DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4587 and CACNA2D1

DIOPT Version :9

Sequence 1:NP_001188817.2 Gene:CG4587 / 34921 FlyBaseID:FBgn0028863 Length:1271 Species:Drosophila melanogaster
Sequence 2:XP_006716181.1 Gene:CACNA2D1 / 781 HGNCID:1399 Length:1110 Species:Homo sapiens


Alignment Length:1314 Identity:320/1314 - (24%)
Similarity:547/1314 - (41%) Gaps:308/1314 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 CFVAIVLGVLIFKMHIFVAFADQDEDIPHN-EVRNWALKFGVDLWEFGRQFTKMNEIKSRF-KDN 70
            |.:|:.|  .:|:.  .:.....:|..|.. .:::|..|...||....:..:.:|::...: |..
Human     5 CLLALTL--TLFQS--LLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQ 65

  Fly    71 DIEVKRKDGIILLRELAA-EVKNFMDFKRNAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYDA 134
            |:.....:....|.|:|| :::..:..:..|::||...||           :.::....::.:.:
Human    66 DLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAE-----------KVQAAHQWREDFAS 119

  Fly   135 RRINEYNADGKL-------ADGARHM------DIRFMRRFERLPVNLSLSSILVPHGVDLDEPDV 186
            ..:..|||...|       ..|::.:      |..|.|:     ::...:::.:|..:......|
Human   120 NEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQ-----ISYQHAAVHIPTDIYEGSTIV 179

  Fly   187 KSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRRFPGTAWPPEGSKGSKL-IHDFRTHNWF 250
            .:.|.|:..||.:|:.|.|:||:|.||.|||:||..|.:|.:.|.......:|: ::|.|...|:
Human   180 LNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWY 244

  Fly   251 VQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLGEDDFVNLITFSEVVKTPVPCFKDRM 315
            :|.|:||||::||:|.|.|::..:..|...:...:|:||.:|||||:.:|:...: .|.||: .:
Human   245 IQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQ-DVSCFQ-HL 307

  Fly   316 VRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHKYNQSGAGSQCNQAIMLITESTSESHK 380
            |:|...|.:.:|.||..|..:...::..|..:||..|..||.|.|  .||:.|||.|:...|..:
Human   308 VQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRA--NCNKIIMLFTDGGEERAQ 370

  Fly   381 DVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKGFFVQINDYDEARRKVIDYALVMARPM 445
            ::..:|| ....||:||:.:|..:..|..:..|||.|||::.:|......|....:|..|:.|||
Human   371 EIFNKYN-KDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPM 434

  Fly   446 IMY-QADHPVHWSPVFVAGKSGGLGRDSEYQRRLVTTVSTPVFDRRNHSVRVANL-----LGVVG 504
            ::. .....|.|:.|::.....|          ||.|.:.|||:.........||     |||:|
Human   435 VLAGDKAKQVQWTNVYLDALELG----------LVITGTLPVFNITGQFENKTNLKNQLILGVMG 489

  Fly   505 TDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLGDANQYIDQLKPKYASVDITELEL 569
            .||.:|:|:::.|:..|.||||.|.:|.||.||.||:|:|           ||  ..|.|..:.|
Human   490 VDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQP-----------KP--IGVGIPTINL 541

  Fly   570 ----PETEFGNNNEPI-------EINKNLLNEMRGDMIKPKEGETEFTVMNHYDDSKRVSTRTHR 623
                |..:...:.||:       |:..::..|:|..||..:.||..|..:....|.:.:......
Human   542 RKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRT 606

  Fly   624 YFYGPIEDTPFTLAIVLPE------KYGSHEFVSQQEIRHSRNNVTEYFKGDNWR------VHP- 675
            |.:.|:..|.::||:|||.      |....|.::|...:..:...:|..|.||:.      :.| 
Human   607 YTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARSKKGKMKDSETLKPDNFEESGYTFIAPR 671

  Fly   676 DWVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQPHH 740
            |  ||....:||      ::.|:.....|            |:.|             |:|    
Human   672 D--YCNDLKISD------NNTEFLLNFNE------------FIDR-------------KTP---- 699

  Fly   741 NMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDRNTTGSSSGKE 805
                     |.|.                     |:..|:..::.||..|:.|.:|....     
Human   700 ---------NNPS---------------------CNADLINRVLLDAGFTNELVQNYWSK----- 729

  Fly   806 DKHPIATLMAILKRQGYQKFV--VATSFVATRSGLLRWIDHVKRPEDTPEPHFSEDNVRAMDTSW 868
                             ||.:  |...||.|..|:.|     ..|::..|..  ::|....:.|:
Human   730 -----------------QKNIKGVKARFVVTDGGITR-----VYPKEAGENW--QENPETYEDSF 770

  Fly   869 YKRAIDQHSVEPDSFVYSVPF--GSGYAIKSNATLVTASHAIFVEHRGHKAAAGVVGLQFQHDSL 931
            |||::|.     |::|::.|:  .||.....:..:|:.:..|:::.:..|.|  |||::...:|.
Human   771 YKRSLDN-----DNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPA--VVGIKIDVNSW 828

  Fly   932 AKHF--INITSACTG-MTGCKRTCASDNLDCYVLDNSGFVIISEEMEHT---GKFFGQIDGTIMD 990
            .::|  .:|...|.| :..|||.  ||.:||.:||:.||::::...::|   |:|||:||.::|.
Human   829 IENFTKTSIRDPCAGPVCDCKRN--SDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMR 891

  Fly   991 SLVQDRIYKRVTVNDYQGVCSDADNPYTAAG-------GILKPNRLGSWFFNHLLALSAAW---- 1044
            .||...:|......|||.||.....|...||       .:....::|.|      |.:|||    
Human   892 HLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVADILQIGWW------ATAAAWSILQ 950

  Fly  1045 ---LSL-MPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVEY 1105
               ||| .|..|.|                                   |:.|.|:|  ||.:  
Human   951 QFLLSLTFPRLLEA-----------------------------------VEMEDDDF--TASL-- 976

  Fly  1106 TTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERPF 1170
                                 :.:.|......|....:..:..|        :.:|  ..|.|.|
Human   977 ---------------------SKQSCITEQTQYFFDNDSKSFSG--------VLDC--GNCSRIF 1010

  Fly  1171 SVQKIPHSNLILLVVDT--LCPCGSKQLDIEPLEEAGVIGACSTRRQGQEQESRRRPKKCINYHP 1233
            ..:|:.::|||.::|::  .|||.::.| |:..:.:.....|...:|   ...|:.|..|.:.:.
Human  1011 HGEKLMNTNLIFIMVESKGTCPCDTRLL-IQAEQTSDGPNPCDMVKQ---PRYRKGPDVCFDNNV 1071

  Fly  1234 EEIEIQQCGRGSTL 1247
            .| :...||..|.|
Human  1072 LE-DYTDCGGVSGL 1084

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4587NP_001188817.2 VWA_N 108..230 CDD:285584 31/134 (23%)
vWA_VGCC_like 245..428 CDD:238740 63/182 (35%)
Cache_1 456..544 CDD:280839 34/92 (37%)
VGCC_alpha2 590..>647 CDD:285647 17/62 (27%)
CACNA2D1XP_006716181.1 VWA_N 104..223 CDD:285584 31/134 (23%)
vWA_VGCC_like 239..417 CDD:238740 63/182 (35%)
Cache_1 446..536 CDD:280839 38/112 (34%)
VGCC_alpha2 562..646 CDD:285647 20/83 (24%)
RAMP_I_III <655..835 CDD:304371 54/282 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D69856at2759
OrthoFinder 1 1.000 - - FOG0000496
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10166
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X365
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
55.020

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