DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4587 and cacna2d4a

DIOPT Version :9

Sequence 1:	NP_001188817.2	Gene:	CG4587 / 34921	FlyBaseID:	FBgn0028863	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	XP_021330935.1	Gene:	cacna2d4a / 568225	ZFINID:	ZDB-GENE-041210-213	Length:	1105	Species:	Danio rerio

Alignment Length:	1263	Identity:	370/1263 - (29%)
Similarity:	585/1263 - (46%)	Gaps:	260/1263 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VRNWALKFGVDLWEFGRQFTKMNEIKSRFKDND--IEVKRKDGIILLRELAAEVKNFMDFKRNAV 101
            |:.||..||..|.....:::....::.::|:.:  ::::..||:.:::|.|.|::|.:..|..:|
Zfish    37 VQQWANNFGKQLMALSNRYSGAQLLQKKYKEVEPIVKMEEIDGLKMVKEFAEEMENMLGRKMKSV 101

  Fly   102 MRLMDSAEQA-------ALSELEGQGQAESPMGGQQHYDARRINEYNADGKLADGARHMDIRFMR 159
            .|:.::||.|       |..|.:             :|::..||..|.||...:......:....
Zfish   102 KRMAETAEDADFYHEFNATLEFD-------------YYNSMLINTLNEDGNNIELGGEFPLEENE 153

  Fly   160 RFERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRR 224
            .|..||||...|.:.||..|...:||:.:.:..|..|:.:|.:|.|:||.|:||||||||||.|.
Zfish   154 HFNNLPVNTQQSVVQVPTNVYNKDPDILNGVFMSEALNDIFISNFEKDPTLTWQYFGSSTGFFRL 218

  Fly   225 FPGTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTL 289
            :||..|.|:  :...:..|.|..||::|||:|||||:|.:|.|.||......:...|...|||||
Zfish   219 YPGIKWTPD--ENGVVTFDGRNRNWYIQAATSPKDIIIAVDISGSMKGLRLTIAKHTINTILDTL 281

  Fly   290 GEDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHK 354
            ||:||||:|.:|:.|:...||||..:|:|..||.:..|..|:.::::........::.:|.:|::
Zfish   282 GENDFVNVIAYSDYVQYVEPCFKGTLVQADLDNREHFKLLVQELQVKGEGKVKKAMKESFKILNE 346

  Fly   355 YNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKG 419
            ....|.||.|||||||||:...|..:.|.:::|||...||:||||||.:....||:..:||:|||
Zfish   347 AAAEGRGSLCNQAIMLITDGAMEDFQQVFEEFNWPDRKVRVFTYLIGRELTFASNVKWIACNNKG 411

  Fly   420 FFVQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVF---VAGKSGGLGRDSEYQRRLVTT 481
            ::..|:...:.:..|::|..|::|||:: ..||.:.|:..:   |...:..|.........|:|:
Zfish   412 YYTHISTLADVQENVMEYLHVLSRPMVI-NHDHDIIWTEAYMDSVLPNTAELFNTQAESLLLMTS 475

  Fly   482 VSTPVFDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLG 546
            |:.|||.::..::....||||||||||::|:.::.|::|||.:||:|:..|||.:|.|||||||
Zfish   476 VAMPVFSKKEETLSHGILLGVVGTDVPLKELMRLAPRYKLGVHGYAFLNTNNGYILSHPDLRPL- 539

  Fly   547 DANQYID--QLKPK--YASVDITELELPETEFGNNNEPIEINKNLLNEMRGDMIKPKEGETEFTV 607
                |.|  :||||  |.|||::|:|..:||               :.:|..|:|.:.|.....|
Zfish   540 ----YKDGKKLKPKPNYNSVDLSEVEWEDTE---------------DALRTAMVKGETGTISLDV 585

  Fly   608 MNHYDDSKRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVSQQEIRHSRNNVTEYFKGDNWR 672
            ....:..|||....:.|||..|.:|||:|.|||...:|.:.|:....:....:::|    ..:..
Zfish   586 RATVEKGKRVVFLKNEYFYTTINETPFSLGIVLTNGHGKNVFIGNVSVEEGLHDLT----ASDVS 646

  Fly   673 VHPDWVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQ 737
            :..:|.|||    :|::
Zfish   647 IAQEWTYCE----TDID------------------------------------------------ 659

  Fly   738 PHHNMHSGSNG------GNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDR- 795
            |||...:....      |..|...                   ||..|||..:.||:||..::.
Zfish   660 PHHRKLTQLQAVVRYLTGKEPDLE-------------------CDERLLQQTLFDAVVTAPMEAY 705

  Fly   796 ------NTTGSSSGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLRWIDHV---KRPEDT 851
                  |.:|...|                       |.|:|:.|||||:|.|.:.   ||....
Zfish   706 WTALLLNASGIDGG-----------------------VETAFLGTRSGLMRMIRYAGVEKRVAKK 747

  Fly   852 PEPHFSEDNVRAMD--TSWYKRAIDQHSVEPDSFVYSVPFGSGYAIKSNATLVTASHAIFVEHRG 914
            ......::|:..:|  ..||:||.:..:   ..|:|.||......:  |...|.|...:.|....
Zfish   748 FLTASDKENIFTLDHFPVWYRRAAENPA---GRFLYYVPTEDNSGV--NGRFVIAVTPVTVSVSK 807

  Fly   915 HKAAAGVVGLQFQHDSLAKHFINITSA-----CTGMTG-CKRTCASDNLD--CYVLDNSGFVIIS 971
            ..|.||.:|:|...:.|.|.|.:|.:.     |:|:.| |..:| |||.|  |||:|::||:|||
Zfish   808 KTAVAGAIGVQMSLEMLEKRFWSIANQPNDTDCSGIEGLCPLSC-SDNPDISCYVIDSNGFIIIS 871

  Fly   972 EEMEHTGKFFGQIDGTIMDSLVQDRIYKRVTVNDYQGVCSDADNPYTAAGGILKPNRLGSWFFNH 1036
            .:....|||.|:|:|::|..|::..::|||.:.|||.:|....:..:.|..:|.|      |:|.
Zfish   872 RDKADVGKFLGKIEGSVMSQLLKMGMFKRVVLYDYQAMCKAHAHSASGARPLLSP------FYNL 930

  Fly  1037 LLALSAAWLSLMPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTA 1101
            |.||.             |             |:.|......:|   |.||:.    ..:.||.|
Zfish   931 LAALK-------------W-------------FLSNFLFLLLDF---NIYNLW----HSDHFTEA 962

  Fly  1102 DVEYTTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLK--GKLTNCHVS 1164
            ...:.:...:.....:.|           ||.....::.:|.          :|  ..|..|  .
Zfish   963 KTSFHSSSKKLKGGFLQP-----------CDTEYPSFVYEPS----------IKETNSLIKC--G 1004

  Fly  1165 GCERPFSVQKIPHSNLILLVVDTLCPCGSKQ---LDIEPLE---EAGVIGACSTRRQGQEQESRR 1223
            .|::.|.:|:||.|||:|:|:...|.| |:|   :.:||.|   .|.|  .|...|   .|:.||
Zfish  1005 RCQKVFVIQQIPDSNLLLVVIQADCDC-SRQYPPITMEPKEVKYNASV--KCDRMR---SQKIRR 1063

  Fly  1224 RPKKCINYHPEEIEIQQCGRGSTLLHMS 1251
            ||:.|..|||:| ..:.|| |:..:.:|
Zfish  1064 RPESCHAYHPQE-NAKDCG-GAVAISLS 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	43/128 (34%)
		vWA_VGCC_like	245..428	CDD:238740	76/182 (42%)
		Cache_1	456..544	CDD:280839	35/90 (39%)
		VGCC_alpha2	590..>647	CDD:285647	20/56 (36%)
cacna2d4a	XP_021330935.1	VWA_N	114..224	CDD:312040	40/122 (33%)
		vWA_VGCC_like	237..420	CDD:238740	76/182 (42%)
		dCache_1	<472..576	CDD:308398	51/123 (41%)
		VGCC_alpha2	652..1032	CDD:312092	126/542 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H26544
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110668at33208
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm6553
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820