DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycE and CCNE1

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001229.1	Gene:	CCNE1 / 898	HGNCID:	1589	Length:	410	Species:	Homo sapiens

Alignment Length:	457	Identity:	167/457 - (36%)
Similarity:	238/457 - (52%)	Gaps:	92/457 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 EDDDLLDDSCEDYS------------YDEDDEDDVEEEDDDVEIYSSTISPASSGCSQQ----QA 279
            |.|.:.:|...::|            :.:|.::::.:.|          ..|...|..|    .|
Human    12 ERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKID----------RTARDQCGSQPWDNNA 66

  Fly   280 VNGERTPGLPKHQEQIHHPVSDLMINMRTPMSPAVENGLRQCPLPALAWANAADVWRLMCHRDEQ 344
            |..:....:|...::     .|..:...:...|.:....|..|||.|:|||..:||::|.::::
Human    67 VCADPCSLIPTPDKE-----DDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEK- 125

  Fly   345 DSRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQ 409
             :.||....|||||.|||:|||||||||:||||||||||||||||.|:.|||:.....|.||.||
Human   126 -TYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQ 189

  Fly   410 LIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYM 474
            ||||:.||:|||:|||||||:.:|||||||||:..:||..|.::::||.|.:||:||..||.|||
Human   190 LIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYM 254

  Fly   475 QLNVNNRTPASFSQIGRQKSAEADD--AFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAA 537
            |:                  |..:|  ..:.||:....|:|.::|||||.|||....:.|.:|||
Human   255 QV------------------AYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAA 301

  Fly   538 AAISHTFSREMALRCSGLDWQVIQPCARWMEPFFRVI----SQKAPYLQLNEQNEQVSNKFGLGL 598
            :|:.|..|.|:..:.||..|..|:.|.:||.||..||    |.|..:.:
Human   302 SALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFR---------------- 350

  Fly   599 ICPNIVTDDSHIIQTHTTTMDMYDEVLMAQDAAHAMRARI----QASPATALRAPESLLTPPASS 659
               .:..:|:|.||||..::|:.|:       |.|.:|.:    :|||     .|..|||||.|.
Human   351 ---GVADEDAHNIQTHRDSLDLLDK-------ARAKKAMLSEQNRASP-----LPSGLLTPPQSG 400

  Fly   660 HK 661
            .|
Human   401 KK 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	78/128 (61%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	24/53 (45%)
CCNE1	NP_001229.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		4/17 (24%)
		Cyclin_N	115..242	CDD:306612	78/128 (61%)
		Cyclin_C	245..363	CDD:308564	47/154 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..410		12/30 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146266
Domainoid	1	1.000	163	1.000	Domainoid score	I3966
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H14452
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0002994
OrthoInspector	1	1.000	-	-		otm41165
orthoMCL	1	0.900	-	-		OOG6_105145
Panther	1	1.100	-	-	LDO	PTHR10177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2444
SonicParanoid	1	1.000	-	-		X2342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.740