DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycE and Ccne2

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001032211.1	Gene:	Ccne2 / 12448	MGIID:	1329034	Length:	404	Species:	Mus musculus

Alignment Length:	404	Identity:	145/404 - (35%)
Similarity:	205/404 - (50%)	Gaps:	83/404 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 KHQEQIHHPVSDLMINMRTPMSPAVENGLRQC-------------------------------PL 323
            |||.:|           |....|.:..|:..|                               ||
Mouse    49 KHQYEI-----------RNCWPPVLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPL 102

  Fly   324 PALAWANAADVWRLMCHRDEQDSRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYL 388
            |.|:||.:.:||:.|..::.:....:...:|  |..|:|:||:||||||:||||||.||||||||
Mouse   103 PDLSWACSQEVWQNMLQKENRYVHDKHFQVL--HSDLEPQMRSILLDWLLEVCEVYTLHRETFYL 165

  Fly   389 AVDYLDRYLHVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKIL 453
            |.|:.||::.....|.|..|||||||.||:|:|:||||.||:.||||||||||:|.|||..|..:
Mouse   166 AQDFFDRFMLTQKDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNI 230

  Fly   454 LQALDWDISPITITGWLGVYMQLNVNNRTPASFSQIGRQKSAEADDAFIYPQFSGFEFVQTSQLL 518
            |:||.|::.|:|:..||.:::|::.....|                ..:.||:|...|:|.:|||
Mouse   231 LKALKWELCPVTVISWLNLFLQVDAVKDVP----------------KVLLPQYSQETFIQIAQLL 279

  Fly   519 DLCTLDVGMANYSYSVLAAAAISHTFSREMALRCSGLDWQVIQPCARWMEPFFRVISQKAPYLQL 583
            |||.|.:....:.|.:|||||:.|..|.|:..:.|||:|..|..|..||.||..|:...:| ::|
Mouse   280 DLCILAIDSLEFQYRILAAAALCHFTSIEVVKKASGLEWDDISECVDWMVPFVSVVKSVSP-VKL 343

  Fly   584 NEQNEQVSNKFGLGLICPNIVTDDSHIIQTHTTTMDMYDEVLMAQDAAHAMRARIQASPATALRA 648
            ....:              |..:|.|.|||||..:.:.:||    :..:..|...|.||.    .
Mouse   344 KTFKK--------------IPMEDRHNIQTHTNYLALLNEV----NYVNIYRKGGQLSPV----C 386

  Fly   649 PESLLTPPASSHKP 662
            ...::|||.|:.||
Mouse   387 NGGIMTPPKSTEKP 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	71/128 (55%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	24/53 (45%)
Ccne2	NP_001032211.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		Cyclin_N	112..239	CDD:365896	71/128 (55%)
		Cyclin_C	241..361	CDD:367282	45/150 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836318
Domainoid	1	1.000	160	1.000	Domainoid score	I4041
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2952
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0002994
OrthoInspector	1	1.000	-	-		otm43236
orthoMCL	1	0.900	-	-		OOG6_105145
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2444
SonicParanoid	1	1.000	-	-		X2342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790