DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycE and Ccna1

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001011949.1	Gene:	Ccna1 / 295052	RGDID:	1310639	Length:	421	Species:	Rattus norvegicus

Alignment Length:	471	Identity:	113/471 - (23%)
Similarity:	179/471 - (38%)	Gaps:	153/471 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 ELGFEPPSAKRQQR--LPALYGSEQGNLSSVASSVYTSPVVSVDGQSTQELLSIRS-SPAEDL-S 185
            :||.:||     ||  |..|..:||...:                 ..||:.:||. |.:|:: .
  Rat    29 QLGQDPP-----QRTVLGVLTENEQYRRA-----------------CGQEIATIRCFSGSENVFP 71

  Fly   186 EAPHSPLPDSPDSPPS----------PDRGSKQTPVVVRYAAEQVVTSTVVTQKTEDDDLLDDSC 240
            .|....|||:..|.|:          |::|.:                              |||
  Rat    72 AAGKKVLPDNGVSEPAKHGFDIYMDDPEQGDR------------------------------DSC 106

  Fly   241 ---EDYSYDEDDEDDVEEEDDDVE--IYSSTISP----ASSGCSQQQAVN-GERTPGLPKHQEQI 295
               |...:::..|.|......|:.  :..:|:||    :::....::|.: |.....:.::.|:|
  Rat   107 PGREGIVFEDVYEVDTSMLKSDLHFLLDFNTVSPMLVDSTAHAQSEEATDFGSDVINVTEYAEEI 171

  Fly   296 HHPVSDLMINMRTPMSPAVENGLRQCPLPALAWANAADVWRLMCHRDEQDSRLRSISMLEQHPGL 360
            |..:.:..:.                                  ||.:       ...:.:.|.:
  Rat   172 HRYLREAEVR----------------------------------HRPK-------AHYMRKQPDI 195

  Fly   361 QPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGITCLFVAAKVEEI 425
            ...|||||:|||:||.|.|||..||.||||::|||:|. ...|.:..|||:|...:.:|:|.|||
  Rat   196 TEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDRFLS-CMSVLRGKLQLVGTAAILLASKYEEI 259

  Fly   426 YPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYM-QLNVNNRTPASFSQI 489
            |||.:.||.|:||...|:|.:|..|.:||:.|.:|::..|...:|..|: :..|..||......:
  Rat   260 YPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCIRTENLAKYV 324

  Fly   490 GRQKSAEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAA-------ISHTFSRE 547
            ......|||.                           ...|..|::||||       ::..|..|
  Rat   325 AELSLLEADP---------------------------FLKYLPSLVAAAAYCLANYIVNRHFWPE 362

  Fly   548 MALRCSGLDWQVIQPC 563
            .....:|.....|.||
  Rat   363 TLAAFTGYSLNEIVPC 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	53/128 (41%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	12/54 (22%)
Ccna1	NP_001011949.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Cyclin_N2	27..>101	CDD:406812	23/93 (25%)
		CYCLIN_CCNA1_rpt1	132..294	CDD:410263	60/203 (30%)
		CYCLIN_CCNA1_rpt2	298..420	CDD:410266	21/108 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340028
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750