DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4587 and CACNA2D3

DIOPT Version :9

Sequence 1:	NP_001188817.2	Gene:	CG4587 / 34921	FlyBaseID:	FBgn0028863	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_060868.2	Gene:	CACNA2D3 / 55799	HGNCID:	15460	Length:	1091	Species:	Homo sapiens

Alignment Length:	1288	Identity:	371/1288 - (28%)
Similarity:	598/1288 - (46%)	Gaps:	270/1288 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 IFVAFAD---QDEDIPHNEVRNWALKFGVDLWEFGRQFTKMNEIKSRFK--DNDIEVKRKDGIIL 82
            ::.|..|   .::.||.:.|:.||..||.::.....:::....::.::|  :.|:.::..||:.|
Human    23 LYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQL 87

  Fly    83 LRELAAEVKNFMDFKRNAVMRLMDSAEQAALS-ELEGQGQAESPMGGQQHYDARRINEYNADGKL 146
            :::||..::.....|..||.||:::||:|.|. |.:...|.|       :::|..|||.:.||..
Human    88 VKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYE-------YFNAVLINERDKDGNF 145

  Fly   147 ADGARHMDIRFMRRFERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALS 211
            .:..:...:.....|..||||:|||.:.||..:...:|.:.:.:.||..|:.:|.:|.::||:|.
Human   146 LELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLI 210

  Fly   212 WQYFGSSTGFLRRFPGTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFD 276
            ||||||:.||.|::||..|.|:  :...:..|.|...|::|||:||||::||:|.|.||......
Human   211 WQYFGSAKGFFRQYPGIKWEPD--ENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLT 273

  Fly   277 LGMATAFNILDTLGEDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEI-----KSAVKAIKLQ 336
            :...|..:||||||:|||.|:|.::|.:....||....:|:|...|.:..     |...|.|.:.
Human   274 IAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGML 338

  Fly   337 DTANFTAGLEYAFSLLHKYNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIG 401
            |.|     |..||::|..:|.:|.||.|:|||||||:...:::..:..:||||...|||||||||
Human   339 DIA-----LNEAFNILSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPDRKVRIFTYLIG 398

  Fly   402 SDSGSRSNLHDMACSNKGFFVQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVFVAGKSG 466
            .::....||..|||:|||||.||:...:.:..|::|..|::||.::.| :|.|.|:..::
Human   399 REAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQ-EHDVVWTEAYI----- 457

  Fly   467 GLGRDSEYQRR----------LVTTVSTPVFDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKL 521
                ||...:.          |:|||:.|||.::|.:.....||||||||||::|:.|.||::||
Human   458 ----DSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKL 518

  Fly   522 GPNGYSFIVDNNGRVLYHPDLRPLGDANQYIDQLKPKYASVDITELELPETEFGNNNEPIEINKN 586
            |.:||:|.:.|||.:|.||:||.|.:..:  .:.||.|:|||::|:|..:.:
Human   519 GIHGYAFAITNNGYILTHPELRLLYEEGK--KRRKPNYSSVDLSEVEWEDRD------------- 568

  Fly   587 LLNEMRGDMIKPKEGETEFTVMNHYDDSKRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVS 651
              :.:|..|:..|.|:....|....|..|||...|:.|:|..|:.|||:|.:.|...:|.:.|
Human   569 --DVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGTPFSLGVALSRGHGKYFF-- 629

  Fly   652 QQEIRHSRNNVTEYFKGDNWRVHPD------WVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSP 710
                   |.||| ..:|.:...|||      |.||.    :||
Human   630 -------RGNVT-IEEGLHDLEHPDVSLADEWSYCN----TDL---------------------- 660

  Fly   711 EEQVLHFLSRAGRPGWKWMSVRPKSPQPHHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYF- 774
                                      .|.|.              |...........:..||..
Human   661 --------------------------HPEHR--------------HLSQLEAIKLYLKGKEPLLQ 685

  Fly   775 CDRALLQSLVRDAMVTDGLDRNTTGSSSGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLL 839
            ||:.|:|.::.||:|:..::...|.              :|:.|.:...| .|..:|:.||:||.
Human   686 CDKELIQEVLFDAVVSAPIEAYWTS--------------LALNKSENSDK-GVEVAFLGTRTGLS 735

  Fly   840 RWIDHVKRPEDTPEPHFSEDNVRAMDTS----------WYKRAIDQHSVEPDSFVYSVPFGSGYA 894
            |....|...:.|     ::|.::|.|..          ||:||.:|   .|.|||||:||.:|..
Human   736 RINLFVGAEQLT-----NQDFLKAGDKENIFNADHFPLWYRRAAEQ---IPGSFVYSIPFSTGPV 792

  Fly   895 IKSNATLVTASHAIFVEHRGHKAAAGVVGLQFQHDSLAKHFINITSACTGMTG-CKRTCASDNLD 958
            .|||  :||||.:|.:...........||:|.:.:...:.|...:..|..:.| |..:|..:.::
Human   793 NKSN--VVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVN 855

  Fly   959 CYVLDNSGFVIISEEMEHTGKFFGQIDGTIMDSLVQDRIYKRVTVNDYQGVCSDADNPYTAAGGI 1023
            ||::||:||:::||:...||.|||:|:|.:|:.|:....:||:|:.|||.:|.........|.|:
Human   856 CYLIDNNGFILVSEDYTQTGDFFGEIEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDGAHGL 920

  Fly  1024 LKPNRLGSWFFNHLLALSAAW------LSLMPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGN 1082
            |.|       :|..|: :..|      |.|:..:|.:|...:.|
Human   921 LDP-------YNAFLS-AVKWIMTELVLFLVEFNLCSWWHSDMT--------------------- 956

  Fly  1083 ENEYNMQVDQEMDEFFTTADVEYTTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQ 1147
                  ...|::.:.....|.||             |.|..:         ||
Human   957 ------AKAQKLKQTLEPCDTEY-------------PAFVSE---------RT------------ 981

  Fly  1148 GGQNNPLKGKLTNCHVSGCERPFSVQKIPHSNLILLVVDTLCPCGSKQLDIEPLEEAGV---IGA 1209
                  :|....|.....|.:.|.:|:||.|||.::|||:.|.|.|    :.|:..|.:   ...
Human   982 ------IKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCES----VAPITMAPIEIRYNE 1036

  Fly  1210 CSTRRQGQEQESRRRPKKCINYHPEEIEIQQCGRGSTLLHMSGSVIVAHLLMV 1262
            .....:.:.|:.||||:.|..:|||| ..::||...:|...:..:::..|||:
Human  1037 SLKCERLKAQKIRRRPESCHGFHPEE-NARECGGAPSLQAQTVLLLLPLLLML 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	43/122 (35%)
		vWA_VGCC_like	245..428	CDD:238740	79/187 (42%)
		Cache_1	456..544	CDD:280839	38/97 (39%)
		VGCC_alpha2	590..>647	CDD:285647	19/56 (34%)
CACNA2D3	NP_060868.2	VWA_N	113..229	CDD:369855	43/122 (35%)
		vWA_VGCC_like	242..425	CDD:238740	79/187 (42%)
		MIDAS-like motif	262..266		2/3 (67%)
		dCache_1	<442..552	CDD:376917	43/121 (36%)
		PDC2_MCP_like	508..622	CDD:350337	45/130 (35%)
		VGCC_alpha2	655..1068	CDD:369894	134/583 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5480
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	573	1.000	Inparanoid score	I1047
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110668at33208
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm8612
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	O	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.970