DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycE and CLB2

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_015444.1	Gene:	CLB2 / 856236	SGDID:	S000006323	Length:	491	Species:	Saccharomyces cerevisiae

Alignment Length:	574	Identity:	124/574 - (21%)
Similarity:	218/574 - (37%)	Gaps:	200/574 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TRSVCSTSSTEPNGSIVTTAPSNGEVSSSIVVVVSSSSISSSSDSPIAILPHPDPIPSTSFSSAS 72
            |.:..:|||:....::...|.:|         |.:::...|::::|..          |:|.|..
Yeast     8 TENSQNTSSSRFLRNVQRLALNN---------VTNTTFQKSNANNPAL----------TNFKSTL 53

  Fly    73 QRSEEELPGTSAASRTDEMCSCDSQNLAASTAA-------TSNGNK--RKRRLSSDSNEDP---E 125
            ...::|      .||..:.   ..::::.||||       ..||.:  :...|....|:||   :
Yeast    54 NSVKKE------GSRIPQF---TRESVSRSTAAQEEKRTLKENGIQLPKNNLLDDKENQDPSSQQ 109

  Fly   126 LGFEPPSAKRQQRLPALYGSEQGNLSSVASSVYTSPVVSVDGQSTQEL---------------LS 175
            .|......:.:..|||....::.  ||....:...|:..| |.||:.:               |.
Yeast   110 FGALTSIKEGRAELPANISLQES--SSAKEIIQHDPLKGV-GSSTEVVHNSVENEKLHPARSQLQ 171

  Fly   176 IRSSPAEDLSEAPHSPLPDSPDSPPSPDRGSKQTPVVVRYAAEQVVTSTVVTQKTEDDDLLDDSC 240
            :|::.:|                   .|.|.|: |:           ||:|.|:......:   |
Yeast   172 VRNTESE-------------------TDSGKKR-PI-----------STIVEQELPKKFKV---C 202

  Fly   241 EDYSYDEDDEDDVEEED-DDVEIYSSTISPASSGCSQQQAVNGERTPGLPKHQEQIHHPVSDLMI 304
            ::...:|.:.:|::.|| :|..:.|..::.......|.:.:.      |||.::
Yeast   203 DENGKEEYEWEDLDAEDVNDPFMVSEYVNDIFEYLHQLEVIT------LPKKED----------- 250

  Fly   305 NMRTPMSPAVENGLRQCPLPALAWANAADVWRLMCHRDEQDSRLRSISMLEQHPGLQPRMRAILL 369
                                                             |.||..:. :.|.||:
Yeast   251 -------------------------------------------------LYQHRNIH-QNRDILV 265

  Fly   370 DWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFA 434
            :||:::...:.|..||.|||::.:||:|. ...||...|||:|.:|||:|:|.||:|.|.|..||
Yeast   266 NWLVKIHNKFGLLPETLYLAINIMDRFLG-KELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFA 329

  Fly   435 YVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYMQLNVNNRTPASFSQIGRQKSAEADD 499
            ..|||||||.:|...||.:|:.|                 :.|:|...|.:|    .::.::|||
Yeast   330 SETDGACTEDEIKEGEKFILKTL-----------------KFNLNYPNPMNF----LRRISKADD 373

  Fly   500 AFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSY-----SVLAAAAISHTFSREM 548
            ..|           .|:.|....|::.:.::.:     |:.||||:  ..||:|
Yeast   374 YDI-----------QSRTLAKFLLEISLVDFRFIGILPSLCAAAAM--FMSRKM 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	47/128 (37%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	10/37 (27%)
CLB2	NP_015444.1	COG5024	8..487	CDD:227357	124/574 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343520
Domainoid	1	1.000	101	1.000	Domainoid score	I1539
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840