DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycE and Ccne1

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_031659.2	Gene:	Ccne1 / 12447	MGIID:	88316	Length:	408	Species:	Mus musculus

Alignment Length:	474	Identity:	175/474 - (36%)
Similarity:	244/474 - (51%)	Gaps:	85/474 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 DSPDSPPSPDRGSKQTPVVVRYAAEQVVTSTVVTQKTEDDDL--LDDSCEDYSYDEDDEDDVEEE 256
            ||.|.....:.|.....|..|.....|    .|..:..|:::  :|.:.:       .||..:..
Mouse     6 DSTDHSNMKEEGGSDLSVRSRKRKANV----AVFLQDPDEEIAKIDKTVK-------SEDSSQPW 59

  Fly   257 DDDVEIYSSTISPASSGCSQQQAVNGERTPGLPKHQEQIHHPVSDLMINMRTPMSPAVENGLRQC 321
            ||:    |:.:.|    ||.....|.|       ...::.:|        ||...|......|..
Mouse    60 DDN----SACVDP----CSFIPTPNKE-------EDNELEYP--------RTAFQPRKIRPPRAS 101

  Fly   322 PLPALAWANAADVWRLMCHRDEQDSRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETF 386
            |||.|.|.|..:|||:|.::::  :.||....|::||.||.||||:|||||:|||||||||||||
Mouse   102 PLPVLNWGNREEVWRIMLNKEK--TYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEVYKLHRETF 164

  Fly   387 YLAVDYLDRYLHVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEK 451
            |||.|:.|||:...|.:.||.||||||:.||:|:|:|||||||:.:|||||||||:..:||..|.
Mouse   165 YLAQDFFDRYMASQHNIIKTLLQLIGISALFIASKLEEIYPPKLHQFAYVTDGACSGDEILTMEL 229

  Fly   452 ILLQALDWDISPITITGWLGVYMQLNVNNRTPASFSQIGRQKSAEADDAFIYPQFSGFEFVQTSQ 516
            ::::||.|.:||:||..||.||:|:...|.|                ...:.||:....|||.::
Mouse   230 MMMKALKWRLSPLTIVSWLNVYVQVAYVNDT----------------GEVLMPQYPQQVFVQIAE 278

  Fly   517 LLDLCTLDVGMANYSYSVLAAAAISHTFSREMALRCSGLDWQVIQPCARWMEPFFRVI----SQK 577
            |||||.||||...:.|.||||:|:.|..|.|:..:.||..|..|:.|.:||.||..||    |.|
Mouse   279 LLDLCVLDVGCLEFPYGVLAASALYHFSSLELMQKVSGYQWCDIEKCVKWMVPFAMVIREMGSSK 343

  Fly   578 APYLQLNEQNEQVSNKFGLGLICPNIVTDDSHIIQTHTTTMDMYDEVLMAQDAAHAMRARIQASP 642
            ..:.:                   .:..:|||.|||||.::|:.|:. .|:.|..:.:.||...|
Mouse   344 LKHFR-------------------GVPMEDSHNIQTHTNSLDLLDKA-QAKKAILSEQNRISPPP 388

  Fly   643 ATALRAPESLLTPPASSHK 661
            :.       :||||.||.|
Mouse   389 SV-------VLTPPPSSKK 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	75/128 (59%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	26/53 (49%)
Ccne1	NP_031659.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		5/20 (25%)
		Cyclin_N	113..240	CDD:278560	75/128 (59%)
		Cyclin_C	243..362	CDD:281044	51/153 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..408		10/29 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836356
Domainoid	1	1.000	160	1.000	Domainoid score	I4041
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H14452
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2952
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	1	1.000	-	-		FOG0002994
OrthoInspector	1	1.000	-	-		otm43236
orthoMCL	1	0.900	-	-		OOG6_105145
Panther	1	1.100	-	-	LDO	PTHR10177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2444
SonicParanoid	1	1.000	-	-		X2342
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790