DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycE and Ccnf

DIOPT Version :9

Sequence 1:	NP_001246037.1	Gene:	CycE / 34924	FlyBaseID:	FBgn0010382	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	XP_038941012.1	Gene:	Ccnf / 117524	RGDID:	67401	Length:	818	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	98/479 - (20%)
Similarity:	157/479 - (32%)	Gaps:	163/479 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 MCHRDEQDSRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHK 402
            :|...:....:....:.....||...||.||:|||:||..:........:|.|:.:||||. ...
  Rat   321 VCQLFQASQAVNKQQIFSVQKGLSDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLR-RRL 384

  Fly   403 VQKTHLQLIGITCLFVAAKV--EEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPIT 465
            |.:..|||:||.|:.:..:.  :||.  .|.|..::||......|::.....::.||:..|...|
  Rat   385 VPRYKLQLLGIACMVICTRFISKEIL--TIREAVWLTDNTYKYEDLVRVMGEIISALEGKIRIPT 447

  Fly   466 ITGWLGVYMQL-NVNNRTP--ASFSQIGRQKSAEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGM 527
            :..:..|.:.| .|..||.  .||                              |.:|..|...:
  Rat   448 VVDYKEVLLTLVPVAPRTQHLCSF------------------------------LCELTLLHTSL 482

  Fly   528 ANYSYSVLAAAAI-------SHTFSREMAL-RCSGLDWQVIQPCARWMEPFFRVISQKAP--YLQ 582
            :.|:.:.||:||:       .||......| ..:|..:..:.||...:..  :.....||  |.|
  Rat   483 SVYAPARLASAALLLARLMHGHTQPWTTQLWDLTGFSYSDLTPCVLSLHK--KCFHDDAPKDYRQ 545

  Fly   583 --LNEQNEQVSNKFGLGLICPNIVTDDSHIIQTHTTTMDMYDEVLMAQDAAHAMRARIQASPA-- 643
              |....::..:|      |...::.               :|||...:...|:..: |.||.
  Rat   546 VSLTAVKQRFEDK------CYEEISQ---------------EEVLSYAELCSALGVK-QESPEPP 588

  Fly   644 ---------TALRAPES------------------LLTPPASSHKPDE----------------Y 665
                     |.|.:|..                  :.||.|.....:|                |
  Rat   589 SFPSSGEIHTFLSSPSGRRSKRKRENSLQEDRGSFVTTPTAELSNQEETLLGSLLDWSLDCCSGY 653

  Fly   666 LGD---EGDETG---ARSGISSTTT--------CCNTAAS------------------------- 691
            .||   ||::.|   |.||:...|.        ||..::.
  Rat   654 EGDQESEGEKEGDVTAPSGLLDVTVVYLNPEEHCCQESSDEEVWPEDKSHPTPGTQAPPASAPWP 718

  Fly   692 ---NKG--GKSSSNNSVTSCSSRS 710
               |:|  ||..:.:..:|.||.|
  Rat   719 LPCNRGDPGKDVTTSGYSSVSSSS 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	Cyclin_N	333..462	CDD:278560	34/125 (27%)
CycE	NP_001246037.1	Cyclin_C	<517..>571	CDD:281044	14/61 (23%)
Ccnf	XP_038941012.1	FBOX	73..111	CDD:197608
		CYCLIN_CCNF_rpt1	345..439	CDD:410225	29/96 (30%)
		CYCLIN_CCNF_rpt2	467..578	CDD:410226	26/163 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340023
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.830