Protein Alignment CycE and CCNA2

DIOPT Version :9

• Sequence 1: NP_001246037.1
• Gene: CycE / 34924
• FlyBaseID: FBgn0010382
• Length: 712
• Species: Drosophila melanogaster
• Sequence 2: NP_001228.2
• Gene: CCNA2 / 890
• HGNCID: 1578
• Length: 432
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 116/520 - (22%)
• Similarity: 199/520 - (38%)
• Gaps: 139/520 - (26%)

  Fly   126 LGFEPPSAKRQQRLPALYGSEQGNLSSVASSVYTSPVVSVDGQSTQELLSI-------------- 176
            ||...|....::...||...:|..|.....::.......|....|:..|::
Human     2 LGNSAPGPATREAGSALLALQQTALQEDQENINPEKAAPVQQPRTRAALAVLKSGNPRGLAQQQR 66

  Fly   177 ----RSSPAEDLSEAPHSPLPDSPDSPPSPDRGSKQTPVVVRY--AAEQVVTSTVVTQKTEDDDL 235
                |.:|.:||      |:.|...:.|.....|||....:..  |.::.......:||.|.:|.
Human    67 PKTRRVAPLKDL------PVNDEHVTVPPWKANSKQPAFTIHVDEAEKEAQKKPAESQKIEREDA 125

  Fly   236 LDDSCE-------------DYSYDEDDEDDVEEEDDDVEIYSSTISPASSGCSQQQAVNGERTPG 287
            |..:..             ||..|...|   .....|:.|......|.|        ||     .
Human   126 LAFNSAISLPGPRKPLVPLDYPMDGSFE---SPHTMDMSIILEDEKPVS--------VN-----E 174

  Fly   288 LPKHQEQIHHPVSDLMINMRTPMSPAVENGLRQCPLPALAWANAADVWRLMCHRDEQDSRLRSIS 352
            :|.:.|.||..:.::.:..:.                                         .:.
Human   175 VPDYHEDIHTYLREMEVKCKP-----------------------------------------KVG 198

  Fly   353 MLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGITCLF 417
            .:::.|.:...|||||:|||:||.|.|||..||.:|||:|:||:|. :..|.:..|||:|...:.
Human   199 YMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLS-SMSVLRGKLQLVGTAAML 262

  Fly   418 VAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYMQLNVNNRT 482
            :|:|.||||||::.||.|:||...|::.:|..|.::|:.|.:|::..|:..:|..|
Human   263 LASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQY--------- 318

  Fly   483 PASFSQIGRQKSAEADDAFIYPQFSGFEFVQTSQLL-DLCTLDVG-MANYSYSVLAAAAIS---H 542
                              |::.|.:..:....:..| :|..:|.. ...|..||:|.||..   :
Human   319 ------------------FLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALY 365

  Fly   543 TFS----REMALRCSGLDWQVIQPCARWMEPFFRVISQKAP-YLQLNEQNEQVSNKF-GLGLICP 601
            |.:    .|..:|.:|...:.::||...:...:    .||| :.|.:.:.:..::|: |:.|:.|
Human   366 TVTGQSWPESLIRKTGYTLESLKPCLMDLHQTY----LKAPQHAQQSIREKYKNSKYHGVSLLNP 426

  Fly   602  601
            Human   427  426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	48/128 (38%)
		Cyclin_C	<517..>571	CDD:281044	15/62 (24%)
CCNA2	NP_001228.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..45		2/18 (11%)
		Cyclin_N2	28..166	CDD:406812	25/146 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	55..75		1/19 (5%)
		CYCLIN_CCNA2_rpt1	175..305	CDD:410264	51/171 (30%)
		CYCLIN_CCNA2_rpt2	309..419	CDD:410267	25/140 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146268
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750