DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycE and Ccnb3

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	XP_038956227.1	Gene:	Ccnb3 / 317389	RGDID:	1564367	Length:	1405	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	118/531 - (22%)
Similarity:	207/531 - (38%)	Gaps:	157/531 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EPNGSIVTTAPSNGEVSSSIVVVVSSSSISSSSDSPIAILPHPDPIPSTSFSSASQR------SE 76
            |.:|::........|:||..:|.:..|.|:.......|.:        .|:::|::.      |.
  Rat   818 EASGALEEPLNIQEELSSEDIVAIMKSLITEDESIKEAFI--------RSYTTATEAPAEKSLSL 874

  Fly    77 EELPGTSAASRTDEMCSCDSQNLAASTAATS----NGNKRKRRLSSDSNEDPELGFE--PPSAKR 135
            ||......|:..:.:.|.:.......|....    ..|.|..||:        |.|:  |||
  Rat   875 EETSINEVATLKEPLSSQEKHRAELVTVLKELLVLVKNPRLERLA--------LAFQENPPS--- 928

  Fly   136 QQRLPALYGSEQGNLSSVASSVYTSPVVSVDGQST-------QELLSIRS--SPAEDLSEAPHSP 191
                         |:.::...|......|...:||       ||.||.::  ||.|.|:
  Rat   929 -------------NVETLLREVLALVEKSTGEESTLNEPLALQEKLSTKAELSPKELLA------ 974

  Fly   192 LPDSPDSPPSPDRGS----------KQTPVVVRYAAEQVVTSTV------------VTQKTEDDD 234
            |.|:|....:..:||          |.....:.::.|:....::            .|::....|
  Rat   975 LEDNPSFKKASPQGSLTFDHKPDIEKDEITRMSFSFEEFSIDSLYEKVLALSEGFTTTEQLSFTD 1039

  Fly   235 LLDDSCEDYSYDED---DEDDV-------EEEDD--------------------DVEIYSSTISP 269
            |       .::||.   ||:|:       |.|::                    .:|.::|.::
  Rat  1040 L-------QNFDESKIVDEEDIFKSFFVFENENNPNLSSNGFESRKDNSSAPMPSLEAFNSVMN- 1096

  Fly   270 ASSGC-----SQQQAVNGERTPGL-----PKHQEQIHHPVSDLMINMRTPMSPAVENGLRQCPLP 324
             |..|     |.|.::.|:.|..:     ...||......|||:::     |...:|
  Rat  1097 -SEPCVSATKSSQSSLGGKETEQVIILDDSDTQESFVKEDSDLLLS-----STYAKN-------- 1147

  Fly   325 ALAWANAADVWRLMCHRDEQDSRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLA 389
                        :..:..|::.:......:::...|...|||||:||::||...:::..||.|||
  Rat  1148 ------------IFIYLKEREEKFIVTKYMDEQMELTSDMRAILVDWMVEVQANFRMSHETLYLA 1200

  Fly   390 VDYLDRYLHVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILL 454
            |..:||||..| :.:|.||||:|.|...:|||.||.|||.:.||.|:.:....:.::::.|:.:|
  Rat  1201 VKLMDRYLMKA-QCEKNHLQLLGSTAYMIAAKFEESYPPSLTEFLYICEDLYPKSEMVSLERNIL 1264

  Fly   455 QALDWDIS-PI 464
            :.|::||: ||
  Rat  1265 KTLNFDINIPI 1275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	44/128 (34%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044
Ccnb3	XP_038956227.1	CYCLIN_SF	1133..1270	CDD:424085	48/162 (30%)
Ccnb3	XP_038956227.1	CYCLIN_SF	1274..1388	CDD:424085	2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820