Protein Alignment stol and Cacna2d4

DIOPT Version :10

• Sequence 1: NP_001188817.2
• Gene: stol / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: NP_001028554.3
• Gene: Cacna2d4 / 319734
• MGIID: 2442632
• Length: 1116
• Species: Mus musculus
• Alignment Length: 1246
• Identity: 362/1246 - (29%)
• Similarity: 581/1246 - (46%)
• Gaps: 214/1246 - (17%)

  Fly    34 IPHNEVRNWALKFGVDLWEFGRQFTKMNEIKSRFKDND--IEVKRKDGIILLRELAAEVKNFMDF 96
            :|...|:.||..||.:|:....:::....::.::||.:  :::|..||:.|:::.:.:::..:..
Mouse    51 VPLETVKLWADTFGRNLYNTVTRYSGSLLLQKKYKDAEPSLKIKEVDGLELVKKFSEDMETMLRR 115

  Fly    97 KRNAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYDARRINEYNADGKLADGARHMDIRFMRRF 161
            |..||..|:::||:|   :|..:..|....   .:|::..|||.:..|...:......:.....|
Mouse   116 KVEAVESLVEAAEEA---DLNHEFNASLVF---NYYNSVLINEKDDKGNYVELGAEFLLESDAHF 174

  Fly   162 ERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRRFP 226
            ..|.||:|:||:.:|..|...:||:.:.:..|..|:|:|..|.::||.|:||||||||||.|.:|
Mouse   175 SNLRVNVSMSSVQLPTNVYNKDPDILNGVYMSEALNPVFVENFQRDPTLTWQYFGSSTGFFRIYP 239

  Fly   227 GTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLGE 291
            |..|.|:  :...:..|.|...|::|||:|||||:||:|.|.||......:...|...|||||||
Mouse   240 GIKWMPD--ENGVIAFDCRNRGWYIQAATSPKDIVILVDISGSMKGLRMAIAKHTITTILDTLGE 302

  Fly   292 DDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHKYN 356
            :||||:|.:::.|....||||..:|:|..||.:..|..|..:.::.....:..|..||.:|.::.
Mouse   303 NDFVNIIAYNDYVHYIEPCFKGILVQADRDNREHFKQLVDELMVKGVGVVSQALIEAFEILKQFQ 367

  Fly   357 QSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKGFF 421
            :|..||.|||||||||:...|.::.|.:.||||...||:||||||.:......:..:||:|||::
Mouse   368 ESKQGSLCNQAIMLITDGAVEDYEPVFETYNWPDRKVRVFTYLIGREVTFADRMKWIACNNKGYY 432

  Fly   422 VQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVFVAGKSGGLGRDSEYQRRLVTTVSTPV 486
            .||:...:|:..|::|..|::|||:: ..||.:.|:..::..:   |.........|:|||:.||
Mouse   433 TQISTLADAQESVMEYLHVLSRPMVI-NHDHDIIWTEAYMDSR---LFTSEAQSLMLLTTVAMPV 493

  Fly   487 FDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLGDANQY 551
            |.::|.:.....||||||:||.:.|:.|:.|::|||.:||:|:..|||.:|.|||||||....:.
Mouse   494 FSKKNETRSHGILLGVVGSDVTLRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKK 558

  Fly   552 IDQLKPKYASVDITELELPETEFGNNNEPIEINKNLLNEMRGDMIKPKEGETEFTVMNHYDDSKR 616
            : :.||.|.|||::|:|.        .:..||       :|..||..:.|.....|....|..||
Mouse   559 L-RPKPNYNSVDLSEVEW--------EDQAEI-------LRTAMINGETGSHSMDVKVPLDKGKR 607

  Fly   617 VSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVSQQEIRHSRNNVTEYFKGDNWRVHP------ 675
            |...|:.||:..|.||||:|.:||...:|.:..:....:....:::          :||
Mouse   608 VLFLTNDYFFTDISDTPFSLGVVLTRGHGEYILLGNTSVEEGLHDL----------LHPDLTLAS 662

  Fly   676 DWVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQPHH 740
            ||:||    ::|::.:.....:.             |.|:.||:
Mouse   663 DWIYC----ITDIDPDHRKLSQL-------------EAVVRFLT--------------------- 689

  Fly   741 NMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDRNTTGSSSG-K 804
                    |..|...                   ||..|::.::.||:||..::...|..:.. .
Mouse   690 --------GVDPDLE-------------------CDEELVREVLFDAVVTAPMEAYWTALALNIS 727

  Fly   805 EDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLR---WIDHVK---RPEDTPEPHFSEDNVRA 863
            |:..|                .|..:|:.||:||||   ::...|   |...|||   .|.::..
Mouse   728 EESEP----------------GVDVAFLGTRAGLLRRSLFVGSEKVSDRKFLTPE---DEASIFT 773

  Fly   864 MD--TSWYKRAIDQHSVEPDSFVYSVPFGSGYAIKSNATLVTASHAIFVEHRGHKAAAGVVGLQF 926
            ||  ..||::|.:|   .|.|||:::.:..|.........|.||.|:.|...|..|.|..||:|.
Mouse   774 MDHFPLWYRQASEQ---PPGSFVFNLRWAEGPDSPGKPVAVRASTAVTVTVDGKTAIAAAVGIQM 835

  Fly   927 QHDSLAKHFINITSACTGMTG-CKRTCASDNLDCYVLDNSGFVIISEEMEHTGKFFGQIDGTIMD 990
            |.|.|.:.|......|..:.| |.::|...:|||:|:||:|||:|||..:..|:..|:.||.:|.
Mouse   836 QADYLQRQFWAAMQQCNAVEGPCLKSCEDTDLDCFVIDNNGFVLISERPQEMGRLLGEADGALMK 900

  Fly   991 SLVQDRIYKRVTVNDYQGVCSDADNPYTAAGGILKP----NRLGSWFFNHLLALSAAWLSLMPAS 1051
            .|:...::.|||:.|||.:|...|:.::||..:..|    ..:..|..:..|.....|
Mouse   901 QLLSMGVFSRVTMYDYQAMCKPPDHHHSAAESLFSPLSAFLMVARWLLHECLLFLLEW------- 958

  Fly  1052 LRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVEYTTPPPRQHKPH 1116
             .||                .::.|:   |:|.:....                     ..||..
Mouse   959 -SAW----------------GSWQDK---GSEAKSVFH---------------------HSHKHK 982

  Fly  1117 VGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERPFSVQKIPHSNLI 1181
            ......|       ||....:::.|.......|        :..|  .||::.|.:|:||.|||:
Mouse   983 KQDLLHP-------CDTEYPVFVHQTAIQEANG--------IIEC--GGCQKTFVMQQIPRSNLL 1030

  Fly  1182 LLVVDTLCPCGSKQLDIEPLEEAGVIGACSTRRQGQEQESRRRPKKCINYHPEEIEIQQCGRGST 1246
            |||.|..|.|.:....::...|.....:....|. :.|:.||||..|..:|||| ..|.||..|.
Mouse  1031 LLVTDRTCDCSAHSPILQEATEVKYNASVKCDRM-RSQKPRRRPGSCHAFHPEE-NAQDCGGASD 1093

  Fly  1247 LLHMSGSVIVA 1257
            .|..|..::::
Mouse  1094 TLPSSPLLLLS 1104

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stol	NP_001188817.2	VWA_N	130..230	CDD:462464	37/99 (37%)
		vWA_VGCC_like	245..428	CDD:238740	77/182 (42%)
		PDC2_MCP_like	511..643	CDD:350337	50/131 (38%)
		VGCC_alpha2	810..>1048	CDD:462488	76/250 (30%)
Cacna2d4	NP_001028554.3	VWA_N	127..243	CDD:462464	42/121 (35%)
		vWA_VGCC_like	256..439	CDD:238740	77/182 (42%)
		MIDAS-like motif	276..280		2/3 (67%)
		HK_sensor	<463..516	CDD:365792	18/55 (33%)
		HK_sensor	518..631	CDD:365792	48/128 (38%)
		VGCC_alpha2	640..1089	CDD:462488	140/612 (23%)