DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycE and CYCA2;4

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_178153.1	Gene:	CYCA2;4 / 844377	AraportID:	AT1G80370	Length:	461	Species:	Arabidopsis thaliana

Alignment Length:	537	Identity:	123/537 - (22%)
Similarity:	203/537 - (37%)	Gaps:	166/537 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 VSSSSISSSSDSPIAILPHPDPIPSTSFSSASQRSEEELPGTSAASRTDEMCSCDSQNLAASTAA 105
            ||.:||      ||    |..|: :.:.:||.:.|.:.:..:..|:.|..    ..:.|.|.:..
plant     7 VSGNSI------PI----HGRPV-TRALASALRASSKLITSSEVAATTQN----QGRVLRAKSKR 56

  Fly   106 T------SNGNKRKRRLSSDSNEDPELGFEPPSAKRQQRLPAL-YGSEQGNLSSVASSVYTSPV- 162
            |      :|..|::..|...:|...|..:....:...:.:..: .|.:..:.|.||||..||.|
plant    57 TALDEKKANAPKKRAVLKDITNVTCENSYTSCFSVAVENIKQIKKGRQSSSSSKVASSSATSQVT 121

  Fly   163 ---VSVDGQSTQELLSIRSSPAEDLSEAPHSPL-PDSPDSPPSP----DR--GSKQTPVVVRYAA 217
               |.|...|....||:.:..:...:|..:|.: ..|..|||.|    :|  |...:|..|
plant   122 DAKVEVVSNSAGASLSVFTDTSLGTNETSYSIIAKPSSRSPPRPFGTVERSCGGASSPKFV---- 182

  Fly   218 EQVVTSTVVTQKTEDDDLLDDSCEDYSYDEDDEDDVEEEDDDVEIYSSTISPASSGCSQQQAVNG 282
                                              |::.:|.|..:           ||
plant   183 ----------------------------------DIDSDDKDPLL-----------CS------- 195

  Fly   283 ERTPGLPKHQEQIHHPVSDLMINMRTPMSPAVENGLRQCPLPALAWANAADVWRLMCHRDEQDSR 347
                        ::.|  |:..|:|..       .|::.|.|                 |..:..
plant   196 ------------LYAP--DIYYNLRVA-------ELKRRPFP-----------------DFMEKT 222

  Fly   348 LRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIG 412
            .|.::         ..||.||:|||:||.|.|.|..:|.||.|..:|.:|| .:.|::..|||:|
plant   223 QRDVT---------ETMRGILVDWLVEVSEEYTLVPDTLYLTVYLIDWFLH-GNYVERQRLQLLG 277

  Fly   413 ITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYMQLN 477
            |||:.:|:|.|||:.|:|.||.::||...|...:|..|..:|:...:.|
plant   278 ITCMLIASKYEEIHAPRIEEFCFITDNTYTRDQVLEMESQVLKHFSFQI---------------- 326

  Fly   478 VNNRTPASFSQIGR-QKSAEADDAFIYP-QFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAI 540
               .||.|.:.:.| .::|:..    :| |....||: .:.|.:|..:|.....:..|::||:|:
plant   327 ---YTPTSKTFLRRFLRAAQVS----FPNQSLEMEFL-ANYLTELTLMDYPFLKFLPSIIAASAV 383

  Fly   541 SHTFSREMALRCSGLDW 557
               |..:..|..|...|
plant   384 ---FLAKWTLNQSSHPW 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	44/128 (34%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	11/41 (27%)
CYCA2;4	NP_178153.1	CYCLIN_AtCycA_like_rpt1	190..325	CDD:410265	54/200 (27%)
CYCA2;4	NP_178153.1	CYCLIN_AtCycA-like_rpt2	329..443	CDD:410210	19/77 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920