DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4587 and cacna2d2a

DIOPT Version :9

Sequence 1:	NP_001188817.2	Gene:	CG4587 / 34921	FlyBaseID:	FBgn0028863	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	NP_001013521.3	Gene:	cacna2d2a / 541376	ZFINID:	ZDB-GENE-050320-71	Length:	1109	Species:	Danio rerio

Alignment Length:	1301	Identity:	323/1301 - (24%)
Similarity:	546/1301 - (41%)	Gaps:	308/1301 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 HNEVRNWALKFGVDLWEFGRQFTKMNEIKSRFKD--NDIEVKRKDGIILLRELAAEVKNFMDFKR 98
            |..:.:||.:...:|.:..:..|...::::.:.|  |..:|.|.....|:.::|.::...::.||
Zfish    37 HYTMMHWAGRIEKELEKVLQLVTGGQQMRAIYNDKRNQFDVVRNTPKQLVEKVAGDIAKLLNRKR 101

  Fly    99 NAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYDARRINEY--NADGK-LADGARHMDIRFM-- 158
            .|:.||...||..   :.|...|........|:|||:..::.  :.||: |.|....:.:.|:
Zfish   102 KALERLAREAEDI---QREHSWQDAIKENDIQYYDAKADSDVMDDDDGENLLDNPNSLSLEFVDD 163

  Fly   159 RRFERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLR 223
            ..|:. .||.|.:::.:|..:....|.:.:.|.|:..|:.:|..|..:||:|.||.|||:||..|
Zfish   164 PNFKN-KVNYSYTAVQIPTDIYKGSPTILNELNWTQSLERVFIENSREDPSLRWQVFGSTTGVTR 227

  Fly   224 RFPGTAWPPEGSKGSKL-IHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILD 287
            .:|.|.|    ...:|: ::|.|...|::|.||||||::|::|.|.|::..:..|...:...:||
Zfish   228 YYPATKW----KAPNKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVIEMLD 288

  Fly   288 TLGEDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLL 352
            ||.:||:||:..|:|.....|||| ..:|:|...|.:..|.||..::.:.|.::..|.::||..|
Zfish   289 TLSDDDYVNVARFNEKAYAVVPCF-TTLVQANIKNKKIFKEAVMNMQAKGTTDYKTGFQFAFDQL 352

  Fly   353 HKYNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSN 417
            .. :.|...:.||:.||:.|:...:..:|:.::||||:..||:||:.:|..:...:.|..:||.|
Zfish   353 LN-DTSAPRANCNKMIMMFTDGGEDRAQDIFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWIACFN 416

  Fly   418 KGFFVQINDYDEARRKVIDYALVMARPMIMY-QADHPVHWSPVFVAGKSGGLGRDSEYQRRLVTT 481
            ||::.:|......|....:|..|:.|||::. :....|.|:.|:  ..:.|||        ||.|
Zfish   417 KGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGERAKQVQWTNVY--QDALGLG--------LVIT 471

  Fly   482 VSTPVF----DRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDL 542
            .:.|||    ||.....::  :|||:|.|:.:.||:::.|::|||.|||:|.:|.||.||.||:|
Zfish   472 GTMPVFNLTADRDTKQNQL--MLGVMGVDIALNEIKELTPRYKLGANGYTFAIDPNGYVLLHPNL 534

  Fly   543 RPLGDANQYIDQLKPKYASVDITELELPETEFGNNNEPIEINKNLLNEMRGDMIKPKEGETEFTV 607
            :|     :.|:..:|  .::|..:.|||:    .|.|          |:|..||..:.|:.:...
Zfish   535 QP-----KIINFREP--VTLDFLDAELPD----RNKE----------EIRRQMIDGRGGQRKIKT 578

  Fly   608 MNHYDDSKRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVSQQEIRHSRNNVTEYFKGDNWR 672
            :....|.:.:......|.:.|:|.|.::|.:|||         |..| .|.|.|:::..
Zfish   579 LVKSVDERYIDESQRTYIWSPVEGTDYSLGLVLP---------SYSE-NHIRANLSDQI------ 627

  Fly   673 VHPDWVYCEYNS-----VSDLEKERESSG-------EYSSRDQEPSFGSPEEQVLHFLSRAGRPG 725
                 :..:|.|     .|.|....||.|       || .:|.|.| .:..|.:|:|::...:
Zfish   628 -----LQVQYGSDFKDFESLLPNTFESEGHVFIAPREY-CKDLELS-NNNTEFLLNFIALMEK-- 683

  Fly   726 WKWMSVRPKSPQPHHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVT 790
                 |.|.|.|                                     ||..||.:|:.|..:.
Zfish   684 -----VTPDSKQ-------------------------------------CDNFLLHNLILDTGII 706

  Fly   791 DGL--------DRNTTGSSSGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLR------- 840
            ..|        |.||.|             .:|:              |.||..|:.|
Zfish   707 KQLVDRVWKINDLNTYG-------------FLAV--------------FAATDGGITRVFPNKAA 744

  Fly   841 --WIDHVKRPEDTPEPHFSEDNVRAMDTSWYKRAIDQHSVEPDSFVYSVPF---GSGYAIKSNAT 900
              |       |:..||         .:.|:|:|::|.     ..:::..|:   ........|.|
Zfish   745 ETW-------EEDSEP---------FNASYYRRSLDN-----KGYIFRAPYRTANDDIMNPENDT 788

  Fly   901 L-VTASHAIFVEHRGHKAAAGVVGLQFQHDSLAKHFINITS-----------ACTGMTGCKRTCA 953
            : :..|.|:.:..........|||::...::....|..:.|           .|...:||:..|.
Zfish   789 IGILVSTAVDITMGSRNLKPAVVGVKLDLEAWTDKFKILASNHTDSNRLSSQTCGPTSGCEMDCE 853

  Fly   954 --SDNLDCYVLDNSGFVIISEEMEH---TGKFFGQIDGTIMDSLVQDRIYKRVTVNDYQGVCSDA 1013
              ||:|.||::|:.||:|:|.:.:|   .|.||.::|.|:..:|..:..|:|....|||.||...
Zfish   854 ANSDDLLCYLIDDGGFLIMSNQKDHWYKIGMFFSEVDPTLFYALYNNSFYRRKQSFDYQSVCDPV 918

  Fly  1014 DNPYTAAG--GILKPNRLGSWFFNHLLA--LSAAWLSLMPASLRAW---PQEEYTYDNEDVVFVD 1071
            .:..|.|.  |:..|.          :|  |:.|||:    |..||   .|..|.:..:.....|
Zfish   919 PSSNTGAAPRGVFVPT----------IADMLNVAWLT----SAAAWSLLQQMLYGFAYQSWFMTD 969

  Fly  1072 NNYSDEYEFGNENEYNMQVDQEMDEFFTTADVEYTTPPPRQHKPHVGPRFSPDPHNARRCDLRTD 1136
                             :||.|..|:..|:.|                            .::|.
Zfish   970 -----------------EVDAEGFEYKETSCV----------------------------TVQTQ 989

  Fly  1137 LYMLQPERLNQGGQNNPLKGKLTNCHVSGCERPFSVQKIPHSNLILLVVDTLCPCGSKQLDIEPL 1201
            .|.     .|.....|.|:    :|  ..|.|....::|.::||:.:|.:.| .|.|  .:||.|
Zfish   990 FYF-----SNISSSYNILQ----DC--DNCSRLIHAKRINNTNLLFVVAERL-SCNS--CEIEKL 1040

  Fly  1202 EEAGV----IGACSTRRQGQEQESRRRPKKCINYHPEEIEIQQCGRGSTLLHMSGSVIVAHLLMV 1262
            .:...    ..||.|.   .....|:....|.:|...| ....||||.:......::::..||::
Zfish  1041 SQVETEYKETKACETI---AAPRYRKGTTSCFDYSVLE-NTSDCGRGHSFRPSLYTLLLLQLLLL 1101

  Fly  1263 T 1263
            :
Zfish  1102 S 1102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	37/126 (29%)
		vWA_VGCC_like	245..428	CDD:238740	62/182 (34%)
		Cache_1	456..544	CDD:280839	36/91 (40%)
		VGCC_alpha2	590..>647	CDD:285647	14/56 (25%)
cacna2d2a	NP_001013521.3	VWA_N	111..234	CDD:369855	37/126 (29%)
		vWA_VGCC_like	246..427	CDD:238740	62/182 (34%)
		HK_sensor	503..616	CDD:365792	42/142 (30%)
		VGCC_alpha2	638..1081	CDD:369894	126/613 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910