DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4587 and CACNA2D4

DIOPT Version :9

Sequence 1:NP_001188817.2 Gene:CG4587 / 34921 FlyBaseID:FBgn0028863 Length:1271 Species:Drosophila melanogaster
Sequence 2:NP_758952.4 Gene:CACNA2D4 / 93589 HGNCID:20202 Length:1137 Species:Homo sapiens


Alignment Length:1247 Identity:360/1247 - (28%)
Similarity:584/1247 - (46%) Gaps:240/1247 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 IPHNEVRNWALKFGVDLWEFGRQFTKMNEIKSRFKD--NDIEVKRKDGIILLRELAAEVKNFMDF 96
            ||...|:.||..||.||:....:::....::.::||  :.::::..||:.|:|:.:.:::|.:..
Human    72 IPLETVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVESSLKIEEVDGLELVRKFSEDMENMLRR 136

  Fly    97 KRNAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYDARRINEYNADGKLADGARHMDIRFMRRF 161
            |..||..|:::||:|.|:....:...      ..:|::..|||.:..|...:......:.....|
Human   137 KVEAVQNLVEAAEEADLNHEFNESLV------FDYYNSVLINERDEKGNFVELGAEFLLESNAHF 195

  Fly   162 ERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRRFP 226
            ..||||.|:||:.:|..|...:||:.:.:..|..|:.:|..|.::||.|:||||||:|||.|.:|
Human   196 SNLPVNTSISSVQLPTNVYNKDPDILNGVYMSEALNAVFVENFQRDPTLTWQYFGSATGFFRIYP 260

  Fly   227 GTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLGE 291
            |..|.|:  :...:..|.|...|::|||:|||||:||:|.|.||......:...|...|||||||
Human   261 GIKWTPD--ENGVITFDCRNRGWYIQAATSPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGE 323

  Fly   292 DDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHKYN 356
            :||:|:|.:::.|....||||..:|:|..||.:..|..|:.:.::........|..||.:|.::.
Human   324 NDFINIIAYNDYVHYIEPCFKGILVQADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQ 388

  Fly   357 QSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKGFF 421
            ::..||.||||||||::...|.::.|.::||||...||:||||||.:......:..:||:|||::
Human   389 EAKQGSLCNQAIMLISDGAVEDYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYY 453

  Fly   422 VQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVFVAGKSGGLGRDSEYQRRLVTTVSTPV 486
            .||:...:.:..|::|..|::|||:: ..||.:.|:..::..|   |.........|:|||:.||
Human   454 TQISTLADTQENVMEYLHVLSRPMVI-NHDHDIIWTEAYMDSK---LLSSQAQSLTLLTTVAMPV 514

  Fly   487 FDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLGDANQY 551
            |.::|.:.....||||||:||.:.|:.|:.|::|||.:||:|:..|||.:|.|||||||....: 
Human   515 FSKKNETRSHGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGK- 578

  Fly   552 IDQLKPK--YASVDITELELPETEFGNNNEPIEINKNLLNEMRGDMIKPKEGETEFTVMNHYDDS 614
              :||||  |.|||::|:|.               ::....:|..||..:.|.....|....|..
Human   579 --KLKPKPNYNSVDLSEVEW---------------EDQAESLRTAMINRETGTLSMDVKVPMDKG 626

  Fly   615 KRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVSQQEIRHSRNNVTEYFKGDNWRVHP---- 675
            |||...|:.||:..|.||||:|.:||...:|.:..:....:....:::          :||    
Human   627 KRVLFLTNDYFFTDISDTPFSLGVVLSRGHGEYILLGNTSVEEGLHDL----------LHPDLAL 681

  Fly   676 --DWVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQP 738
              ||:||    ::|::.:.....:.             |.::.||:|             |.|..
Human   682 AGDWIYC----ITDIDPDHRKLSQL-------------EAMIRFLTR-------------KDPDL 716

  Fly   739 HHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDRNTT--GSS 801
            .                                   ||..|::.::.||:||..::...|  ..:
Human   717 E-----------------------------------CDEELVREVLFDAVVTAPMEAYWTALALN 746

  Fly   802 SGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLR---WIDHVK---RPEDTPEPHFSEDN 860
            ..:|.:|                 ||..:|:.||:||||   ::...|   |...|||   .|.:
Human   747 MSEESEH-----------------VVDMAFLGTRAGLLRSSLFVGSEKVSDRKFLTPE---DEAS 791

  Fly   861 VRAMD--TSWYKRAIDQHSVEPDSFVYSVPFGSGYAIKSNATLVTASHAIFVEHRGHKAAAGVVG 923
            |..:|  ..||::| .:|..  .|||:::.:..|........:||||.|:.|......|.|...|
Human   792 VFTLDRFPLWYRQA-SEHPA--GSFVFNLRWAEGPESAGEPMVVTASTAVAVTVDKRTAIAAAAG 853

  Fly   924 LQFQHDSLAKHFINITSACTGMTG-CKRTCASDNLDCYVLDNSGFVIISEEMEHTGKFFGQIDGT 987
            :|.:.:.|.:.|...|..|:.:.| |.::|...:|||:|:||:||::||:....||:|.|::||.
Human   854 VQMKLEFLQRKFWAATRQCSTVDGPCTQSCEDSDLDCFVIDNNGFILISKRSRETGRFLGEVDGA 918

  Fly   988 IMDSLVQDRIYKRVTVNDYQGVCSDADNPYTAAGGILKP-------NRLGSWFFNHLLALSAAWL 1045
            ::..|:...::.:||:.|||.:|..:.:.::||..::.|       .|   |....|:.....| 
Human   919 VLTQLLSMGVFSQVTMYDYQAMCKPSSHHHSAAQPLVSPISAFLTATR---WLLQELVLFLLEW- 979

  Fly  1046 SLMPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVEYTTPPP 1110
                   ..|                   ...|:.|                   |:.:......
Human   980 -------SVW-------------------GSWYDRG-------------------AEAKSVFHHS 999

  Fly  1111 RQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERPFSVQKI 1175
            .:||       ..||  .:.||....:::.||......|        :..|  ..|::.|.||:|
Human  1000 HKHK-------KQDP--LQPCDTEYPVFVYQPAIREANG--------IVEC--GPCQKVFVVQQI 1045

  Fly  1176 PHSNLILLVVDTLCPCGSKQLDIEP--LEEAGVIG-----ACSTRRQGQEQESRRRPKKCINYHP 1233
            |:|||:|||.|..|.|     .|.|  |:||..:.     .|...|   .|:.||||..|..:||
Human  1046 PNSNLLLLVTDPTCDC-----SIFPPVLQEATEVKYNASVKCDRMR---SQKLRRRPDSCHAFHP 1102

  Fly  1234 EEIEIQQCGRGS 1245
            || ..|.||..|
Human  1103 EE-NAQDCGGAS 1113

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4587NP_001188817.2 VWA_N 108..230 CDD:285584 40/121 (33%)
vWA_VGCC_like 245..428 CDD:238740 74/182 (41%)
Cache_1 456..544 CDD:280839 36/87 (41%)
VGCC_alpha2 590..>647 CDD:285647 21/56 (38%)
CACNA2D4NP_758952.4 VWA_N 148..264 CDD:285584 40/121 (33%)
vWA_VGCC_like 277..460 CDD:238740 74/182 (41%)
MIDAS-like motif 297..301 2/3 (67%)
Cache_1 487..579 CDD:280839 39/97 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 125 1.000 Domainoid score I5480
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H26544
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D110668at33208
OrthoFinder 1 1.000 - - FOG0000496
OrthoInspector 1 1.000 - - mtm8612
orthoMCL 1 0.900 - - OOG6_103783
Panther 1 1.100 - - LDO PTHR10166
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X365
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.920

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