Protein Alignment CG4587 and cacna2d1a

DIOPT Version :9

• Sequence 1: NP_001188817.2
• Gene: CG4587 / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: XP_009298560.1
• Gene: cacna2d1a / 561434
• ZFINID: ZDB-GENE-041210-215
• Length: 1093
• Species: Danio rerio
• Alignment Length: 1275
• Identity: 311/1275 - (24%)
• Similarity: 537/1275 - (42%)
• Gaps: 292/1275 - (22%)

  Fly    40 RNWALKFGVDLWEFGRQFTKMNEIKSRFKD--NDIEVKRKDGIILLRELAAEVKNFMDFKRNAVM 102
            |.||.|...||.:.....:.:.|:|..|.:  ....|::.:...|:.:.:.|::.|:..:..|:.
Zfish    38 RKWAEKMQEDLVQLIDSESGIKELKKIFNNFQRHYTVRQNNPRQLVEKASHEIEEFLANRSKALE 102

  Fly   103 RLMDSAEQAALSELEGQGQAESPMGGQQHYDARRINE---YNADGKLADGARHMDIRFMRRFE-- 162
            .|..:||     .|:.:.|.:..:.         :||   |||..|..:.......|.:..|.
Zfish   103 ALATAAE-----NLQKEHQWKEDLD---------VNETIYYNAKDKSDNQTEPRKNRLILDFTED 153

  Fly   163 ---RLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRR 224
               :.||:.:.:::.:|..:......:.:.|.|:..||.:|:.|.|.||:|.||.|||:||..|.
Zfish   154 PAFKRPVSYNTTAVHIPTDIYEGSTIILNELNWTAALDDVFRKNKEDDPSLHWQVFGSATGLARY 218

  Fly   225 FPGTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTL 289
            ||.:.|  ..||....::|.|...|::|.|:||||::||:|||.|::..:..|...:...:|:||
Zfish   219 FPASPW--VDSKNKIDLYDVRRRPWYIQGAASPKDMLILVDASGSVSGLTLKLIRTSVSEMLETL 281

  Fly   290 GEDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHK 354
            .:||:||:::|:...|: |.|| :.:|:|...|.:.:|.||:.|....|.::..|.:.||:.|..
Zfish   282 SDDDYVNIVSFNNSAKS-VACF-ENLVQANVRNKKTLKEAVQKITANGTTDYKIGFKEAFNQLAS 344

  Fly   355 YNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKG 419
            .|.|.|  .||:.|||.|:...:...::..:|| ....|||||:.:|..:..::.:..|||.|||
Zfish   345 MNVSRA--NCNKIIMLFTDGGEDKASEIFDEYN-SDKRVRIFTFSVGQHNYDKAPIQYMACHNKG 406

  Fly   420 FFVQINDYDEARRKVIDYALVMARPMIMYQADHP---VHWSPVFVAGKSGGLGRDSEYQRRLVTT 481
            ::.:|......|....:|..|:.|||:  :||..   |.|:.|:|.....|          ||.|
Zfish   407 YYYEIPSIGAIRINTQEYLDVLGRPMV--KADKKAKNVQWTNVYVDALELG----------LVVT 459

  Fly   482 VSTPVFDRRNHSVRVAN---------LLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVL 537
            .:.|||::...|.....         :|||:..||.:::|:::.|.:.||||||.|.:|.||.||
Zfish   460 GTLPVFNKTRTSKEKPKGKNLGPSQMILGVMAIDVSLDDIKRLTPHYTLGPNGYYFAIDPNGYVL 524

  Fly   538 YHPDLRPLGDANQYIDQLKPKYASVDITELELPETEFGNNNEPIEINKNLLNEMRGDMIKPKEGE 602
            .||:|:|.       |....:..::|..:.|:        .:.:::      ::|..||..:..:
Zfish   525 LHPNLQPK-------DLKSQEPVTLDFLDAEM--------EDEVKV------DIRRSMIDGERSQ 568

  Fly   603 TEFTVMNHYDDSKRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVSQQEIRHSRNNVTEYFK 667
            ..|..:....|.:.:......|.:.|:.|..::||:|||:...|                  |.|
Zfish   569 IRFHTLMKSQDERYIDKGFRTYTWSPVTDADYSLALVLPDYSMS------------------YIK 615

  Fly   668 ---GDNWRVHPDWVYCEYNSVSD-LEKERESSGEY---SSRDQEPSFGSPEEQVLHFLSRAGRPG 725
               ||.......|: .|..:||: |:.::.....|   :.||......:..|.:..||....
Zfish   616 ATIGDTITQAKSWI-LENLAVSESLQVDKFEEYGYTLIAPRDYCEDLKAQNENMTQFLIDFN--- 676

  Fly   726 WKWMSVR-PKSPQPHHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMV 789
             :::.|: |..||                                     |:..|:..|:.||.:
Zfish   677 -EYIDVKTPNDPQ-------------------------------------CNMDLMNRLLLDAGI 703

  Fly   790 TDGLDRNTTGSSSGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLRWIDHVKRPEDTPEP 854
            |..|.::..                   |.|...:  :...||||..|:.|........|.|.:
Zfish   704 TAELVKHWN-------------------KNQLSDR--IKAKFVATDGGVTRVYPASAGSEWTGQ- 746

  Fly   855 HFSEDNVRAMDTSWYKRAIDQHSVEPDSFVYS-VPFGSGYAIKSNATLVTASHAIFVEHRGHKAA 918
                  ....::|:|||::|.     |.:|:: :||......:|  .||:.:..:.::....|.|
Zfish   747 ------AETYESSFYKRSLDN-----DLYVFTPLPFTGNKTEES--VLVSRAMDLRIDEFWLKPA 798

  Fly   919 AGVVGLQFQHDSLAKHFIN--ITSACTG-MTGCKRTCASDNLDCYVLDNSGFVIISEE---MEHT 977
              |||::....|..:.|:|  ||..|.| :.||:|.  .:.|||.:||:.||::::.:   ::..
Zfish   799 --VVGVKLDVQSWMESFMNTTITPKCEGEICGCRRN--DEYLDCVLLDDGGFLVMANQDKYIDQI 859

  Fly   978 GKFFGQIDGTIMDSLVQDRIYKRVTVNDYQGVCSDADNPYTAAG--GILKPN-----RLGSWFFN 1035
            |:|||.||.::|.:|:...::......|||.:|........|||  .:..|.     .:|.|
Zfish   860 GEFFGMIDPSLMRNLMNVSLFSVNITYDYQALCEPTRESKAAAGLRSVYVPTIADILNIGWW--- 921

  Fly  1036 HLLALSAAWLSLMPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQ---VDQEMDEF 1097
               |.:||| |:|        |:.:.    .:.|  .|:.:..:..:|:|...:   :.::...|
Zfish   922 ---ASAAAW-SIM--------QQLFV----SITF--PNFLEAVDISDESETPSKESCIKEQTQYF 968

  Fly  1098 FTTADVEYTTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCH 1162
            |.:.|..:                                                 ||.: :|
Zfish   969 FDSNDTTF-------------------------------------------------KGTV-DC- 982

  Fly  1163 VSGCERPFSVQKIPHSNLILLVVDT-LCP--CGSKQLDIEPLEEAGVIGACSTRRQGQEQESRRR 1224
             ..|.|.|..:|:..:||:|:|.|| :|.  |..|....|.....|. ..|..   .|....|:.
Zfish   983 -QNCSRQFIAEKLMKTNLVLIVADTEMCSQMCEEKPFSQEEKPSPGP-DPCLI---SQNPRYRKG 1042

  Fly  1225 PKKCI--NYHPEEIEIQQCGRGSTLLHMSGSVIVAHLLMV 1262
            |.:|.  |.:.|.:    |.|.      :||.:::.|||:
Zfish  1043 PMECFDNNVNDEAM----CRRN------AGSPLLSSLLML 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	35/129 (27%)
		vWA_VGCC_like	245..428	CDD:238740	63/182 (35%)
		Cache_1	456..544	CDD:280839	33/96 (34%)
		VGCC_alpha2	590..>647	CDD:285647	13/56 (23%)
cacna2d1a	XP_009298560.1	VWA_N	110..224	CDD:285584	33/122 (27%)
		vWFA	237..415	CDD:294047	63/182 (35%)
		Cache_1	444..532	CDD:280839	33/97 (34%)
		VGCC_alpha2	545..627	CDD:285647	19/113 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010