DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycE and CYCA1;1

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_175077.1	Gene:	CYCA1;1 / 841014	AraportID:	AT1G44110	Length:	460	Species:	Arabidopsis thaliana

Alignment Length:	570	Identity:	121/570 - (21%)
Similarity:	213/570 - (37%)	Gaps:	179/570 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 QNLAASTAATSNGNKRKRRLSSDSNEDPELGFEPPSAKRQ--------QRLPA-LYGSEQGNLSS 152
            ||..:|.::::..:..||:..|.|....:|  .|...|::        |::.: |..|:..:.|:
plant     6 QNRRSSFSSSTKSSLAKRQAPSSSENSVKL--MPAMTKKRAPLSNITNQKIASRLQNSDSVHCSN 68

  Fly   153 VASSVYTSPVVSVDGQSTQELL------SIRSSPAE-DLSEAPHSPLPDSPDSPPSPDRGSKQTP 210
            .::.:..:|.|.|:...:..|.      .:.|||:: |...........|.||..||.
plant    69 KSAKLKIAPSVCVNASFSSNLQQSIVPHKVASSPSKSDDGSVSMDETRSSSDSYKSPQ------- 126

  Fly   211 VVVRYAAEQVVTSTVVTQK--------TEDDDLLDDSCEDYSYDEDDEDDVEEEDDDVEIYSSTI 267
              |.|.....|::.|..::        |.:.:.:|:.|     ..|...|:::.|
plant   127 --VEYIENDDVSAVVSIERKALSNLFITPNSETIDNYC-----SRDVLSDMKKMD---------- 174

  Fly   268 SPASSGCSQQQAVNGERTPGLPKHQEQIHHPVSDLMINMRTPMSPAVENGLRQCPLPALAWANAA 332
                    :.|.||.:...|.|:                                   |....|.
plant   175 --------KNQIVNIDSNNGDPQ-----------------------------------LCATFAC 196

  Fly   333 DVWRLMCHRDEQDSRLR-SISMLEQ-HPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDR 395
            |:::   |....:::.| .:..:|: ...:...||.||:||||||.|.|:|..||.||.|:|:||
plant   197 DIYK---HLRASEAKKRPDVDYMERVQKDVNSSMRGILVDWLIEVSEEYRLVPETLYLTVNYIDR 258

  Fly   396 YLHVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWD 460
            ||. .:.:.:..|||:|:.|:.:|||.|||..|::.||.|:||....:.::|:.|..:|..|.::
plant   259 YLS-GNVISRQKLQLLGVACMMIAAKYEEICAPQVEEFCYITDNTYLKDEVLDMESDVLNYLKFE 322

  Fly   461 ISPITITGWL--------GVY----MQLNVNNRTPASFSQIGRQKSAEADDAFIYPQFSGFEFVQ 513
            ::..|...:|        ||:    |||.                                  ..
plant   323 MTAPTTKCFLRRFVRAAHGVHEAPLMQLE----------------------------------CM 353

  Fly   514 TSQLLDLCTLDVGMANYSYSVLAAAAISHTFSREMALRCSGLDWQVIQPCAR-WMEPFFRVISQK 577
            .:.:.:|..|:..|.::|.|::||:||.             |...::.|..| |..........|
plant   354 ANYIAELSLLEYTMLSHSPSLVAASAIF-------------LAKYILDPTRRPWNSTLQHYTQYK 405

  Fly   578 APYLQ--------------------LNEQNEQVSNKFGLGLICPNIVTDD 607
            |..|:                    :.|:..|...||.....||:::..:
plant   406 AMELRGCVKDLQRLCSTAHGSTLPAVREKYSQHKYKFVAKKFCPSVIPQE 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	48/130 (37%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	13/54 (24%)
CYCA1;1	NP_175077.1	CYCLIN_AtCycA_like_rpt1	187..322	CDD:410265	51/173 (29%)
CYCA1;1	NP_175077.1	CYCLIN_AtCycA-like_rpt2	326..440	CDD:410210	25/160 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920