fly   475 QYMTGVTTQEAAFFVAQNESLSPYYELDGRFFDQKIREHVFR-YNYTLNPNGVYEAIKYIYTFWP 538
            ..:.||...|...||..||...   .:....||..|...|.. |.|....:.:.|.||::||.|.
Zfish   388 DILLGVNQGEGLKFVDDNEGEE---GISAASFDYTISNFVDNLYGYPEGKDILRETIKFMYTDWA 449

  Fly   539 DPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIER 603
            |.:|..:.|...:.:.:|..:.||.....||..|.:.|||.|..:...:....|:|....|..|.
Zfish   450 DRDNGDMRRKTLLALFTDHQWVAPAVATAKLHAEFQSPVYFYTFHHHCQTEARPEWADAAHGDEI 514

  Fly   604 YFLTGAPFMD-TEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVLGMHFQR 664
            .::.|.|.:. ||.||..       ::.||..:|...|..:||||:.|:   |.||....:|.:.
Zfish   515 PYVFGVPMVGATELFPCN-------FSKNDIMLSAVVMTYWTNFAKTGDPNIPVPQDTKFIHTKP 572

  Fly   665 AYQGEI----------RYLNINTTYNSSILLNYRQTECAFWTQYLPTV--IGVLVPTY----PPT 713
            ....|:          :||:|.  ....|..|||..:.|||.:.:|.:  |...:|||    ||.
Zfish   573 NRFEEVIWTKFSSKDKQYLHIG--LKPRIRDNYRANKVAFWLELVPHLHTIHDEIPTYTTQLPPG 635

  Fly   714 TEYWWEPKEPLQIAFWSMSVACFFLIVLVVICCIMW---------RNAKRQSDRFYDEDVFINGE 769
            .     |..|                        .|         |:.:..:...|..|..:.|.
Zfish   636 A-----PHRP------------------------GWKGTAQSPGTRSTRHPTVSTYPPDPDLEGS 671

  Fly   770 GLEPEQ-----DTRGVDNAHMVT------------------------NHHALRSRD-NIYEYRDS 804
            ...||:     :||.......||                        .|..|:.|. .:...|.:
Zfish   672 EHPPERFPFPSNTRDYSTELSVTVAVGASLLFLNVLAFAALYYKRDKRHELLQRRHRRLSPQRGA 736

  Fly   805 -PSTKTLASKAHTDTTSLRSPSSLAMTQKSSSQASLKSGISLKETNGHLVKQSERAATPRSQQNG 868
             |....:....|.| .:|.....|...|....:..|..|..| .|.| |....|....|....:.
Zfish   737 VPGVGIVGGPPHND-LALSQEEELMSLQMKQQRVELDHGTPL-PTRG-LHGDLEPLRPPVCPPDY 798

  Fly   869 STAKVASP---PVEEKRLLQPLSSTPVTQLQAEPAKRVPTAASVSGSSRSTTPVPSARSTT 926
            :.|...:|   |:.....|..:.|| :|.:|...|......|....:..|...:|...|||
Zfish   799 TLALRRAPEDVPLMTANTLSMIPST-ITGMQPLHAFNTYPPAPAPSAGHSNNALPHQHSTT 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	196/607 (32%)
		PRK13335	818..>918	CDD:139494	22/102 (22%)
nlgn2b	NP_001159808.1	COesterase	52..611	CDD:395084	196/609 (32%)