DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycE and ccnf

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	XP_012825809.1	Gene:	ccnf / 496496	XenbaseID:	XB-GENE-963729	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	689	Identity:	139/689 - (20%)
Similarity:	226/689 - (32%)	Gaps:	232/689 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 VSVDGQSTQELLSIRSSPAEDLSEAPHS---PLPDSPDSPPSPDRGSKQTPVVVRYAAEQVVTST 224
            :|.||::  |:..:::|....|:|..:|   |.......||....||....||.....|:..|.|
Frog   117 LSDDGRA--EVNGLKASRFFSLTERLNSGADPFVWLFIRPPWSSSGSCCKAVVFDSLKEECGTVT 179

  Fly   225 ------------------VVTQKTEDDD-------LLDDS----CEDYSY---DEDDEDDVEEED 257
                              .|....||||       :|:.|    |...||   :...:..:.:..
Frog   180 SEEGATGALKGSIQYCLAKVLSLFEDDDKKREALGMLESSASHGCLHSSYLLWETKQKTALSDPG 244

  Fly   258 DDVEIYSSTISPASSGCSQQQAVNGERTPGLPKHQEQIHHPVSDLMINMRTPMSPAVENGLRQCP 322
            ..::.:......|:.||...| ::..:..|......|.....|:|:            |.:.|..
Frog   245 RYLQSFRQLRDYAARGCWDAQ-ISLAKACGHKNQLSQEQRSASELV------------NQVFQSS 296

  Fly   323 LPALAWANAADVWRLMCHRDEQDSRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFY 387
            ||                       :...|:.....|:...||.||:|||:||..:........:
Frog   297 LP-----------------------INKTSIFTTQKGMNDTMRYILIDWLVEVATMKDFSSLCLH 338

  Fly   388 LAVDYLDRYLHVAHKVQKTHLQLIGITCLFVAAKV--EEIYPPKIGEFAYVTDGACTERDILNHE 450
            :.|..:||||.: ..|.:..|||:||.|:.:..:.  :||.  .|.|..::||......|::...
Frog   339 MTVGLVDRYLKL-RSVPRAKLQLVGIACMVICTRFISKEIL--TIREAVWLTDNTYKYEDLVRMM 400

  Fly   451 KILLQALDWDISPITITGWLGVYMQLNVNNRTPASFSQIGRQKSAEADDAFIYPQFSGFEFVQTS 515
            ..::.||:..|...|:..:..|...|...:|:....                           .|
Frog   401 GEIISALEGKIRMPTVVDYKDVLSHLIPLDRSTLHL---------------------------CS 438

  Fly   516 QLLDLCTLDVGMANYSYSVLAAAA-----ISHTFSR----EMALRCSGLDWQVIQPCARWMEPFF 571
            .:.:|..|...::.||.:.|||.|     |.|..:|    ::| ..:|...:.:.||...:..
Frog   439 YISELSLLYTELSTYSPAQLAAGALLLARILHKQARPWPAQLA-ETTGFTLEHLTPCVVLLHK-- 500

  Fly   572 RVISQKAPYLQLNEQNEQVSNKFGLGLICPNIVTDDSHIIQTHTTTMDMYDEV---LMAQDAAH- 632
            :.....||     :...|||            :|......|.     |:||::   ....|.:|
Frog   501 KCFHDDAP-----KDYRQVS------------LTAVKQRFQD-----DLYDQISKEKQVMDHSHL 543

  Fly   633 ----AMRARIQASPATALRAPE--------------------------SLLTPPAS--SHKPDEY 665
                .:..|...|||:...|.:                          |.:|.|.:  |::.::.
Frog   544 CELLGVPCRDSESPASCPNAADFHQFLCSPSGSKTKRRREDSIQEDRGSFVTTPTAELSNQEEDL 608

  Fly   666 LGD-------------EGD---------ETGARSG-------ISSTTTCCNTAA----------- 690
            |||             |||         |..|.||       |:....|.:|.:
Frog   609 LGDFLDWSLETSCSGYEGDRESEGEREGEVTAPSGVLDLSLLITEHQQCQDTTSDDDSLVPLHPI 673

  Fly   691 -----------SNKG--GKSSSNNSVTS----CSSRSNP 712
                       |.:|  .|||..:||:|    .||.|.|
Frog   674 PLLSKLENGTHSTEGCAEKSSGYSSVSSGGSPTSSSSPP 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	32/130 (25%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	15/62 (24%)
ccnf	XP_012825809.1	FBOX	34..74	CDD:197608
		SLR repeat	87..111	CDD:276807
		Cyclin_N	301..412	CDD:365896	32/113 (28%)
		Cyclin_C	430..533	CDD:367282	27/154 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910