Protein Alignment CycE and CCNE1

DIOPT Version :10

• Sequence 1: NP_001246037.1
• Gene: CycE / 34924
• FlyBaseID: FBgn0010382
• Length: 712
• Species: Drosophila melanogaster
• Sequence 2: NP_001229.1
• Gene: CCNE1 / 898
• HGNCID: 1589
• Length: 410
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 167/457 - (36%)
• Similarity: 238/457 - (52%)
• Gaps: 92/457 - (20%)

  Fly   231 EDDDLLDDSCEDYS------------YDEDDEDDVEEEDDDVEIYSSTISPASSGCSQQ----QA 279
            |.|.:.:|...::|            :.:|.::::.:.|          ..|...|..|    .|
Human    12 ERDTMKEDGGAEFSARSRKRKANVTVFLQDPDEEMAKID----------RTARDQCGSQPWDNNA 66

  Fly   280 VNGERTPGLPKHQEQIHHPVSDLMINMRTPMSPAVENGLRQCPLPALAWANAADVWRLMCHRDEQ 344
            |..:....:|...::     .|..:...:...|.:....|..|||.|:|||..:||::|.::::
Human    67 VCADPCSLIPTPDKE-----DDDRVYPNSTCKPRIIAPSRGSPLPVLSWANREEVWKIMLNKEK- 125

  Fly   345 DSRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQ 409
             :.||....|||||.|||:|||||||||:||||||||||||||||.|:.|||:.....|.||.||
Human   126 -TYLRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKTLLQ 189

  Fly   410 LIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYM 474
            ||||:.||:|||:|||||||:.:|||||||||:..:||..|.::::||.|.:||:||..||.|||
Human   190 LIGISSLFIAAKLEEIYPPKLHQFAYVTDGACSGDEILTMELMIMKALKWRLSPLTIVSWLNVYM 254

  Fly   475 QLNVNNRTPASFSQIGRQKSAEADD--AFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAA 537
            |:                  |..:|  ..:.||:....|:|.::|||||.|||....:.|.:|||
Human   255 QV------------------AYLNDLHEVLLPQYPQQIFIQIAELLDLCVLDVDCLEFPYGILAA 301

  Fly   538 AAISHTFSREMALRCSGLDWQVIQPCARWMEPFFRVI----SQKAPYLQLNEQNEQVSNKFGLGL 598
            :|:.|..|.|:..:.||..|..|:.|.:||.||..||    |.|..:.:
Human   302 SALYHFSSSELMQKVSGYQWCDIENCVKWMVPFAMVIRETGSSKLKHFR---------------- 350

  Fly   599 ICPNIVTDDSHIIQTHTTTMDMYDEVLMAQDAAHAMRARI----QASPATALRAPESLLTPPASS 659
               .:..:|:|.||||..::|:.|:       |.|.:|.:    :|||     .|..|||||.|.
Human   351 ---GVADEDAHNIQTHRDSLDLLDK-------ARAKKAMLSEQNRASP-----LPSGLLTPPQSG 400

  Fly   660 HK 661
            .|
Human   401 KK 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	CYCLIN_CCNE_rpt1	327..459	CDD:410223	80/131 (61%)
		CYCLIN_CCNE_rpt2	463..576	CDD:410224	42/118 (36%)
CCNE1	NP_001229.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		4/17 (24%)
		CYCLIN_CCNE1_rpt1	103..239	CDD:410282	84/137 (61%)
		CYCLIN_CCNE1_rpt2	243..356	CDD:410284	44/149 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..410		12/30 (40%)