Protein Alignment stol and Cachd1

DIOPT Version :10

• Sequence 1: NP_001188817.2
• Gene: stol / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: NP_001178687.1
• Gene: Cachd1 / 298267
• RGDID: 1310770
• Length: 1288
• Species: Rattus norvegicus
• Alignment Length: 1161
• Identity: 226/1161 - (19%)
• Similarity: 382/1161 - (32%)
• Gaps: 411/1161 - (35%)

  Fly   196 LDPLFQNNLEQDPALSWQYFGSSTGFLRRFPGTAWPPEGSKGSKLIHDFRTHNWFVQAA-SSPKD 259
            |:.:..:||:.:|.:.||||.|..|....||...:..:||      ::.|:...:|... ...|.
  Rat   184 LNSVLADNLKSNPGIKWQYFSSEEGIFTVFPAHKFRCKGS------YEHRSRPIYVSTVRPQSKH 242

  Fly   260 IMILLDASSSMTEKSFDLGMATAFNILDTLGEDDFVNLITFSEVVKTPV--PCFKDRMVRATPDN 322
            |:::||..:|:|:....:....|..||..:.|.|.::::|.::.|:|..  .|:|..:..||.:.
  Rat   243 IVVILDHGASVTDTQLQIAKDAAQVILSAIDEHDKISVLTVADTVRTCSLDQCYKTYLSPATSET 307

  Fly   323 IQEIKSAVKAIKLQDT-ANFTAGLEYAFSLLHKYNQSGAGSQCNQAIMLITESTSESHKD----- 381
            .:::.:.|.::|..|: .....|...||.|: :...:....|.|..:::|..|...:.||
  Rat   308 KRKMSTFVSSVKPSDSPTQHAVGFHRAFQLI-RSTSNNTRFQANTDMVIIYLSAGITSKDSSEED 371

  Fly   382 ------VIKQYN-WPHMPVRIFTYLIGSD--SGSR--SNLHDMACSN---------------KGF 420
                  ||.:.| :.:..|.|.||.:.:|  :|.:  :.|.|:|..|               ||.
  Rat   372 KKATLRVINEENGFLNNSVMILTYALMNDGVTGLKELAFLRDLAEQNSGKYGIPDRTALPVIKGS 436

  Fly   421 FVQINDYDEARRKVIDYALVMARPMIMYQADHPVHWSPVFVAGKSGGLGRDSEYQRRLVTTVSTP 485
            .:.:|........|..:...:...||    |..|...|.           ..|....|:.|||.|
  Rat   437 MMVLNQLSNLETTVGRFYTNLPNRMI----DEAVFSLPF-----------SDEMGDGLIMTVSKP 486

  Fly   486 VFDRRNHSVRVAN-LLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDL-RP--LG 546
            .:        ..| |||:||.||.:..|.:.:..::.....|:|::|:.|..|.||.| ||  |.
  Rat   487 CY--------FGNLLLGIVGVDVNLAYILEDVTYYQDSLASYTFLIDDKGYTLMHPSLTRPYLLS 543

  Fly   547 DANQYIDQLK----PKYASVDITELELPETEFGNNNEPIEINKNL---LNEMRGDMIKPKEGETE 604
            :...:.|.:.    ||:..|....|.||   .|:....:.:|.:|   :|::|      :.|:..
  Rat   544 EPPLHTDIIHYENIPKFELVRQNILSLP---LGSQIITVPVNSSLSWHINKLR------ETGKEA 599

  Fly   605 FTVMNHYDDSKRVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVSQQEI--RHSRNNVTEYFK 667
            :.|               .|.:..::||.|.|.||          |.|.||  :..:|
  Rat   600 YNV---------------SYAWKMVQDTSFILCIV----------VIQPEIPVKQLKN------- 632

  Fly   668 GDNWRVHPDWVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVL-HFLSRAGRPG----WK 727
                          .|:|                        |..::| |.|...|:|.    :|
  Rat   633 --------------LNTV------------------------PSSKLLYHRLDLLGQPSACLHFK 659

  Fly   728 WMSVRPKSPQPHHNMHSGSNGGNAPGSSHFGS--QHQSS-QGSRKAEPYFCDRALLQSLVRDAMV 789
            .::.   ...|...:.:||          |.|  :|.|. :..|..|.|   .|.|....| .:.
  Rat   660 QLAT---LESPTVMLSAGS----------FSSPYEHLSQPETKRMVEHY---TAYLSDNTR-LIA 707

  Fly   790 TDGLD---RNTTGSSSGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLRWIDHVKRPEDT 851
            ..||.   ||...::|     |.....|..::......::| ..::||.:|:||..     |...
  Rat   708 NPGLKFSVRNEVMATS-----HVTDEWMTQMEMSSLNTYIV-RRYIATPNGVLRIY-----PGSL 761

  Fly   852 PEPHFSEDNVRAMDTSWYKRAIDQHSVEPDSFVYSVPF----GSGYAIKSNATLVTASHAIFVE- 911
            .:..|  |..|   ..||..|:    ..|.....:.|:    |:||       :||.||.|...
  Rat   762 MDKAF--DPTR---RQWYLHAV----ANPGLISLTGPYLDVGGAGY-------VVTISHTIHSSS 810

  Fly   912 ---HRGHKAAAGVVGLQFQHDSLAKHFINITSACTGMTGCKRTCASDNLDCYVLDNSGFVIISEE 973
               ..||..|  |:|:.|......|..:::...|....|.|       :.|:::::.|:::
  Rat   811 TQLSSGHTVA--VMGIDFTLRYFYKVLMDLLPVCNQDGGNK-------IRCFIMEDRGYLV---- 862

  Fly   974 MEHTGKFFGQIDGTIMDSLVQDRIYKRVTVNDYQGVCSDADNPYTAAGGILKPNRLGSWFFNHLL 1038
                                                                             
  Rat   863 ----------------------------------------------------------------- 862

  Fly  1039 ALSAAWLSLMPASLRAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADV 1103
                           |.|                                          |..|.
  Rat   863 ---------------AHP------------------------------------------TLVDP 870

  Fly  1104 EYTTPPPRQHKPHVGPRFSPD----PHNARR--CDLRTDLYMLQPERLNQGGQNNPLKGKLTN-C 1161
            :...|..:||..|..|..:.|    |:..::  |:..:|..:.:..:.     |..|.|.||| .
  Rat   871 KGHAPLEQQHITHKEPLVANDILNHPNFVKKNLCNSFSDRTVQRSYKF-----NTSLVGDLTNLV 930

  Fly  1162 HVSGCERPFSVQKIPHSNLILLVV----DTLCPCGSKQLDIEPLEEAGVIGACSTRRQGQEQESR 1222
            |.|.|.: :.:.:||.:|..:.:|    |:|..|....:|
  Rat   931 HGSHCSK-YRLTRIPGTNAFVGIVNETCDSLAFCACSMVD------------------------- 969

  Fly  1223 RRPKKCINYHPEE-----------IEIQQCGRGSTLLHMSGSVIVAHLLMVTVTFV 1267
               :.|:|.|..|           :|:.:|....|...........|...||.|.:
  Rat   970 ---RLCLNCHRMEQNECECPCECPLEVNECTGNLTNAENRNPSCEVHQEPVTYTAI 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stol	NP_001188817.2	VWA_N	130..230	CDD:462464	12/33 (36%)
		vWA_VGCC_like	245..428	CDD:238740	49/217 (23%)
		PDC2_MCP_like	511..643	CDD:350337	33/141 (23%)
		VGCC_alpha2	810..>1048	CDD:462488	36/245 (15%)
Cachd1	NP_001178687.1	VWA_N	103..218	CDD:462464	12/33 (36%)
		vWFA	227..422	CDD:469594	46/195 (24%)
		HK_sensor	<463..503	CDD:365792	17/58 (29%)
		dCache_1	688..882	CDD:460673	55/359 (15%)