Protein Alignment CycE and CCNE2

DIOPT Version :10

• Sequence 1: NP_001246037.1
• Gene: CycE / 34924
• FlyBaseID: FBgn0010382
• Length: 712
• Species: Drosophila melanogaster
• Sequence 2: NP_477097.1
• Gene: CCNE2 / 9134
• HGNCID: 1590
• Length: 404
• Species: Homo sapiens
• Alignment Length: 436
• Identity: 153/436 - (35%)
• Similarity: 212/436 - (48%)
• Gaps: 89/436 - (20%)

  Fly   264 SSTISPASSGCSQ------QQAVNGERTPGLPKHQEQIHHPVSDLMINMRTPMSPAVENGLRQC- 321
            |.|.||..:...|      .|.|...|.....|||.:|           |....|.:..|:..|
Human    17 SQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEI-----------RNCWPPVLSGGISPCI 70

  Fly   322 ------------------------------PLPALAWANAADVWRLMCHRDEQDSRLRSISMLEQ 356
                                          |||.|:|..:.:||..|..::.:....:...:|
Human    71 IIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKKESRYVHDKHFEVL-- 133

  Fly   357 HPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGITCLFVAAK 421
            |..|:|:||:||||||:||||||.|||||||||.|:.||::.....:.|..|||||||.||:|:|
Human   134 HSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASK 198

  Fly   422 VEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYMQLNVNNRTPASF 486
            :||||.||:.||||||||||:|.|||..|.|:|:||.|::.|:||..||.:::|::.....|
Human   199 LEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTIISWLNLFLQVDALKDAP--- 260

  Fly   487 SQIGRQKSAEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISHTFSREMALR 551
                         ..:.||:|...|:|.:||||||.|.:....:.|.:|.|||:.|..|.|:..:
Human   261 -------------KVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAALCHFTSIEVVKK 312

  Fly   552 CSGLDWQVIQPCARWMEPFFRVISQKAPYLQLNEQNEQVSNKFGLGLICPNIVTDDSHIIQTHTT 616
            .|||:|..|..|..||.||..|:...:| ::|....:              |..:|.|.|||||.
Human   313 ASGLEWDSISECVDWMVPFVNVVKSTSP-VKLKTFKK--------------IPMEDRHNIQTHTN 362

  Fly   617 TMDMYDEVLMAQDAAHAMRARIQASPATALRAPESLLTPPASSHKP 662
            .:.|.:||    :..:..|...|.||.    ....::|||.|:.||
Human   363 YLAMLEEV----NYINTFRKGGQLSPV----CNGGIMTPPKSTEKP 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	CYCLIN_CCNE_rpt1	327..459	CDD:410223	71/131 (54%)
		CYCLIN_CCNE_rpt2	463..576	CDD:410224	38/112 (34%)
CCNE2	NP_477097.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		7/26 (27%)
		CYCLIN_CCNE2_rpt1	100..236	CDD:410283	75/137 (55%)
		CYCLIN_CCNE2_rpt2	240..338	CDD:410285	38/113 (34%)