Protein Alignment stol and CACNA2D1

DIOPT Version :10

• Sequence 1: NP_001188817.2
• Gene: stol / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: XP_006716181.1
• Gene: CACNA2D1 / 781
• HGNCID: 1399
• Length: 1110
• Species: Homo sapiens
• Alignment Length: 1314
• Identity: 320/1314 - (24%)
• Similarity: 547/1314 - (41%)
• Gaps: 308/1314 - (23%)

  Fly     8 CFVAIVLGVLIFKMHIFVAFADQDEDIPHN-EVRNWALKFGVDLWEFGRQFTKMNEIKSRF-KDN 70
            |.:|:.|  .:|:.  .:.....:|..|.. .:::|..|...||....:..:.:|::...: |..
Human     5 CLLALTL--TLFQS--LLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQ 65

  Fly    71 DIEVKRKDGIILLRELAA-EVKNFMDFKRNAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYDA 134
            |:.....:....|.|:|| :::..:..:..|::||...||           :.::....::.:.:
Human    66 DLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAE-----------KVQAAHQWREDFAS 119

  Fly   135 RRINEYNADGKL-------ADGARHM------DIRFMRRFERLPVNLSLSSILVPHGVDLDEPDV 186
            ..:..|||...|       ..|::.:      |..|.|:     ::...:::.:|..:......|
Human   120 NEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQ-----ISYQHAAVHIPTDIYEGSTIV 179

  Fly   187 KSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRRFPGTAWPPEGSKGSKL-IHDFRTHNWF 250
            .:.|.|:..||.:|:.|.|:||:|.||.|||:||..|.:|.:.|.......:|: ::|.|...|:
Human   180 LNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWY 244

  Fly   251 VQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLGEDDFVNLITFSEVVKTPVPCFKDRM 315
            :|.|:||||::||:|.|.|::..:..|...:...:|:||.:|||||:.:|:...: .|.||: .:
Human   245 IQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQ-DVSCFQ-HL 307

  Fly   316 VRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHKYNQSGAGSQCNQAIMLITESTSESHK 380
            |:|...|.:.:|.||..|..:...::..|..:||..|..||.|.|  .||:.|||.|:...|..:
Human   308 VQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRA--NCNKIIMLFTDGGEERAQ 370

  Fly   381 DVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKGFFVQINDYDEARRKVIDYALVMARPM 445
            ::..:|| ....||:||:.:|..:..|..:..|||.|||::.:|......|....:|..|:.|||
Human   371 EIFNKYN-KDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPM 434

  Fly   446 IMY-QADHPVHWSPVFVAGKSGGLGRDSEYQRRLVTTVSTPVFDRRNHSVRVANL-----LGVVG 504
            ::. .....|.|:.|::.....|          ||.|.:.|||:.........||     |||:|
Human   435 VLAGDKAKQVQWTNVYLDALELG----------LVITGTLPVFNITGQFENKTNLKNQLILGVMG 489

  Fly   505 TDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLGDANQYIDQLKPKYASVDITELEL 569
            .||.:|:|:::.|:..|.||||.|.:|.||.||.||:|:|           ||  ..|.|..:.|
Human   490 VDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQP-----------KP--IGVGIPTINL 541

  Fly   570 ----PETEFGNNNEPI-------EINKNLLNEMRGDMIKPKEGETEFTVMNHYDDSKRVSTRTHR 623
                |..:...:.||:       |:..::..|:|..||..:.||..|..:....|.:.:......
Human   542 RKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRT 606

  Fly   624 YFYGPIEDTPFTLAIVLPE------KYGSHEFVSQQEIRHSRNNVTEYFKGDNWR------VHP- 675
            |.:.|:..|.::||:|||.      |....|.::|...:..:...:|..|.||:.      :.|
Human   607 YTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARSKKGKMKDSETLKPDNFEESGYTFIAPR 671

  Fly   676 DWVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQPHH 740
            |  ||....:||      ::.|:.....|            |:.|             |:|
Human   672 D--YCNDLKISD------NNTEFLLNFNE------------FIDR-------------KTP---- 699

  Fly   741 NMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDRNTTGSSSGKE 805
                     |.|.                     |:..|:..::.||..|:.|.:|....
Human   700 ---------NNPS---------------------CNADLINRVLLDAGFTNELVQNYWSK----- 729

  Fly   806 DKHPIATLMAILKRQGYQKFV--VATSFVATRSGLLRWIDHVKRPEDTPEPHFSEDNVRAMDTSW 868
                             ||.:  |...||.|..|:.|     ..|::..|..  ::|....:.|:
Human   730 -----------------QKNIKGVKARFVVTDGGITR-----VYPKEAGENW--QENPETYEDSF 770

  Fly   869 YKRAIDQHSVEPDSFVYSVPF--GSGYAIKSNATLVTASHAIFVEHRGHKAAAGVVGLQFQHDSL 931
            |||::|.     |::|::.|:  .||.....:..:|:.:..|:::.:..|.|  |||::...:|.
Human   771 YKRSLDN-----DNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPA--VVGIKIDVNSW 828

  Fly   932 AKHF--INITSACTG-MTGCKRTCASDNLDCYVLDNSGFVIISEEMEHT---GKFFGQIDGTIMD 990
            .::|  .:|...|.| :..|||.  ||.:||.:||:.||::::...::|   |:|||:||.::|.
Human   829 IENFTKTSIRDPCAGPVCDCKRN--SDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMR 891

  Fly   991 SLVQDRIYKRVTVNDYQGVCSDADNPYTAAG-------GILKPNRLGSWFFNHLLALSAAW---- 1044
            .||...:|......|||.||.....|...||       .:....::|.|      |.:|||
Human   892 HLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVADILQIGWW------ATAAAWSILQ 950

  Fly  1045 ---LSL-MPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVEY 1105
               ||| .|..|.|                                   |:.|.|:|  ||.:
Human   951 QFLLSLTFPRLLEA-----------------------------------VEMEDDDF--TASL-- 976

  Fly  1106 TTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERPF 1170
                                 :.:.|......|....:..:..|        :.:|  ..|.|.|
Human   977 ---------------------SKQSCITEQTQYFFDNDSKSFSG--------VLDC--GNCSRIF 1010

  Fly  1171 SVQKIPHSNLILLVVDT--LCPCGSKQLDIEPLEEAGVIGACSTRRQGQEQESRRRPKKCINYHP 1233
            ..:|:.::|||.::|::  .|||.::.| |:..:.:.....|...:|   ...|:.|..|.:.:.
Human  1011 HGEKLMNTNLIFIMVESKGTCPCDTRLL-IQAEQTSDGPNPCDMVKQ---PRYRKGPDVCFDNNV 1071

  Fly  1234 EEIEIQQCGRGSTL 1247
            .| :...||..|.|
Human  1072 LE-DYTDCGGVSGL 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stol	NP_001188817.2	VWA_N	130..230	CDD:462464	29/112 (26%)
		vWA_VGCC_like	245..428	CDD:238740	63/182 (35%)
		PDC2_MCP_like	511..643	CDD:350337	42/148 (28%)
		VGCC_alpha2	810..>1048	CDD:462488	72/262 (27%)
CACNA2D1	XP_006716181.1	VWA_N	104..223	CDD:462464	31/134 (23%)
		vWA_VGCC_like	239..417	CDD:238740	63/182 (35%)
		dCache_1	<435..>529	CDD:460673	35/103 (34%)
		VGCC_alpha2	651..1079	CDD:462488	129/613 (21%)