DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycE and CLB5

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_015445.1	Gene:	CLB5 / 856237	SGDID:	S000006324	Length:	435	Species:	Saccharomyces cerevisiae

Alignment Length:	351	Identity:	89/351 - (25%)
Similarity:	161/351 - (45%)	Gaps:	93/351 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 QSTQELLSIRSSPAEDLSEA-PHSPLPDSP--DSPPSPDR----GSKQTPVVVRYAAEQVVTSTV 225
            |:.:.|....||..:.:.:: |...|.|.|  ::|.|.::    |||...|........:|::
Yeast    34 QNKRALSKNDSSSKQQVQDSKPRRALTDVPVNNNPLSQNKRIVAGSKAAKVRREENIRPIVSA-- 96

  Fly   226 VTQKTEDDDLLDDSCEDYSYDEDDEDDVEEEDDDVEIYSSTISPASSGCSQQQAVNGERTPGLPK 290
             .||.:   :.:|..   :.::::|::.|.||||          |:|..::::.::.|....:..
Yeast    97 -VQKRQ---IYNDRT---AAEQEEEEEEEGEDDD----------AASIVNKKRRIDAEGVSEIVG 144

  Fly   291 HQEQIHHPVSDLMINMRTPMSPAVENGLRQCPLPALAWANAADVWRLMCHRDEQDSRLRSISMLE 355
            .|:..:....|                      .|:....:|:::..:..|:           ||
Yeast   145 WQDLDYVEKDD----------------------TAMVAEYSAEIFAFLYRRE-----------LE 176

  Fly   356 QHPG------------LQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHL 408
            ..|.            |:|.||.||:|||:||.|.::.:.||.:|:::.:||:| ..:||....|
Yeast   177 TLPSHNYLLDKTSKYYLRPSMRTILVDWLVEVHEKFQCYPETLFLSINLMDRFL-AKNKVTMNKL 240

  Fly   409 QLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVY 473
            ||:.:|.||:|||.||:..||:.|:||:||||.::.||.|.|..:|.:|:::|      ||
Yeast   241 QLLAVTSLFIAAKFEEVNLPKLAEYAYITDGAASKNDIKNAEMFMLTSLEFNI------GW---- 295

  Fly   474 MQLNVNNRTPASFSQIGRQKSAEADD 499
                   ..|.:|    .::.::|||
Yeast   296 -------PNPLNF----LRRISKADD 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	50/140 (36%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044
CLB5	NP_015445.1	COG5024	1..431	CDD:227357	89/351 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343528
Domainoid	1	1.000	101	1.000	Domainoid score	I1539
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840