DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycE and ccne2

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001002075.1	Gene:	ccne2 / 415165	ZFINID:	ZDB-GENE-030131-9689	Length:	392	Species:	Danio rerio

Alignment Length:	428	Identity:	160/428 - (37%)
Similarity:	227/428 - (53%)	Gaps:	76/428 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 STISPASSGCSQQQAV---NGERTPGLPKHQEQIHHPVSD--------LMINMRTPMSPAVE--- 315
            :|:...:....||::.   .||....:|...::.|:.:.:        ..:.:.||.....:
Zfish     8 NTLQERNENAPQQKSQRKRKGECNRRVPSAAKKQHYEIQNRCFEGDVSASVLIETPQKEVQQETS 72

  Fly   316 --NGLRQ----------CPLPALAWANAADVWRLMCHRDEQDSRLRSI---SMLEQHPGLQPRMR 365
              :|.::          .|||.|:||::.|||..|.:::     |:.:   |.::||..|||:||
Zfish    73 NLSGFKRFRFKNLFVKPSPLPCLSWASSDDVWIKMLNKE-----LKYVHDKSFIQQHSALQPKMR 132

  Fly   366 AILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKI 430
            |||||||:||.|||.|||||||||.|..||::.....:.|..|||||||.||:|:|:|||||||:
Zfish   133 AILLDWLMEVSEVYTLHRETFYLAQDIFDRFMLTQKDIGKDQLQLIGITSLFIASKIEEIYPPKL 197

  Fly   431 GEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYMQLNVNNRTPASFSQIGRQKSA 495
            .||||||||||.|.:||..|.::|:||:||:.|.|:..||.:|.|::                |.
Zfish   198 QEFAYVTDGACNEEEILAKELVMLKALNWDLCPETVISWLKLYSQVD----------------SL 246

  Fly   496 EADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISHTFSREMALRCSGLDWQVI 560
            :.:..|:.||||...::|.:||||||.||:...:|.|.||||||..|..|.|:..:.|||.|..|
Zfish   247 KDEANFLIPQFSQETYIQITQLLDLCILDINSLDYQYGVLAAAAFCHFTSFELVHKVSGLTWDSI 311

  Fly   561 QPCARWMEPFFRVISQKAPYLQLNEQNEQVSNKFGLGLICPNIVTDDSHIIQTHTTTMDMYDEVL 625
            ..|.|||.||.|.: ::.|..:|.:..:              :.|||.|.||||...:.|..|..
Zfish   312 SNCVRWMNPFMRTV-REWPRPELKDFKK--------------VKTDDRHNIQTHVDYLTMLSEAH 361

  Fly   626 -MAQDAAHAMRARIQASPATALRAPESLLTPPASSHKP 662
             ..||:...|      ||    .|...:||||.|:.||
Zfish   362 DRQQDSVDRM------SP----MAVAGILTPPKSTEKP 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	75/131 (57%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	28/53 (53%)
ccne2	NP_001002075.1	Cyclin_N	102..229	CDD:278560	75/131 (57%)
ccne2	NP_001002075.1	Cyclin_C	232..353	CDD:281044	53/151 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579792
Domainoid	1	1.000	167	1.000	Domainoid score	I3811
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0002994
OrthoInspector	1	1.000	-	-		otm24735
orthoMCL	1	0.900	-	-		OOG6_105145
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2342
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.850