DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycE and Ccna1

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001292150.1	Gene:	Ccna1 / 12427	MGIID:	108042	Length:	421	Species:	Mus musculus

Alignment Length:	235	Identity:	75/235 - (31%)
Similarity:	110/235 - (46%)	Gaps:	39/235 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 HRDEQDSRLR---SISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAH 401
            ||..:::.:|   ....:.:.|.:...|||||:|||:||.|.|||..||.||||::|||:|. ..
Mouse   172 HRYLREAEVRHRPKAHYMRKQPDITEGMRAILVDWLVEVGEEYKLRTETLYLAVNFLDRFLS-CM 235

  Fly   402 KVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITI 466
            .|.:..|||:|...:.:|:|.||||||.:.||.|:||...|:|.:|..|.:||:.|.:|::..|.
Mouse   236 SVLRGKLQLVGTAAILLASKYEEIYPPDVDEFVYITDDTYTKRQLLRMEHLLLKVLAFDLTVPTT 300

  Fly   467 TGWLGVYM-QLNVNNRTPASFSQIGRQKSAEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANY 530
            ..:|..|: :..|..||......:......|||.                           ...|
Mouse   301 NQFLLQYLRRQGVCIRTENLAKYVAELSLLEADP---------------------------FLKY 338

  Fly   531 SYSVLAAAA-------ISHTFSREMALRCSGLDWQVIQPC 563
            ..|::||||       ::..|..|.....:|.....|.||
Mouse   339 LPSLVAAAAYCLANYIVNRHFWPETLAAFTGYSLNEIVPC 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	54/124 (44%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	12/54 (22%)
Ccna1	NP_001292150.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Cyclin_N2	27..>101	CDD:406812
		CYCLIN_CCNA1_rpt1	132..294	CDD:410263	53/122 (43%)
		CYCLIN_CCNA1_rpt2	298..420	CDD:410266	21/108 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836360
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D993640at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750