Protein Alignment CycE and Ccnb1

DIOPT Version :10

• Sequence 1: NP_001246037.1
• Gene: CycE / 34924
• FlyBaseID: FBgn0010382
• Length: 712
• Species: Drosophila melanogaster
• Sequence 2: NP_741988.1
• Gene: Ccnb1 / 25203
• RGDID: 2291
• Length: 423
• Species: Rattus norvegicus
• Alignment Length: 486
• Identity: 108/486 - (22%)
• Similarity: 171/486 - (35%)
• Gaps: 179/486 - (36%)

  Fly    69 SSASQRSEEELPGTSAASRTDEMCSCDSQNLAASTAATSNGNKRKRRLSSDSNEDPELGFEPPSA 133
            :..|....:.:|...|||:         ..|.:.||....|||                     .
  Rat    17 AKVSMAGAKRVPVAVAASK---------PLLRSRTALGDIGNK---------------------V 51

  Fly   134 KRQQRLPALYGSEQGNLSSVASSVYTSPVVSVDGQSTQELLSIRSSPAEDLSEAPHSPLPDSPDS 198
            ..|.|:|....:::....:|.......||..|  ...:..:.:.....|.:.|..|||.|...|:
  Rat    52 SEQSRIPLKKETKKLGSGTVTVKALPKPVDKV--PVCEPEVELDEPEPEPVMEVKHSPEPILVDT 114

  Fly   199 P-PSPDRGSKQTPVVVRYAAEQVVTSTVVTQKTEDDDLLDDSCEDYSYDEDDEDDVEEEDDDVEI 262
            | |||...|...|      ||:.:                  |:.:|              ||.:
  Rat   115 PSPSPMETSGCAP------AEEYL------------------CQAFS--------------DVIL 141

  Fly   263 YSSTISPASSG----CSQQQAVNGERTPGLPKHQEQIHHPVSDLMINMRTPMSPAVENGLRQCPL 323
            ..|.:.....|    ||:.                     |.|:...:|
  Rat   142 AVSDVDADDGGDPNLCSEY---------------------VKDIYAYLR---------------- 169

  Fly   324 PALAWANAADVWRLMCHRDEQDSRLRSISMLEQHPGLQPR----------MRAILLDWLIEVCEV 378
                                         .||:...::|:          |||||:||||:|...
  Rat   170 -----------------------------QLEEEQSVRPKYLLGREVTGNMRAILIDWLIQVQMK 205

  Fly   379 YKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTE 443
            ::|.:||.|:.|..:||::..: .|.|..|||:|:|.:|:|:|.||:|||:||:||:||:...|:
  Rat   206 FRLLQETMYMTVSIIDRFMQDS-CVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTNNTYTK 269

  Fly   444 RDILNHEKILLQALDWDISPITITGWLGVYMQLNVNNRTPASFSQIGRQKSAEADDAFIYPQFSG 508
            ..|...|..:|:.|::.         ||..:.|:...|.    |:||     |.|..
  Rat   270 HQIRQMEMKILRVLNFS---------LGRPLPLHFLRRA----SKIG-----EVDVE-------- 308

  Fly   509 FEFVQTSQLLDLCTLDVGMANYSYSVLAAAA 539
             :......|::|..||..|.:::.|.:||.|
  Rat   309 -QHTLAKYLMELSMLDYDMVHFAPSQIAAGA 338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	CYCLIN_CCNE_rpt1	327..459	CDD:410223	46/141 (33%)
		CYCLIN_CCNE_rpt2	463..576	CDD:410224	18/77 (23%)
Ccnb1	NP_741988.1	Trypan_PARP	<59..>130	CDD:368653	18/78 (23%)
		CYCLIN_CCNB1_rpt1	157..285	CDD:410268	51/194 (26%)
		Interaction with CDK2. /evidence=ECO:0000250	159..167		2/28 (7%)
		Interaction with CDK2. /evidence=ECO:0000250	248..251		1/2 (50%)
		CYCLIN_SF	290..409	CDD:477360	16/67 (24%)