Protein Alignment stol and unc-36

DIOPT Version :10

• Sequence 1: NP_001188817.2
• Gene: stol / 34921
• FlyBaseID: FBgn0028863
• Length: 1271
• Species: Drosophila melanogaster
• Sequence 2: NP_001040851.1
• Gene: unc-36 / 176155
• WormBaseID: WBGene00006772
• Length: 1249
• Species: Caenorhabditis elegans
• Alignment Length: 1332
• Identity: 273/1332 - (20%)
• Similarity: 478/1332 - (35%)
• Gaps: 423/1332 - (31%)

  Fly   126 MGGQQHYDARRINEYNADGK--LADGARHMDIRFMRRFERLPVNLSLSSILVPHGVDLDEPDVKS 188
            |..:|..|...|.|.|..||  ..:..:..::.....|..||.:...|::.:|..:.....|:..
 Worm   116 MSAKQGNDGTTIYESNHLGKRLKVNETKSFNLTQNANFYTLPTSSVSSAVHIPTPLYDRNEDLLR 180

  Fly   189 ALQWSGHLDPLFQNNLEQDPALSWQYFGSSTGFLRRFPGTAWPPEGSKGSKLIHDFRTHNWFVQA 253
            .:.|| .:|.:::.|.|:...|::|.|.|..|::|.:|..:|..:.......:.|.|...|::.:
 Worm   181 KIDWS-DIDAVYRTNREETKDLAFQLFCSEAGYMRYYPAASWFWDNQDEHLDLFDCRNTEWYINS 244

  Fly   254 ASSPKDIMILLDASSSMTEKSFDLGMATAFNILDTLGEDDFVNLITFSEVVKTPVPC-FKDRMVR 317
            |::.|:::|:||.|.||..:.:::...|...||:||..:|:.|::|||:.......| ..:.:::
 Worm   245 ATNSKNVLIMLDMSGSMLGQRYEVAKQTTEAILETLSHNDYFNIMTFSKNTFLLDGCNGTNGLLQ 309

  Fly   318 ATPDNIQEIKSAVKAIKLQDTANFTAGLEYAFSLL-----------------------HKYN--- 356
            ||..|.:.::..:...:.:..|.:...|..|||:|                       ::|.
 Worm   310 ATMRNKKALRRKMDTYQSEGKAEYEKALPLAFSVLLDLKGSYALYTKEEMSMMSANATNEYQFHL 374

  Fly   357 -----------------QSGAGSQ----CNQAIMLITESTSESHKDVIKQYNWPHMPVRIFTYLI 400
                             .:|.|..    |...|||||:....::|.:...|| ....||:||:|:
 Worm   375 ELPEHVLAATKQYIDSINNGGGDNNRGACENVIMLITDGAPNAYKKIFDMYN-ADKKVRVFTFLV 438

  Fly   401 GSDSGSRSNLHDMACSNKGFFVQINDYDEARRKVIDYALVMARPM-IMYQADHPVHW-------- 456
            |.::...:.:.:|||:|:|:.|.:.:..:...|:..|...|:|.: ..|:....:.|
 Worm   439 GDEAIDFNEVREMACNNRGYMVHVANMADVDEKIHHYIRRMSRVVGRHYKESGQLSWWTGVYRER 503

  Fly   457 ----------SPVFVAGKSGG------------LGRDSEYQRRLVTTVSTPVFDRRNHSVRVAN- 498
                      .||.:..:|..            |.:.....|..|||||.||         :.|
 Worm   504 LYLPRPEIFAEPVPITNQSFAVMNKMASRRKIRLQKSEARSRMFVTTVSYPV---------IVNE 559

  Fly   499 -LLGVVGTDVPIEEIRKVIPQHKLGPNGYSFIVDNNGRVLYHPDLRPLGDANQYIDQLKPKYASV 562
             .:||...::|:.|:.:......:|...|.|::|.||.|:.||.|||:....:|   .|..|.::
 Worm   560 TFMGVAAVNIPLTEVAQKSHPANIGSKSYFFMLDQNGFVMTHPQLRPIDPFTKY---HKQNYNNM 621

  Fly   563 DITELELPETEFGNNNEPIEINKNLLNEMRGDMIKPKEGETEFTVMNHYDDSK------------ 615
            |:.|||:.:            |:|:.:..:...:.....|:........||.:
 Worm   622 DLLELEVGQ------------NQNVRSSQKSQAVSDLVCESGANYAECVDDLRKAVRKMIIDCDN 674

  Fly   616 ----------------RVSTRTHRYFYGPIEDTPFTLAIVLPEKYGSHEFVSQQEIRHSRNNVTE 664
                            ||..:|:.|:...|....|.|.:.:.:  |....|.:::.::....|..
 Worm   675 SDVQQLDVLYATELLDRVYPQTNTYYAECINHANFVLGLAVAK--GDDYRVVKKQKKYDFGRVKM 737

  Fly   665 YFKGD-NWRVHPDWVYCEYNSVSDLEKERESSGEYSSRDQEPSFGSPEEQVLHFLSRAGRPGWKW 728
            .:.|| .||:||.|.||..|. :|....:|.:.|..::..
 Worm   738 DWMGDKRWRLHPHWRYCFLND-TDTHMSKEEAFEIYAQQM------------------------- 776

  Fly   729 MSVRPKSPQPHHNMHSGSNGGNAPGSSHFGSQHQSSQGSRKAEPYFCD--RALLQSLVRDAMVTD 791
                             |:.|.|                    |..|:  |.|::.|:.|...|.
 Worm   777 -----------------SDSGKA--------------------PLLCEYRRNLVEKLLLDMEATS 804

  Fly   792 GL-DRNTTGSSSGKEDKHPIATLMAILKRQGYQKFVVATSFVATRSGLLRW-------------- 841
            .| |...|..:..|.:                   ::..:|.||.||::|:
 Worm   805 NLIDSWDTQFNFMKNN-------------------LIHLAFFATPSGMIRYYNLTLQDYDYIDPY 850

  Fly   842 ------IDHVKRPEDTPEP--HFSED-NVRAMDTSWYKRAIDQHSVEPDSFVYSVPFGS------ 891
                  |.|:...|...|.  ||..| |.::.|..:|:||:..    .|:.::.|...|
 Worm   851 WSIFEHIGHLLSIEHAQESYNHFITDLNRKSTDDRYYRRAVRM----KDTIMFDVSNNSKIWYKS 911

  Fly   892 -----GYAIKSNATLV-TASHAIFVEHRGHKAAAGVVGLQFQH----DSLAKHFINITSACTGMT 946
                 ||.:..|.|:: .|..||:::    ||..||.|.:|.:    |::|:|
 Worm   912 ETQLTGYGLNENLTMLGQAFKAIYLD----KAVLGVSGFEFAYDHVVDTMAEH------------ 960

  Fly   947 GCKRTCASDNLD-CYVLDNSGFVIISEEME------------HTGKFFG---QIDGTIMDSLVQD 995
            ||.   |||:.. |.:||...:|..|.:.:            |..::||   :|....|..||::
 Worm   961 GCP---ASDDRKWCVLLDEHAYVFFSNQNDISYEDYLVGKGKHISQYFGGLNRIAQRAMALLVEN 1022

  Fly   996 RIYKRVTVNDYQGVCSDADNPYTAAGGILKP----NRLGSWFFNHLLAL----SAAWLSLMPASL 1052
            :.|.::|..|.|.||. |:...|.:|..|:|    .|.....||.::.|    |..:|..:|
 Worm  1023 KFYTKLTYTDNQAVCK-AEKVVTTSGNRLRPFYPIFRFLMQTFNFMVRLASQISGGFLIWLP--- 1083

  Fly  1053 RAWPQEEYTYDNEDVVFVDNNYSDEYEFGNENEYNMQVDQEMDEFFTTADVEYTTPPPRQHKPHV 1117
                                              |:|        ||.|   ||.      ..|.
 Worm  1084 ----------------------------------NIQ--------FTEA---YTA------SFHE 1097

  Fly  1118 GPRFSPDPHNARRCDLRTDLYMLQPERLNQGGQNNPLKGKLTN-------CHVSG-CERPFSVQK 1174
            |....|       |..::..|.     .|:.|:|.|....|.|       |.::. |........
 Worm  1098 GTDVYP-------CPKQSSFYF-----SNKDGKNRPGTTHLVNGNRSERPCKMNAKCSVKMEASF 1150

  Fly  1175 IPHSNLILLVV-----------DTLC--------PCGSKQLDIEPLEEAGVIGACSTRRQGQEQE 1220
            :..:||:::.:           ::.|        |.|.:::..|.        .|      :|.|
 Worm  1151 VDGTNLVMVWITQDKASENCYDESECSMEISNQVPFGFEEVKNEE--------TC------EENE 1201

  Fly  1221 SRRRPKKCINY----HPEEIEIQQCGRGSTLL 1248
            .|:.....:.|    ...|.|.:.|....|::
 Worm  1202 KRKSKANDVCYSIDDDDSENERRPCSTSPTIV 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
stol	NP_001188817.2	VWA_N	130..230	CDD:462464	25/101 (25%)
		vWA_VGCC_like	245..428	CDD:238740	54/230 (23%)
		PDC2_MCP_like	511..643	CDD:350337	32/159 (20%)
		VGCC_alpha2	810..>1048	CDD:462488	71/300 (24%)
unc-36	NP_001040851.1	VWA_N	95..221	CDD:462464	26/105 (25%)
		vWA_VGCC_like	236..466	CDD:238740	54/230 (23%)
		VGCC_alpha2	791..>1055	CDD:462488	73/306 (24%)