Protein Alignment stol and Cacna2d3

DIOPT Version :10

• Sequence 1: NP_001188817.2
• Gene: stol / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: XP_063131356.1
• Gene: Cacna2d3 / 306243
• RGDID: 631361
• Length: 1091
• Species: Rattus norvegicus
• Alignment Length: 1289
• Identity: 373/1289 - (28%)
• Similarity: 598/1289 - (46%)
• Gaps: 271/1289 - (21%)

  Fly    23 IFVAFAD---QDEDIPHNEVRNWALKFGVDLWEFGRQFTKMNEIKSRFK--DNDIEVKRKDGIIL 82
            ::.|..|   .::.||.:.|:.||..||.::.....:::....::.::|  :.|:.::..||:.|
  Rat    23 LYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEIDGLQL 87

  Fly    83 LRELAAEVKNFMDFKRNAVMRLMDSAEQAALS-ELEGQGQAESPMGGQQHYDARRINEYNADGKL 146
            :::||..::.....|..||.||:::||:|.|. |.:...|.|       :::|..|||.:.||..
  Rat    88 VKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYE-------YFNAVLINERDKDGNF 145

  Fly   147 ADGARHMDIRFMRRFERLPVNLSLSSILVPHGVDLDEPDVKSALQWSGHLDPLFQNNLEQDPALS 211
            .:..:...:.....|..||||:|||.:.||..:...:|.:.:.:.||..|:.:|.:|.::||:|.
  Rat   146 LELGKEFILAPNDHFNNLPVNISLSDVQVPTNMYNKDPAIVNGVYWSESLNKVFVDNFDRDPSLI 210

  Fly   212 WQYFGSSTGFLRRFPGTAWPPEGSKGSKLIHDFRTHNWFVQAASSPKDIMILLDASSSMTEKSFD 276
            ||||||:.||.|::||..|.|:  :...:..|.|...|::|||:||||::||:|.|.||......
  Rat   211 WQYFGSAKGFFRQYPGIKWEPD--ENGVIAFDCRNRKWYIQAATSPKDVVILVDVSGSMKGLRLT 273

  Fly   277 LGMATAFNILDTLGEDDFVNLITFSEVVKTPVPCFKDRMVRATPDNIQEI-----KSAVKAIKLQ 336
            :...|..:||||||:|||.|:||::|.:....||....:|:|...|.:..     |...|.|.:.
  Rat   274 IAKQTVSSILDTLGDDDFFNIITYNEELHYVEPCLNGTLVQADRTNKEHFREHLDKLFAKGIGML 338

  Fly   337 DTANFTAGLEYAFSLLHKYNQSGAGSQCNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLIG 401
            |.|     |..||::|..:|.:|.||.|:|||||||:...:::..:..:||||...|||||||||
  Rat   339 DIA-----LNEAFNVLSDFNHTGQGSICSQAIMLITDGAVDTYDTIFAKYNWPERKVRIFTYLIG 398

  Fly   402 SDSGSRSNLHDMACSNKGFFVQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVFVAGKSG 466
            .::....||..|||:|||||.||:...:.:..|::|..|::||.::.| :|.|.|:..::
  Rat   399 REAAFADNLKWMACANKGFFTQISTLADVQENVMEYLHVLSRPKVIDQ-EHDVVWTEAYI----- 457

  Fly   467 GLGRDSEYQRR----------LVTTVSTPVFDRRNHSVRVANLLGVVGTDVPIEEIRKVIPQHKL 521
                ||...:.          |:|||:.|||.::|.:.....||||||||||::|:.|.||::||
  Rat   458 ----DSTLPQAQKLADDQGLVLMTTVAMPVFSKQNETRSKGILLGVVGTDVPVKELLKTIPKYKL 518

  Fly   522 GPNGYSFIVDNNGRVLYHPDLRPLGDANQYIDQLKPKYASVDITELELPETEFGNNNEPIEINKN 586
            |.:||:|.:.|||.:|.||:||||.:..:  .:.||.|:|||::|:|..:.:
  Rat   519 GIHGYAFAITNNGYILTHPELRPLYEEGK--KRRKPNYSSVDLSEVEWEDRD------------- 568

  Fly   587 LLNEMRGDMIKPKEGETEFTVMNHYDDSKRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVS 651
              :.:|..|:..|.|:....|....|..|||...|:.|:|..|:..||:|.:.|...:|.:.|
  Rat   569 --DVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTDIKGAPFSLGVALSRGHGKYFF-- 629

  Fly   652 QQEIRHSRNNVTEYFKGDNWRVHPD------WVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSP 710
                   |.||| ..:|.:...|||      |.||.    :||
  Rat   630 -------RGNVT-IEEGLHDLEHPDVSLADEWSYCN----TDL---------------------- 660

  Fly   711 EEQVLHFLSRAGRPGWKWMSVRPKSPQPHHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYF- 774
                                      .|.|.              |...........:..||..
  Rat   661 --------------------------HPEHR--------------HLSQLEAIKLYLKGKEPLLQ 685

  Fly   775 CDRALLQSLVRDAMVTDGLDRNTTGSSSGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLL 839
            ||:.|:|.::.||:|:..::...|.              :|:.|.:...| .|..:|:.||:||.
  Rat   686 CDKELIQEVLFDAVVSAPIEAYWTS--------------LALNKSENSDK-GVEVAFLGTRTGLS 735

  Fly   840 RWIDHVKRPEDTPEPHFSEDNVRAMDTS----------WYKRAIDQHSVEPDSFVYSVPFGSGYA 894
            |....|...:.|     ::|.::|.|..          ||:||.:|   .|.|||||:||.:|..
  Rat   736 RINLFVGAEQLT-----NQDFLKARDKENIFNADHFPLWYRRAAEQ---IPGSFVYSIPFSTGTV 792

  Fly   895 IKSNATLVTASHAIFVEHRGHKAAAGVVGLQFQHDSLAKHFINITSACTGMTG-CKRTCASDNLD 958
            .|||  :||||.:|.:...........||:|.:.:...:.|...:..|..:.| |..:|..:.::
  Rat   793 NKSN--VVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQCASLDGKCSISCDDETVN 855

  Fly   959 CYVLDNSGFVIISEEMEHTGKFFGQIDGTIMDSLVQDRIYKRVTVNDYQGVCSDADNPYTAAGGI 1023
            ||::||:||:::||:...||.|||:::|.:|:.|:....:||:|:.|||.:|........:|.|:
  Rat   856 CYLIDNNGFILVSEDYTQTGDFFGEVEGAVMNKLLTMGSFKRITLYDYQAMCRANKESSDSAHGL 920

  Fly  1024 LKPNR----LGSWFFNHLLALSAAWLSLMPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNEN 1084
            |.|.:    ...|....|:      |.|:..:|.:|...:.|
  Rat   921 LDPYKAFLSAAKWIVTELV------LFLVEFNLCSWWHSDMT----------------------- 956

  Fly  1085 EYNMQVDQEMDEFFTTADVEYTTPPPRQHKPHVGPRFSPDPHNARRCDLRTDLYMLQPERLNQGG 1149
                ...|::.:.....|.||             |.|..:         ||
  Rat   957 ----AKAQKLKQTLEPCDTEY-------------PAFVSE---------RT-------------- 981

  Fly  1150 QNNPLKGKLTNCHVSGCERPFSVQKIPHSNLILLVVDTLCPCGSKQLDIEPLEEAGV---IGACS 1211
                :|....|.....|.:.|.:|:||.|||.::|||:.|.|.|    :.|:..|.:   .....
  Rat   982 ----IKETTGNIACEDCSKSFVIQQIPSSNLFMVVVDSSCLCES----VAPITMAPIEIRYNESL 1038

  Fly  1212 TRRQGQEQESRRRPKKCINYHPEEIEIQQCGRGSTLLHMSGSVIVAHLLMVTVT 1265
            ...:.:.|:.||||:.|..:|||| ..::||..|:|     ...||.||:..|:
  Rat  1039 KCERLKAQKIRRRPESCHGFHPEE-NARECGGASSL-----QAQVALLLLPLVS 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stol	NP_001188817.2	VWA_N	130..230	CDD:462464	36/99 (36%)
		vWA_VGCC_like	245..428	CDD:238740	80/187 (43%)
		PDC2_MCP_like	511..643	CDD:350337	45/131 (34%)
		VGCC_alpha2	810..>1048	CDD:462488	75/252 (30%)
Cacna2d3	XP_063131356.1	None