Protein Alignment stol and CACNA2D4

DIOPT Version :10

• Sequence 1: NP_001188817.2
• Gene: stol / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: NP_758952.4
• Gene: CACNA2D4 / 93589
• HGNCID: 20202
• Length: 1137
• Species: Homo sapiens
• Alignment Length: 1247
• Identity: 360/1247 - (28%)
• Similarity: 584/1247 - (46%)
• Gaps: 240/1247 - (19%)

  Fly    34 IPHNEVRNWALKFGVDLWEFGRQFTKMNEIKSRFKD--NDIEVKRKDGIILLRELAAEVKNFMDF 96
            ||...|:.||..||.||:....:::....::.::||  :.::::..||:.|:|:.:.:::|.:..
Human    72 IPLETVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVESSLKIEEVDGLELVRKFSEDMENMLRR 136

  Fly    97 KRNAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYDARRINEYNADGKLADGARHMDIRFMRRF 161
            |..||..|:::||:|.|:....:...      ..:|::..|||.:..|...:......:.....|
Human   137 KVEAVQNLVEAAEEADLNHEFNESLV------FDYYNSVLINERDEKGNFVELGAEFLLESNAHF 195

  Fly   162 ERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRRFP 226
            ..||||.|:||:.:|..|...:||:.:.:..|..|:.:|..|.::||.|:||||||:|||.|.:|
Human   196 SNLPVNTSISSVQLPTNVYNKDPDILNGVYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYP 260

  Fly   227 GTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLGE 291
            |..|.|:  :...:..|.|...|::|||:|||||:||:|.|.||......:...|...|||||||
Human   261 GIKWTPD--ENGVITFDCRNRGWYIQAATSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGE 323

  Fly   292 DDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHKYN 356
            :||:|:|.:::.|....||||..:|:|..||.:..|..|:.:.::........|..||.:|.::.
Human   324 NDFINIIAYNDYVHYIEPCFKGILVQADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQ 388

  Fly   357 QSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKGFF 421
            ::..||.||||||||::...|.::.|.::||||...||:||||||.:......:..:||:|||::
Human   389 EAKQGSLCNQAIMLISDGAVEDYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYY 453

  Fly   422 VQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVFVAGKSGGLGRDSEYQRRLVTTVSTPV 486
            .||:...:.:..|::|..|::|||:: ..||.:.|:..::..|   |.........|:|||:.||
Human   454 TQISTLADTQENVMEYLHVLSRPMVI-NHDHDIIWTEAYMDSK---LLSSQAQSLTLLTTVAMPV 514

  Fly   487 FDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLGDANQY 551
            |.::|.:.....||||||:||.:.|:.|:.|::|||.:||:|:..|||.:|.|||||||....:
Human   515 FSKKNETRSHGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGK- 578

  Fly   552 IDQLKPK--YASVDITELELPETEFGNNNEPIEINKNLLNEMRGDMIKPKEGETEFTVMNHYDDS 614
              :||||  |.|||::|:|.               ::....:|..||..:.|.....|....|..
Human   579 --KLKPKPNYNSVDLSEVEW---------------EDQAESLRTAMINRETGTLSMDVKVPMDKG 626

  Fly   615 KRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVSQQEIRHSRNNVTEYFKGDNWRVHP---- 675
            |||...|:.||:..|.||||:|.:||...:|.:..:....:....:::          :||
Human   627 KRVLFLTNDYFFTDISDTPFSLGVVLSRGHGEYILLGNTSVEEGLHDL----------LHPDLAL 681

  Fly   676 --DWVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQP 738
              ||:||    ::|::.:.....:.             |.::.||:|             |.|..
Human   682 AGDWIYC----ITDIDPDHRKLSQL-------------EAMIRFLTR-------------KDPDL 716

  Fly   739 HHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDRNTT--GSS 801
            .                                   ||..|::.::.||:||..::...|  ..:
Human   717 E-----------------------------------CDEELVREVLFDAVVTAPMEAYWTALALN 746

  Fly   802 SGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLR---WIDHVK---RPEDTPEPHFSEDN 860
            ..:|.:|                 ||..:|:.||:||||   ::...|   |...|||   .|.:
Human   747 MSEESEH-----------------VVDMAFLGTRAGLLRSSLFVGSEKVSDRKFLTPE---DEAS 791

  Fly   861 VRAMD--TSWYKRAIDQHSVEPDSFVYSVPFGSGYAIKSNATLVTASHAIFVEHRGHKAAAGVVG 923
            |..:|  ..||::| .:|..  .|||:::.:..|........:||||.|:.|......|.|...|
Human   792 VFTLDRFPLWYRQA-SEHPA--GSFVFNLRWAEGPESAGEPMVVTASTAVAVTVDKRTAIAAAAG 853

  Fly   924 LQFQHDSLAKHFINITSACTGMTG-CKRTCASDNLDCYVLDNSGFVIISEEMEHTGKFFGQIDGT 987
            :|.:.:.|.:.|...|..|:.:.| |.::|...:|||:|:||:||::||:....||:|.|::||.
Human   854 VQMKLEFLQRKFWAATRQCSTVDGPCTQSCEDSDLDCFVIDNNGFILISKRSRETGRFLGEVDGA 918

  Fly   988 IMDSLVQDRIYKRVTVNDYQGVCSDADNPYTAAGGILKP-------NRLGSWFFNHLLALSAAWL 1045
            ::..|:...::.:||:.|||.:|..:.:.::||..::.|       .|   |....|:.....|
Human   919 VLTQLLSMGVFSQVTMYDYQAMCKPSSHHHSAAQPLVSPISAFLTATR---WLLQELVLFLLEW- 979

  Fly  1046 SLMPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVEYTTPPP 1110
                   ..|                   ...|:.|                   |:.:......
Human   980 -------SVW-------------------GSWYDRG-------------------AEAKSVFHHS 999

  Fly  1111 RQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERPFSVQKI 1175
            .:||       ..||  .:.||....:::.||......|        :..|  ..|::.|.||:|
Human  1000 HKHK-------KQDP--LQPCDTEYPVFVYQPAIREANG--------IVEC--GPCQKVFVVQQI 1045

  Fly  1176 PHSNLILLVVDTLCPCGSKQLDIEP--LEEAGVIG-----ACSTRRQGQEQESRRRPKKCINYHP 1233
            |:|||:|||.|..|.|     .|.|  |:||..:.     .|...|   .|:.||||..|..:||
Human  1046 PNSNLLLLVTDPTCDC-----SIFPPVLQEATEVKYNASVKCDRMR---SQKLRRRPDSCHAFHP 1102

  Fly  1234 EEIEIQQCGRGS 1245
            || ..|.||..|
Human  1103 EE-NAQDCGGAS 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stol	NP_001188817.2	VWA_N	130..230	CDD:462464	36/99 (36%)
		vWA_VGCC_like	245..428	CDD:238740	74/182 (41%)
		PDC2_MCP_like	511..643	CDD:350337	50/133 (38%)
		VGCC_alpha2	810..>1048	CDD:462488	72/253 (28%)
CACNA2D4	NP_758952.4	VWA_N	148..264	CDD:462464	40/121 (33%)
		vWA_VGCC_like	277..460	CDD:238740	74/182 (41%)
		MIDAS-like motif	297..301		2/3 (67%)
		HK_sensor	<484..537	CDD:365792	19/55 (35%)
		HK_sensor	539..654	CDD:365792	50/132 (38%)
		VGCC_alpha2	661..1110	CDD:462488	142/623 (23%)