DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycE and CYCB2;1

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_179353.1	Gene:	CYCB2;1 / 816269	AraportID:	AT2G17620	Length:	429	Species:	Arabidopsis thaliana

Alignment Length:	529	Identity:	114/529 - (21%)
Similarity:	192/529 - (36%)	Gaps:	160/529 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 SQNLAASTAATSNGNKRKRRLSSDSNEDPELGFEPPSAKRQQRLPALYGSEQGNLSSVASSVYTS 160
            :||||.:.......|||...||:...|:.                   |.::....|:..||..|
plant    44 NQNLAGARVYPCVVNKRGSLLSNKQEEEE-------------------GCQKKKFDSLRPSVTRS 89

  Fly   161 PVVSVDGQSTQELLSIRSSPAEDLSEAPHSPLPDSPDSPPSPDRGSKQTPVVVRYAAEQVVTSTV 225
               .|:.::.::|                     .|..|.:.|.|.     .:....|:......
plant    90 ---GVEEETNKKL---------------------KPSVPSANDFGD-----CIFIDEEEATLDLP 125

  Fly   226 VTQKTEDDDLLDDSCEDYSYDEDDEDDVEEEDDDVEIYSSTISPASSGCSQQQAVNGERTPGLPK 290
            :....|...:..|..|:.   |.::..|||...|:::..|..|.|:
plant   126 MPMSLEKPYIEADPMEEV---EMEDVTVEEPIVDIDVLDSKNSLAA------------------- 168

  Fly   291 HQEQIHHPVSDLMINMRTPMSPAVENGLRQCPLPALAWANAADVWRLMCHRDEQDSRLRSISMLE 355
                :.: |.||....||                         :.|..|         ..:..:.
plant   169 ----VEY-VQDLYAFYRT-------------------------MERFSC---------VPVDYMM 194

  Fly   356 QHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGITCLFVAA 420
            |...|..:|||||:||||||.:.:.|..||.:|.|:.:||:|. ...|.:..|||:|:..|.:|.
plant   195 QQIDLNEKMRAILIDWLIEVHDKFDLINETLFLTVNLIDRFLS-KQNVMRKKLQLVGLVALLLAC 258

  Fly   421 KVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYMQLNVNNRTPAS 485
            |.||:..|.:.:...::|.|.|..|:|..||.:|..|.::||                   .|..
plant   259 KYEEVSVPVVEDLVLISDKAYTRNDVLEMEKTMLSTLQFNIS-------------------LPTQ 304

  Fly   486 FSQIGR-QKSAEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAI--------- 540
            :..:.| .|:|:||...         .|..|.|::|..::..|..:..|:|||.::
plant   305 YPFLKRFLKAAQADKKC---------EVLASFLIELALVEYEMLRFPPSLLAATSVYTAQCTLDG 360

  Fly   541 SHTFSREMALRCSGLDWQVIQPCARWMEPFFRVIS--QKAPYLQLNEQNEQVS-NKFGLGLIC-- 600
            |..::......|...:.|::: |:|      :::|  |:|....|.....:.| :|||....|
plant   361 SRKWNSTCEFHCHYSEDQLME-CSR------KLVSLHQRAATGNLTGVYRKYSTSKFGYIAKCEA 418

  Fly   601 PNIVTDDSH 609
            .:.:..:||
plant   419 AHFLVSESH 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	43/128 (34%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	12/62 (19%)
CYCB2;1	NP_179353.1	Cyclin_N	174..300	CDD:278560	47/160 (29%)
CYCB2;1	NP_179353.1	Cyclin_C	302..419	CDD:281044	29/132 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920