DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycE and CCNE2

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_477097.1	Gene:	CCNE2 / 9134	HGNCID:	1590	Length:	404	Species:	Homo sapiens

Alignment Length:	436	Identity:	153/436 - (35%)
Similarity:	212/436 - (48%)	Gaps:	89/436 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 SSTISPASSGCSQ------QQAVNGERTPGLPKHQEQIHHPVSDLMINMRTPMSPAVENGLRQC- 321
            |.|.||..:...|      .|.|...|.....|||.:|           |....|.:..|:..|
Human    17 SQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEI-----------RNCWPPVLSGGISPCI 70

  Fly   322 ------------------------------PLPALAWANAADVWRLMCHRDEQDSRLRSISMLEQ 356
                                          |||.|:|..:.:||..|..::.:....:...:|
Human    71 IIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKKESRYVHDKHFEVL-- 133

  Fly   357 HPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGITCLFVAAK 421
            |..|:|:||:||||||:||||||.|||||||||.|:.||::.....:.|..|||||||.||:|:|
Human   134 HSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDINKNMLQLIGITSLFIASK 198

  Fly   422 VEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYMQLNVNNRTPASF 486
            :||||.||:.||||||||||:|.|||..|.|:|:||.|::.|:||..||.:::|::.....|
Human   199 LEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCPVTIISWLNLFLQVDALKDAP--- 260

  Fly   487 SQIGRQKSAEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISHTFSREMALR 551
                         ..:.||:|...|:|.:||||||.|.:....:.|.:|.|||:.|..|.|:..:
Human   261 -------------KVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAALCHFTSIEVVKK 312

  Fly   552 CSGLDWQVIQPCARWMEPFFRVISQKAPYLQLNEQNEQVSNKFGLGLICPNIVTDDSHIIQTHTT 616
            .|||:|..|..|..||.||..|:...:| ::|....:              |..:|.|.|||||.
Human   313 ASGLEWDSISECVDWMVPFVNVVKSTSP-VKLKTFKK--------------IPMEDRHNIQTHTN 362

  Fly   617 TMDMYDEVLMAQDAAHAMRARIQASPATALRAPESLLTPPASSHKP 662
            .:.|.:||    :..:..|...|.||.    ....::|||.|:.||
Human   363 YLAMLEEV----NYINTFRKGGQLSPV----CNGGIMTPPKSTEKP 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	71/128 (55%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	23/53 (43%)
CCNE2	NP_477097.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		7/26 (27%)
		Cyclin_N	112..239	CDD:278560	71/128 (55%)
		Cyclin_C	241..361	CDD:281044	45/150 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146218
Domainoid	1	1.000	163	1.000	Domainoid score	I3966
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0002994
OrthoInspector	1	1.000	-	-		otm41165
orthoMCL	1	0.900	-	-		OOG6_105145
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2444
SonicParanoid	1	1.000	-	-		X2342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.740