DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycE and CYCA1;2

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_177863.2	Gene:	CYCA1;2 / 844075	AraportID:	AT1G77390	Length:	442	Species:	Arabidopsis thaliana

Alignment Length:	587	Identity:	135/587 - (22%)
Similarity:	219/587 - (37%)	Gaps:	180/587 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 VSSSSISSSSDSPIAILPHPDPIPS-TSFSSASQRS------EEELPGTSAASRTDEMCSCDSQN 98
            :||||.:.|.::||   |.|:...: ||......|.      ..:..|:...|.:..:.:| |..
plant     1 MSSSSRNLSQENPI---PRPNLAKTRTSLRDVGNRRAPLGDITNQKNGSRNPSPSSTLVNC-SNK 61

  Fly    99 LAASTAATSNGNKRKRRLS-SDSNEDPELGFEPPSAKRQQRLPALYGSEQGNLSSVASSVYTSPV 162
            :..|..|......|...|. .||...|:     |:||....:|.   .:...|.|..|.:.:||.
plant    62 IGQSKKAPKPALSRNWNLGILDSGLPPK-----PNAKSNIIVPY---EDTELLQSDDSLLCSSPA 118

  Fly   163 VSVDGQSTQELLSIRSSPAEDLSEAPHSPLPDSPDSPPSPDRGSKQTPVVVRYAAEQVVTSTVVT 227
            :|:|...||                          |.||.......|..||.|..|
plant   119 LSLDASPTQ--------------------------SDPSISTHDSLTNHVVDYMVE--------- 148

  Fly   228 QKTEDDDLLDDSCEDYSYDEDDEDDVEEEDDDVEIYSSTISP---ASSGCSQQQAVNGERTPGLP 289
             .|.||.           ::||:|::      |.|.|..:.|   ||..|...:
plant   149 -STTDDG-----------NDDDDDEI------VNIDSDLMDPQLCASFACDIYE----------- 184

  Fly   290 KHQEQIHHPVSDLMINMRTPMSPAVENGLRQCPLPALAWANAADVWRLMCHRDEQDSRLRSISML 354
                  |..||:  :|.|                |||.:                        |.
plant   185 ------HLRVSE--VNKR----------------PALDY------------------------ME 201

  Fly   355 EQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGITCLFVA 419
            .....:...||:||:|||:||.|.|:|..||.||||:|:|||| ..:.:.|.:|||:|:||:.:|
plant   202 RTQSSINASMRSILIDWLVEVAEEYRLSPETLYLAVNYVDRYL-TGNAINKQNLQLLGVTCMMIA 265

  Fly   420 AKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYMQLNVNNR-TP 483
            ||.||:..|::.:|.|:||......::|..|..:|..|.::::..|...:|..:::.....: .|
plant   266 AKYEEVCVPQVEDFCYITDNTYLRNELLEMESSVLNYLKFELTTPTAKCFLRRFLRAAQGRKEVP 330

  Fly   484 ASFSQIGRQKSAEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISHTFSREM 548
            :..|:                       .....|.:|..||..|..|:.|::||:|:   |..:.
plant   331 SLLSE-----------------------CLACYLTELSLLDYAMLRYAPSLVAASAV---FLAQY 369

  Fly   549 ALRCSGLDWQV------------IQPCARWMEPFFRVISQK--APYLQLNEQNEQVSNKFGLGLI 599
            .|..|...|..            ::.|   ::...::.::|  :..:.:.::..|...||....:
plant   370 TLHPSRKPWNATLEHYTSYRAKHMEAC---VKNLLQLCNEKLSSDVVAIRKKYSQHKYKFAAKKL 431

  Fly   600 CP 601
            ||
plant   432 CP 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	45/128 (35%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	15/65 (23%)
CYCA1;2	NP_177863.2	CYCLIN_AtCycA_like_rpt1	171..306	CDD:410265	57/194 (29%)
CYCA1;2	NP_177863.2	CYCLIN_AtCycA-like_rpt2	310..424	CDD:410210	21/142 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920