Protein Alignment stol and Cacna2d2

DIOPT Version :10

• Sequence 1: NP_001188817.2
• Gene: stol / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: XP_017168985.1
• Gene: Cacna2d2 / 56808
• MGIID: 1929813
• Length: 1160
• Species: Mus musculus
• Alignment Length: 1316
• Identity: 310/1316 - (23%)
• Similarity: 529/1316 - (40%)
• Gaps: 340/1316 - (25%)

  Fly    39 VRNWALKFGVDLWEFGRQFTKMNEIKSRFKDND--IEVKRKDGIILLRELAAEVKNFMDFKRNAV 101
            :::||.:...::....|.|..:.:::..:|||.  .||:..:...|:.::|.::::.:|.|..|:
Mouse    73 MQHWARRLEQEIDGVMRIFGGVQQLREIYKDNRNLFEVQENEPQKLVEKVAGDIESLLDRKVQAL 137

  Fly   102 MRLMDSAEQAALSELEGQGQAESPMGGQQHYDARRINEYNADGKLAD------------GARHMD 154
            .||.|:||....:........|..:   .:|||:      ||.:|.|            .|..:|
Mouse   138 KRLADAAENFQKAHRWQDNIKEEDI---MYYDAK------ADAELDDPESEDMERGSKTSALRLD 193

  Fly   155 IRFMRRFERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALSWQYFGSST 219
            ......|:. .||.|.:::.:|..:......:.:.|.|:..|:.:|..|..|||.|.||.|||:|
Mouse   194 FIEDPNFKN-KVNYSYTAVQIPTDIYKGSTVILNELNWTEALENVFIENRRQDPTLLWQVFGSAT 257

  Fly   220 GFLRRFPGTAWPPEGSKGSKLI--HDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATA 282
            |..|.:|.|.|     :..|.|  :|.|...|::|.||||||::|::|.|.|::..:..|...:.
Mouse   258 GVTRYYPATPW-----RAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSV 317

  Fly   283 FNILDTLGEDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQDTANFTAGLEY 347
            ..:||||.:||:||:.:|:|..: ||.|| ..:|:|...|.:..|.||:.:..:.|..:.||.||
Mouse   318 CEMLDTLSDDDYVNVASFNEKAQ-PVSCF-THLVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEY 380

  Fly   348 AFSLLHKYNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHD 412
            ||..|...|.:.|  .||:.||:.|:...:..:||.::||||:..||:||:.:|..:...:.|..
Mouse   381 AFDQLQNSNITRA--NCNKMIMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQW 443

  Fly   413 MACSNKGFFVQINDYDEARRKVIDYALVMARPMIMYQAD-HPVHWSPVFVAGKSGGLGRDSEYQR 476
            |||:|||::.:|......|....:|..|:.|||::...| ..|.|:.|:  ..:.|||
Mouse   444 MACTNKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKDAKQVQWTNVY--EDALGLG------- 499

  Fly   477 RLVTTVSTPVF--------DRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNN 533
             ||.|.:.|||        :::|..:     |||:|.||.:.:|:::.|.:.||.|||.|.:|.|
Mouse   500 -LVVTGTLPVFNLTQDGPGEKKNQLI-----LGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLN 558

  Fly   534 GRVLYHPDLRPLGDANQYIDQLKPKYASVDITELELPETEFGNNNEPIEINKNLLNEMRGDMIKP 598
            |.||.||:|:|  ..:|..:..:|  .::|..:.||.:    .|.|          |:|..||..
Mouse   559 GYVLLHPNLKP--QVSQTTNFREP--VTLDFLDAELED----ENKE----------EIRRSMIDG 605

  Fly   599 KEGETEFTVMNHYDDSKRVSTRTHRYFYGPIEDTPFTLAIVLP--EKYGSHEFVSQQ--EIRHSR 659
            .:|..:...:....|.:.:......|.:.||..|.::|.:|||  ..|.....:|.|  :::...
Mouse   606 DKGHKQIRTLVKSLDERYIDEVIRNYTWVPIRSTNYSLGLVLPPYSTYYLQANLSDQILQVKLPI 670

  Fly   660 NNVTEYFKGDNWRVHPDWVYCEYNSVSDLEKE-------RESSGEYSSRDQEPSFGSPEEQVLHF 717
            :.:.::               |:...|..|.|       ||...:.::.|....|      :.:|
Mouse   671 SKLKDF---------------EFLLPSSFESEGHVFIAPREYCKDLNASDNNTEF------LKNF 714

  Fly   718 LSRAGRPGWKWMSVRPKSPQPHHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQS 782
            :....:       |.|.|.|                                     |:..||.:
Mouse   715 IELMEK-------VTPDSKQ-------------------------------------CNNFLLHN 735

  Fly   783 LVRDAMVTDGLDRNTTGSSSGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLRWIDHVKR 847
            |:.|..:|..|                   :..:.:.|....:.:...|.||..|:.|...: |.
Mouse   736 LILDTGITQQL-------------------VERVWRDQDLNTYSLLAVFAATDGGITRVFPN-KA 780

  Fly   848 PED---TPEPHFSEDNVRAMDTSWYKRAIDQHSVEPDSFVYSVPFGSG----YAIKSNATLVTAS 905
            .||   .|||         .:.|:|:|::|.|     .:::..|....    ..::::...|..|
Mouse   781 AEDWTENPEP---------FNASFYRRSLDNH-----GYIFKPPHQDSLLRPLELENDTVGVLVS 831

  Fly   906 HAIFVEHRGHKAAAGVVGLQFQHDSLAKHFINITS----------ACTGMTGCKRTCASDNLD-- 958
            .|:.:..........|||::...::.|:.|..:.|          .|...:.|:..|..:|.|
Mouse   832 TAVELSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKQCGPSSHCEMDCEVNNEDLL 896

  Fly   959 CYVLDNSGFVIIS---EEMEHTGKFFGQIDGTIMDSLVQDRIYKRVTVNDYQGVCS--DADNPYT 1018
            |.::|:.||:::|   .:.:..|:||.::|..:|.:|..:..|.|....|||..|:  ...|...
Mouse   897 CVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGA 961

  Fly  1019 AAGGILKPN-----RLGSW-------FFNHLL--ALSAAWLSLMPASLRAWPQEEYTYDNEDVVF 1069
            |..|:..|.     .|..|       .|..||  .:..:|....||.....|:   |.::..|:
Mouse   962 APRGVFVPTIADFLNLAWWTSAAAWSLFQQLLYGLIYHSWFQADPAEAEGSPE---TRESSCVM- 1022

  Fly  1070 VDNNYSDEYEFGNEN-EYNMQVDQEMDEFFTTADVEYTTPPPRQHKPHVGPRFSPDPHNARRCDL 1133
                ...:|.||:.| .||..:|
Mouse  1023 ----KQTQYYFGSVNASYNAIID------------------------------------------ 1041

  Fly  1134 RTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERPFSVQKIPHSNLILLVV------------- 1185
                                       |  ..|.|.|..|::.::||:.:|.
Mouse  1042 ---------------------------C--GNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEAGRL 1077

  Fly  1186 ---DTLCPC-GSKQLDIEPLEEAGVIGACSTRRQGQEQESRRRPKKCINYHPEEIEIQQCGRGST 1246
               :|.||. |.:|.::.                 |....||.|..|.:|:..| :...||||::
Mouse  1078 LQKETHCPADGPEQCELV-----------------QRPRYRRGPHICFDYNATE-DTSDCGRGAS 1124

  Fly  1247 LLHMSGSVIVAHLLMV 1262
            .....|.::...||::
Mouse  1125 FPPSLGVLVSLQLLLL 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stol	NP_001188817.2	VWA_N	130..230	CDD:462464	33/111 (30%)
		vWA_VGCC_like	245..428	CDD:238740	68/182 (37%)
		PDC2_MCP_like	511..643	CDD:350337	38/133 (29%)
		VGCC_alpha2	810..>1048	CDD:462488	59/275 (21%)
Cacna2d2	XP_017168985.1	VWA_N	144..268	CDD:462464	36/133 (27%)
		vWA_VGCC_like	280..459	CDD:238740	68/182 (37%)
		HK_sensor	536..648	CDD:365792	36/129 (28%)
		VGCC_alpha2	675..1120	CDD:462488	111/640 (17%)