DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4587 and Cacna2d4

DIOPT Version :9

Sequence 1:	NP_001188817.2	Gene:	CG4587 / 34921	FlyBaseID:	FBgn0028863	Length:	1271	Species:	Drosophila melanogaster
Sequence 2:	XP_036022112.1	Gene:	Cacna2d4 / 319734	MGIID:	2442632	Length:	1137	Species:	Mus musculus

Alignment Length:	1246	Identity:	362/1246 - (29%)
Similarity:	580/1246 - (46%)	Gaps:	221/1246 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IPHNEVRNWALKFGVDLWEFGRQFTKMNEIKSRFKDND--IEVKRKDGIILLRELAAEVKNFMDF 96
            :|...|:.||..||.:|:....:::....::.::||.:  :::|..||:.|:::.:.:::..:..
Mouse    79 VPLETVKLWADTFGRNLYNTVTRYSGSLLLQKKYKDAEPSLKIKEVDGLELVKKFSEDMETMLRR 143

  Fly    97 KRNAVMRLMDSAEQAALSELEGQGQAESPMGGQQHYDARRINEYNADGKLADGARHMDIRFMRRF 161
            |..||..|:::||:|   :|..:..|....   .:|::..|||.:..|...:......:.....|
Mouse   144 KVEAVESLVEAAEEA---DLNHEFNASLVF---NYYNSVLINEKDDKGNYVELGAEFLLESDAHF 202

  Fly   162 ERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRRFP 226
            ..|.||:|:||:.:|..|...:||:.:.:..|..|:|:|..|.::||.|:||||||||||.|.:|
Mouse   203 SNLRVNVSMSSVQLPTNVYNKDPDILNGVYMSEALNPVFVENFQRDPTLTWQYFGSSTGFFRIYP 267

  Fly   227 GTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLGE 291
            |..|.|:  :...:..|.|...|::|||:|||||:||:|.|.||......:...|...|||||||
Mouse   268 GIKWMPD--ENGVIAFDCRNRGWYIQAATSPKDIVILVDISGSMKGLRMAIAKHTITTILDTLGE 330

  Fly   292 DDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLLHKYN 356
            :||||:|.:::.|....||||..:|:|..||.:..|..|..:.::.....:..|..||.:|.::.
Mouse   331 NDFVNIIAYNDYVHYIEPCFKGILVQADRDNREHFKQLVDELMVKGVGVVSQALIEAFEILKQFQ 395

  Fly   357 QSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIGSDSGSRSNLHDMACSNKGFF 421
            :|..||.|||||||||:...|.::.|.:.||||...||:||||||.:......:..:||:|||::
Mouse   396 ESKQGSLCNQAIMLITDGAVEDYEPVFETYNWPDRKVRVFTYLIGREVTFADRMKWIACNNKGYY 460

  Fly   422 VQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVFVAGKSGGLGRDSEYQRRLVTTVSTPV 486
            .||:...:|:..|::|..|::|||:: ..||.:.|:..::..:   |.........|:|||:.||
Mouse   461 TQISTLADAQESVMEYLHVLSRPMVI-NHDHDIIWTEAYMDSR---LFTSEAQSLMLLTTVAMPV 521

  Fly   487 FDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLGDANQY 551
            |.::|.:.....||||||:||.:.|:.|:.|::|||.:||:|:..|||.:|.|||||||....:.
Mouse   522 FSKKNETRSHGILLGVVGSDVTLRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKK 586

  Fly   552 IDQLKPKYASVDITELELPETEFGNNNEPIEINKNLLNEMRGDMIKPKEGETEFTVMNHYDDSKR 616
            : :.||.|.|||::|:|.        .:..||       :|..||..:.|.....|....|..||
Mouse   587 L-RPKPNYNSVDLSEVEW--------EDQAEI-------LRTAMINGETGSHSMDVKVPLDKGKR 635

  Fly   617 VSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVSQQEIRHSRNNVTEYFKGDNWRVHP------ 675
            |...|:.||:..|.||||:|.:||...:|.:..:....:....:::          :||
Mouse   636 VLFLTNDYFFTDISDTPFSLGVVLTRGHGEYILLGNTSVEEGLHDL----------LHPDLTLAS 690

  Fly   676 DWVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKWMSVRPKSPQPHH 740
            ||:||    ::|::.:.....:.             |.|:.||:
Mouse   691 DWIYC----ITDIDPDHRKLSQL-------------EAVVRFLT--------------------- 717

  Fly   741 NMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCDRALLQSLVRDAMVTDGLDRNTTGSSSG-K 804
                    |..|...                   ||..|::.::.||:||..::...|..:.. .
Mouse   718 --------GVDPDLE-------------------CDEELVREVLFDAVVTAPMEAYWTALALNIS 755

  Fly   805 EDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLR---WIDHVK---RPEDTPEPHFSEDNVRA 863
            |:..|                .|..:|:.||:||||   ::...|   |...|||   .|.::..
Mouse   756 EESEP----------------GVDVAFLGTRAGLLRRSLFVGSEKVSDRKFLTPE---DEASIFT 801

  Fly   864 MD--TSWYKRAIDQHSVEPDSFVYSVPFGSGYAIKSNATLVTASHAIFVEHRGHKAAAGVVGLQF 926
            ||  ..||::|.:|   .|.|||:::.:..|.........|.||.|:.|...|..|.|..||:|.
Mouse   802 MDHFPLWYRQASEQ---PPGSFVFNLRWAEGPDSPGKPVAVRASTAVTVTVDGKTAIAAAVGIQM 863

  Fly   927 QHDSLAKHFINITSACTGMTG-CKRTCASDNLDCYVLDNSGFVIISEEMEHTGKFFGQIDGTIMD 990
            |.|.|.:.|......|..:.| |.::|...:|||:|:||:|||:|||..:..|:..|:.||.:|.
Mouse   864 QADYLQRQFWAAMQQCNAVEGPCLKSCEDTDLDCFVIDNNGFVLISERPQEMGRLLGEADGALMK 928

  Fly   991 SLVQDRIYKRVTVNDYQGVCSDADNPYTAAGGILKP----NRLGSWFFNHLLALSAAWLSLMPAS 1051
            .|:...::.|||:.|||.:|...|:.::||..:..|    ..:..|..:..|.....|
Mouse   929 QLLSMGVFSRVTMYDYQAMCKPPDHHHSAAESLFSPLSAFLMVARWLLHECLLFLLEW------- 986

  Fly  1052 LRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVEYTTPPPRQHKPH 1116
             .||                .::.|:   |:|                            .||..
Mouse   987 -SAW----------------GSWQDK---GSE----------------------------AHKHK 1003

  Fly  1117 VGPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTNCHVSGCERPFSVQKIPHSNLI 1181
            ......|       ||....:::.|.......|        :..|  .||::.|.:|:||.|||:
Mouse  1004 KQDLLHP-------CDTEYPVFVHQTAIQEANG--------IIEC--GGCQKTFVMQQIPRSNLL 1051

  Fly  1182 LLVVDTLCPCGSKQLDIEPLEEAGVIGACSTRRQGQEQESRRRPKKCINYHPEEIEIQQCGRGST 1246
            |||.|..|.|.:....::...|.....:....|. :.|:.||||..|..:|||| ..|.||..|.
Mouse  1052 LLVTDRTCDCSAHSPILQEATEVKYNASVKCDRM-RSQKPRRRPGSCHAFHPEE-NAQDCGGASD 1114

  Fly  1247 LLHMSGSVIVA 1257
            .|..|..::::
Mouse  1115 TLPSSPLLLLS 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4587	NP_001188817.2	VWA_N	108..230	CDD:285584	42/121 (35%)
		vWA_VGCC_like	245..428	CDD:238740	77/182 (42%)
		Cache_1	456..544	CDD:280839	35/87 (40%)
		VGCC_alpha2	590..>647	CDD:285647	21/56 (38%)
Cacna2d4	XP_036022112.1	VWA_N	155..271	CDD:400621	42/121 (35%)
		vWA_VGCC_like	284..467	CDD:238740	77/182 (42%)
		HK_sensor	<491..544	CDD:365792	18/55 (33%)
		HK_sensor	546..659	CDD:365792	48/128 (38%)
		VGCC_alpha2	694..1110	CDD:400667	136/576 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5222
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H26544
Inparanoid	1	1.050	577	1.000	Inparanoid score	I1031
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000496
OrthoInspector	1	1.000	-	-		mtm8846
orthoMCL	1	0.900	-	-		OOG6_103783
Panther	1	1.100	-	-	LDO	PTHR10166
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X365
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.960